| Title | Serum pseudocholinesterase levels after chronic exposure to fenthion and correlation with morbidity: cancer, liver diseases, respiratory and neurological diseases | ||
| Authors | H. Souki1, G. Vrioni2, M. Katramadou1, D.G. Hela3 and H. Carageorgiou1
1. Pharmacology Department, Medical School, Athens University, Athens Greece 2. Microbiology Department, Medical School, Athens University, Athens Greece 3. School of Natural Resources and Enterprise Management Department of Food and Agriculture Business Administration, University of Ioannina, Ioannina Greece |
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| Citation | Souki, H., Vrioni, G., Katramadou, M., Hela, D.G., Carageorgiou, H.: Serum pseudocholinesterase levels after chronic exposure to fenthion and correlation with morbidity: cancer, liver diseases, respiratory and neurological diseases, Epitheorese Klin. Farmakol. Farmakokinet. 22(2): 329-335 (2008) | ||
| Publication Date | 23-25 May 2008 | ||
| Full Text Language | English | ||
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
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| Keywords | Pseudocholinesterase, fenthion, morbidity. | ||
| Other Terms | Review article | ||
| Summary | The widespread use of pesticides in Agriculture, public health and household environments results in continuous exposure of human populations. Organophosphates (Orps) are one of the main classes of insecticides used in Greece, especially in olive production. Orps inhibit Pseudocholinesterase (PChE) and Acetylcholinesterase (AChE) enzymes leading in overstimulation at cholinergic synapses. The determination of serum PChE activity is absolute and it is considered as a reliable index of Orps exposure in agricultural workers (sprayers). In the present study the serum PChE was determined: a) on one hundred (100) Agrinion farm workers before and after Fenthion (Orp) spraying and b) on 1848 Agrinion state Hospital patients( during the years 2003-2006) in order to assess a possible correlation of Orps chronic effect with co-existing diseases(cancer, respiratory diseases, liver and neurological diseases).Two control groups of the same epidemiological profile (age sex, nutritional habits, smoking, and age, sex, nationality, occupation, residence, insurance cover, nutritional habits and smoking) were consequently used. According to the results, the mean serum PChE activity of the Fenthion users was statistically depressed after spraying (7604 U/L) than before (9557 U/L) (p<0.001), and the reduction was dependent on the days of exposure (1-7 days) and the use or not of protective equipment. The mean serum PChE activity percentage change after Fenthion spraying was -26.9% (p<0.001). No complaints or health disturbances were recorded in any of the farm workers. Regarding the sample of patients (case group) the mean serum PChE activity was reduced (6103 U/L) compared to the control group (8978 U/L), and in particular, the mean serum PChE activity was 5707 U/L for those who suffered from cancer, 6060 U/L for those who suffered from respiratory diseases, 6378 U/L for those who suffered from liver diseases and 6448 for those who suffered from neurological diseases. Cancer and respiratory diseases are most frequent on those who are insured in OGA (Agriculture Insurance Organization) and on those who lived in rural areas (31.1%, and 29.6% respectively). In conclusion, the mean serum PChE activity is reduced after the exposure to Fenthion and the mean % change depends on the duration of exposure and the use of protective equipment. In addition, the mean serum PChE activity of patients is reduced in comparison to their control group (healthy urban people. Cancer and respiratory diseases are more frequent on those insured in OGA and on those living in rural areas. Correlation of the Orps chronic effect with morbidity, due to many other factors involved, is uncertain. | ||
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