| Title | The α2B and β3 adrenergic receptor genes polymorphisms in women with polycystic ovarian syndrome (PCOS) and their association with insulin resistance and basal metabolic rate (BMR) | |
| Authors | Sosanna Kritikou³, Alexandros D. Saltamavros¹,², George Adonakis¹, Vicky Koika¹, Kleanthis Koufogiannis¹, Kostas Spyropoulos², George Kourounis¹, Venetsana Kyriazopoulou², Neoklis A. Georgopoulos¹ and Christodoulos Flordellis³
Departments of 1. Obstetrics and Gynecology, Division of Reproductive Endocrinology (ADS, VK, MK, GA, KP, GK, NAG),University Hospital 2. Internal Medicine, Divisions of Endocrinology (ADS, VK) and Pulmonology (KS),University Hospital 3. Pharmacology (SK, CF), Medical School, University of Patras, 26500 Patras, Greece |
|
| Citation | Kritikou, S., Saltamavros, A., Adonakis, G., Koika, V., Koufogiannis, K. et al: The α2B and β3 Adrenergic Receptor Genes Polymorphisms in Women with Polycystic Ovarian syndrome (PCOS) and their association with insulin resistance and basal metabolic rate (BMR), Epitheorese Klin. Farmakol. Farmakokinet. 20(2): 238-240 (2006) | |
| Publication Date | Accepted for publication: 19-20 May 2006 | |
| Full Text Language | English | |
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
pharmakonpress[at]pharmakonpress[.]gr |
|
| Keywords | α2B adrenergic receptor gene polymorphism, β3 adrenergic receptor gene polymorphism, PCOS, insulin resistance, BMR. | |
| Other Terms | review article | |
| Summary | The aim of the present study was to determine the incidence of α2B and β3 adrenergic receptors gene polymorphisms in Greek women with PCOS as well as their association with the basal metabolic rate and insulin resistance. The study included 91 Greek PCOS patients. Genotype frequencies were similar in patients and in a group of 47 normal volunteers. The patients’ BMR, adjusted for fat-free mass, fat mass, sex and age, did not differ between the α2B and β3 genotypes. Moreover, the polymorphisms were not associated with the patients’ BMI and insulin resistance. | |
| References | 1. Dunaif A., Givens J.R., Haseltine F.P., Merriam G.R.: Current issues in endocrinology and Metabolism: polycystic ovary syndrome. Pp. 377-384, Blackwell, 1992
2. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group (2004) Rotterdam 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil. Steril. 81: 19-25 (2004) 3. Ferrannini E.: The theoretical basis of indirect calorimetry: a review. Metabolism 37: 287-301 (1988) 4. Ravussin E., Lillioja S., Knowler W.C., Christin L., Freymond D., Abbott W.G., Boyce V., Howard B.V., Bogardus C.: (1988) Reduced rate of energy expenditure as a risk factor for body-weight gain. N. Engl. J. Med. 318: 467-472 (1988) 5. Rawson E.S., Nolan A., Silver K., Shuldiner A.R., Poehlman E.T.: (2002) No effect of the Trp64Arg beta(3)-adrenoceptor gene variant on weight loss, body composition, or energy expenditure in obese, caucasian postmenopausal women. Metabolism 51: 801-805 (2002) 6. Sykiotis G.P., Polyzogopoulou E., Georgopoulos N.A., Trakada G., Spyropoulos K., Kalfarentzos F., Papavassiliou A.G., Vagenakis A.G., Flordellis C.: (2003) The a2B adrenergic receptor deletion/insertion polymorphism in morbid obesity. Clin. Auton. Res. 13: 201-207 (2003) 7. Alevizaki M., Thalassinou L., Grigorakis S.I., Philippou G.,Lili K., Souvatzoglou A., Anastasiou E.: Study of the Trp64Arg polymorphism of the beta3-adrenergic receptor in Greek women with gestational diabetes. Diabetes Care 23: 1079-1083 (2000) 8. Perez-Bravo F., Echiburu B., Maliqueo M., Santos J.L., Sir- Petermann T.: Tryptophan 64àarginine polymorphism of beta- 3-adrenergic receptor in Chilean women with polycystic ovary syndrome. Clin. Endocrinol. (Oxf). 62: 126-131 (2005) 9. Witcel S.F., Smith R., Crivellaro C.E., Della Manna T., Dichtchekenian V., Setian N., Damiani D.: No association between body mass index and β3 adrenergic receptor variant (W64R) in children with premature pubarche and adolescent girls with hyperandrogenism. Fertil. Steril. 73: 509-514 (2000) 10. Heinonen P., Koulu M., Pesonen U., Karvonen M.K., Rissanen A., Laakso M., Valve R., Uusitupa M., Scheinin M.: Identification of a three-amino acid deletion in the alpha2B– adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects. J. Clin. Endocrinol. Metab. 84: 2429-2433 (1999) |
|
| Relative Papers |
Online ISSN 1011-6575
Άρθρα Δημοσιευμένα σε αυτό το Περιοδικό Καταχωρούνται στα:
- Chemical Abstracts
- Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
Συντακτικη Επιτροπή-Editorial Board
| ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 2006 – ANNUAL SUBSCRIPTION 2006 | |
| Γλώσσα Πλήρους Κειμένου – Full Text Language | Αγγλικά – English |
| Παραγγελία – Αγορά – Order – Buy | Ηλεκτρονική Μορφή: pdf (70 €) – Digital Type: pdf (70 €)
pharmakonpress[at]pharmakonpress[.]gr |
| Έντυπη Μορφή (70 € + έξοδα αποστολής) – Printed Type (70 € + shipping)
pharmakonpress[at]pharmakonpress[.]gr |
|