| Title | Serum butyrycholinesterase activity as a marker of aging process in drug metabolism: study in Greek aging population | ||
| Authors | M. Mironidou-Tzouveleki, Ch. Dokos and Κ. Kalousis
A’ Laboratory of Pharmacology, Medical School, Aristotelian University, Thessaloniki, Greece |
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| Citation | Mironidou-Tzouveleki, M., Dokos, C., Kalousis, K.: Serum butyrycholinesterase activity as a marker of aging process in drug metabolism: study in Greek aging population, Epitheorese Klin. Farmakol. Farmakokinet. 22(2): 250-253 (2008) | ||
| Publication Date | 23-25 May 2008 | ||
| Full Text Language | English | ||
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
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| Keywords | Butyrylcholinesterase, drug metabolism, aging. | ||
| Other Terms | Review article | ||
| Summary | Elder people receive a significant number of drugs for therapeutic purposes. Surprisingly the percentage of this aging population in clinical trials of drug evaluation is small in proportion to the amount of drugs administrated. Serum cholinesterases, like butyrylcholinesterase, are metabolic enzymes of Phase I reactions, important for oxidation of xenobiotic compounds. Purpose of this study is to investigate the possible alterations of serum butyrylcholinesterase actvity for each decade of life in healthy humans aged 40 to 80 years in Greece. Blood samples were collected from 80 clinically healthy persons who were divided into equal groups by decades of age (Group 1: 40-50 years of age, Group 2: 51-60 years of age, Group 3: 61-70 years of age, Group 4: 71-80 years of age) and sex. Serum plasma was extracted from each specimen and used as material for spectrophotometric estimation of plasma butyrylcholinesterase activity, according to the modified colorimetric method by Knedel and Böttger. Mean ratio decreases from Group 1 to 2, Group 2 to 3, Group 3 to 4 by 0.086%, 5.163%, 24.13% respectively. The mean of butyrylcholinesterase activity of this study is 4757.725 ±1198.145 which is in the physiological range of values. This decline is more impressive between Group 3 and 4. Pearson’s correlation test showed a statistically significant age dependent fall of plasma butyrylcholinesterase activity. This is clinically valuable for administration of agents affecting the cholinergic system. Drug metabolism in aging Greek population seems to decline according to aging plasma cholinesterases activities, like butyrylcholinesterase. Recent studies indicate that butyrylcholinesterase is not just a marker of cholinergic system activity for drug administration safety but also for cellular aging. There-fore butyrylcholinesterase activity may be used as a biomarker of aging process in drug metabolism | ||
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Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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