| Title | Effect of somatostatinergic analogues on the ischemia-induced release of [3H]-D-Aspartate and [3H]-GABA from rat retina and hippocampus | ||
| Authors | V. Sourlas, V. Athanasiou and A. Vasilaki
Lab of Pharmacology, Faculty of Medicine, University of Thessaly, Larissa, Greece |
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| Citation | Sourlas, V., Athanasiou, V., Vasilaki, A.: Effect of somatostatinergic analogues on the ischemia-induced release of [3H]-D-Aspartate and [3H]-GABA from rat retina and hippocampus, Epitheorese Klin. Farmakol. Farmakokinet. 22(2): 327-328 (2008) | ||
| Publication Date | 23-25 May 2008 | ||
| Full Text Language | English | ||
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
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| Keywords | In vitro ischemia, retina, hippocampus, superfusion, somatostatin. | ||
| Other Terms | Review article | ||
| Summary | The modulation of the enhanced release of [3H]-D-Aspartate and [3H]GABA following ischemia-like conditions was studied in rat retinal and hippocampal preparations using a superfusion system. Ischemia was simulated by a glucose-free medium equilibrated with 95%N2/5%CO2. In this model the potential neuroprotective effect somatostatin on [3H]-D-Aspartate and [3H]GABA release induced by ischemia-like conditions were investigated. Retina was more resistant to ischemia compared to hippocampus. Somatostatin (SRIF-14) decreased ischemia-induced [3H]GABA release in both retina and hippocampus while the sst2/5 somatostatin receptor selective agonist Octreotide decreased and the sst2 somatostatin receptor selective antagonist D-Tyr8 CYN 154806 increased the ischemia-induced [3H]-D-Aspartate from both retinal and hippocampal preparations indicating that endogenous somatostatin plays a neuroprotective role in both tissues through sst2 receptor activation, at least as far as the ischemia-induced [3H]-D-Aspartate release is concerned. | ||
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| Relative Papers | |||
Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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