Τόμος 22 (2008) – Τεύχος 2 – Άρθρο 87 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 22 (2008) – Issue 2 – Article 87 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Title Effects of pesticides on exposed populations from four European countries
Authors S.M. Piperakis1, K. Kontogianni1, G. Karanastasi1, C. Siffel2, A. Cebulska-Wasilewska3, R. Markos4, Z. Iakovidou-Kritsiand M.M. Piperakis1

1. Biology Unit, Department of Pre-School Education, University of Thessaly, Volos, Greece

2. Department of Human Genetics and Teratology, B. Johan National Center for Epidemiology, Budapest, Hungary

3. Department of Radiation and Environmental Biology, Niewodniczanski Institute of Nuclear Physics, Krakow, Poland

4. Grup de Mutagenesi, Departament de Genetica i de Microbiologia, Facultat de Ciencies, Universitat Autonoma de Barcelona, 08193 Bellaterra, Spain   

5. Laboratory of Biology and Genetics, Medical School, Aristotle University, Thessaloniki, Greece

Citation Piperakis, S.M., Kontogianni, K., Karanastasi, G., Siffel, C., Cebulska-Wasilewska. A. et al.: Effects of pesticides on exposed populations from four European countries, Epitheorese Klin. Farmakol. Farmakokinet. 22(2): 291-293 (2008)
Publication Date 23-25 May 2008
Full Text Language English
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Keywords Comet assay, DNA damage, DNA repair, greenhouses, pesticides.
Other Terms Review article
Summary The potential genetic hazard of pesticides to humans is of great concern, in particular in occupational and environmental settings because of their widespread use for domestic and industrial applications. In the present study the genotoxic potentials of commonly applied pesticides have been evaluated using the single cell gel electrophoresis (comet assay). This method was used to quantify the level of DNA damage in lymphocytes of farmers who were occupationally exposed to pesticides. Particularly, we measured the amount of DNA damage in isolated human peripheral lymphocytes from agricultural workers from Spain, Hungary, Poland and Greece in comparison to healthy men from the same areas who had no previous occupational exposure to pesticides. All results indicated no statistically significant differences in basal DNA damage between our study groups. In addition, exposure of peripheral blood lymphocytes to hydrogen peroxide or γ-irradiation led to a similar degree of additional DNA damage and subsequent repair for all our studied populations. In conclusion the greenhouse workers who participated in this study had no detectable increased DNA damage or alteration in their cellular response to DNA damage from our control populations.
References 1. IARC: International Agency for Research on Cancer, Occupational Exposures in Intesticide Application, and Some Pesticides. Vol. 53: IARC Monographs, Lyon, France, 1991

2. Barthel E.: Increased risk of lung cancer in pesticide-exposed male agricultural workers. J. Toxicol. Enviror. Health 8: 1027-1040 (1981)

3. Viel J.F., Chalier B.: Bladder cancer among French farmers: does exposure to pesticides in vineyards play a part? Occup. Environ. Med. 52: 587-592 (1995)

4. Blair A., Zahm S.H.: Agricultural exposures and cancer. Environ. Health Perspect. 103(S8): 205-208 (1995)

5. Garaj-Vrhovac V., Zeljezic D.: Evaluation of DNA dam-age in workers occupationally exposed to pesticides using single-cell gel electrophoresis (SCGE) assay. Pesticide genotoxicity revealed by comet assay. Mutat. Res. 469: 279-285 (2000)

6. Piperakis S.M., Petrakou E., Tsilimigaki S., Sagnou M., Monogiudis E., Haniotakis G., Karkaseli H., Sarikaki E.: 2003. Biomonitoring with the comet assay of Greek greenhouse workers exposed to pesticides. Environ. Mol. Mutagen 41: 104-110 (2003)

7. Visvardis E.-E., Tassiou A.M., Piperakis S.M.: Study of DNA damage induction and repair capacity of fresh and cryopreserved lymphocytes exposed to H2O2 and γ-irradiation with the alkaline comet assay. Mutat. Res. 383: 71-80 (11997)

8. Tsilimigaki S., Messini-Nikolaki N., Kanariou M., Piperakis S.M.: A study on the effects of seasonal solar radiation on exposed populations. Mutagenesis 18: 139-143 (2003)

9. Bolognesi C., Parrini M., Bonassi S., Ianello G., Salanitto A.: 1993. Cytogenetic analysis of a human population occupationally exposed to pesticides. Mutat. Res. 285: 239-249 (1993)

10. Bolognesi C., Landini E., Perrone E., Roggieri P.: Cytogenetic biomonitoring of a floriculturist population in Italy: micronucleus analysis by fluorescence in situ hybridization (FISH) with an all-chromosome centromeric probe. Mutat. Res. 557: 109-117 (2004)

11. Lucero L., Pastor S., Suárez S., Durbán R., Gómez C., Parrón T., Creus A., Marcos R.: Cytogenetic biomonitoring of Spanish greenhouse workers exposed to pesticides: micronuclei analysis in peripheral blood lymphocytes and buccal epithelial cells. Mutat. Res. 464: 255–262 (2000)

12. Pastor S., Creus A., Parron T., Cebulska-Wasilewska A., Siffel C., Piperakis S., Marcos R.: Biomonitoring of four European populations occupationally exposed to pesticides: use of micronuclei as biomarkers. Mutagenesis 18: 249-258 (2003)

13. Garaj-Vrhovac V., Zeljezic D.: Cytogenetic monitoring of Croatian population occupationally exposed to a complex mixture of pesticides. Toxicology 165: 153-162 (2001)

14. Piperakis S.M., Petrakou E., Tsilimigaki S., Sagnou M., Monogiudis E., Haniotakis G., Karkaseli H., Sarikaki E.: Biomonitoring with the comet assay of Greek greenhouse workers exposed to pesticides, Environ. Mol. Mutagen 41: 104-110 (2003)

15. Scarpato R., Migliore L., Angotai G., Fedi A., Migli L., Loprieno N.: Cytogenetic monitoring of a group of Italian floriculturists, no evidence of DNA damage related to pesticide exposure. Mutat. Res. 367: 73-82 (1996)

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