| Title | Study of the relationship between α2B-adrenergic receptor polymorphism and restenosis following coronary angioplasty: preliminary report | |
| Authors | Antonis S. Manolis¹, Nikolaos Patsouras², Ioannis Ilias³, John Constantakopoulos³, Anastasia Pyriohou³, Anastasios Lymperopoulos³, Dionysios Spathas⁴ and Christodoulos Flordellis³
1. First Department of Cardiology, Evagelismos General Hospital of Athens, Athens, Greece 2. Department of Cardiology, Patras University Hospital, Rion, Patras, Greece 3. Department of Pharmacology, Patras University School of Medicine, Rion, Patras, Greece 4. Department of Biology, Patras University School of Medicine, Rion, Patras, Greece |
|
| Citation | Manolis, A.S., Patsouras, N., Ilias, I., Constantakopoulos, J., Pyriohou, A. et al Study of the relationship between α2B-adrenergic receptor polymorphism and restenosis following coronary angioplasty: preliminary report, Epitheorese Klin. Farmakol. Farmakokinet. 20(2): 246-248 (2006) | |
| Publication Date | Accepted for publication: 19-20 May 2006 | |
| Full Text Language | English | |
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
pharmakonpress[at]pharmakonpress[.]gr |
|
| Keywords | α2B-adrenergic receptor, polymorphisms, restenosis, coronary heart disease. | |
| Other Terms | review article | |
| Summary | We investigated whether the polymorphism of the α2B-adrenergic receptor gene was associated with the risk of restenosis in 96 Greek coronary artery disease patients undergoing coronary angioplasty and stent implantation. The end-point of the current study was the incidence of restenosis at seven months of clinical follow-up. For the comparison of genotype frequency a control group of 83 healthy individuals was also studied. Seventy of 96 patients had the insertion/insertion genotype, 23/96 had the insertion/deletion genotype and 3/96 had the deletion/deletion genotype; the frequency distribution was not different from that of the healthy control subjects. Restenosis occurred in 15 (15.6%) of the 96 patients. In the population studied, α2B-adrenoreceptor polymorphisms were not found to predispose patients to an increased incidence of restenosis. This finding should be considered as preliminary, taking into account the small number of studied patients and the rarity of the deletion/deletion genotype. | |
| References | 1. Richman J.G., Regan J.W.: Alpha 2-adrenergic receptors increase cell migration and decrease F-actin labeling in rat aortic smooth muscle cells. Am. J. Physiol. 274: 654-662 (1998)
2. Faber J.E., Yang N., Xin X.: Expression of alpha-adrenoreceptor subtypes by smooth muscle cells and fibroblasts in rat aorta and in cell culture. J. Pharmacol. Exp. Ther. 298: 441- 452 (2001) 3. Altman J.D., Trendelenburg A.U., MacMillan L., Bernstein D., Limbird L., Starke K., et al.: Abnormal regulation of the sympathetic nervous system in alpha2A-adrenergic receptor knockout mice. Mol. Pharmacol. 56: 154-161 (1999) 4. Sallinen J., Link R.E., Haapalinna A., Viitamaa T., Kulatunga M., Sjoholm B., et al.: Genetic alteration of alpha 2C-adrenoreceptor expression in mice: influence on locomotor, hypothermic and neurochemical effects of dexmedetomidine, a sub-type-nonselective alpha 2-adrenoreceptor agonist. Mol. Pharmacol. 51: 36-46 (1997) 5. Sallinen J., Haapalinna A., MacDonald E., Viitamaa T., Lahdesmaki J., Rybnikova E., et al.: Genetic alteration of the alpha2-adrenoreceptor subtype c in mice affects the development of behavioural despair and stress-induced increases in plasma corticosterone levels. Mol. Psychiatry 4: 443-452 (1999) 6. Heinonen P., Koulu M., Pesonen U., Karvonen M.K.,Rissanen A., Laakso M., et al.: Identification of three-amino acid deletion in the alpha 2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects. J. Clin. Endocrinol. Metab. 84: 2429-2433 (1999) 7. Small K.M., Brown K.M., Forbes S.L., Liggett S.B.: Polymorphic deletion of three intracellular acidic residues of the alpha2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization. J. Biol. Chem. 276. 4917-4922 (2001) 8. Zee R.Y., Hoh J., Cheng S., Reynolds R., Grow M.A., Silbergleit A., et al.: Multi-locus interactions predict risk for post- PTCA restenosis: an approach to the genetic analysis of common disease. Pharmacogenomics J. 2: 197-201 (2002) |
|
| Relative Papers |
Online ISSN 1011-6575
Άρθρα Δημοσιευμένα σε αυτό το Περιοδικό Καταχωρούνται στα:
- Chemical Abstracts
- Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
Συντακτικη Επιτροπή-Editorial Board
| ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 2006 – ANNUAL SUBSCRIPTION 2006 | |
| Γλώσσα Πλήρους Κειμένου – Full Text Language | Αγγλικά – English |
| Παραγγελία – Αγορά – Order – Buy | Ηλεκτρονική Μορφή: pdf (70 €) – Digital Type: pdf (70 €)
pharmakonpress[at]pharmakonpress[.]gr |
| Έντυπη Μορφή (70 € + έξοδα αποστολής) – Printed Type (70 € + shipping)
pharmakonpress[at]pharmakonpress[.]gr |
|