| Title | Effects of sibutramine treatment on food intake, serum lipoproteins and TNF-α levels in rats fed standard laboratory or three isocaloric diets | ||
| Authors | Th. Stroubini1, A. Perelas1, Ch. Liapi1, D. Perrea2, I. Dontas2, M. Trapali1 and P. Galanopoulou1
1. Laboratory of Experimental Pharmacology and 2. Laboratory of Experimental Surgery and Surgical Research Christeas Hall, Medical School, University of Athens |
||
| Citation | Stroubini, T., Perelas, A., Liapi, C., Perrea, D., Dontas, I. et al.: Effects of sibutramine treatment on food intake, serum lipoproteins and TNF-α levels in rats fed standard laboratory or three isocaloric diets, Epitheorese Klin. Farmakol. Farmakokinet. 22(2): 339-342 (2008) | ||
| Publication Date | 23-25 May 2008 | ||
| Full Text Language | English | ||
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
pharmakonpress[at]pharmakonpress[.]gr |
||
| Keywords | TNF-α, sibutramine, high-protein diet, high-carbohydrate diet, high-fat diet. | ||
| Other Terms | Review article | ||
| Summary | The aim of the study was to explore the effects of macronutrients and Sibutramine(S) on serum TNF-α and lipoprotein levels in rats fed with standard laboratory or three isocaloric diets. 4 Groups of male Wistar rats (n=84) consumed High Fat Diet(HFD), High Carbohydrate Diet(HCD) and High Protein Diet(HPD) for 13 weeks. In the last 3 weeks each Group divided into 3 subgroups received vehicle, S 5 or 10mg/kg. Daily food intake was measured and serum lipoproteins and TNF-α were assayed. HFD was associated with higher daily food intake and TNF-α levels. Sibutramine administration significantly reduced serum triglycerides in the HCD group and food intake in the HFD group, while it did not affect serum TNF-α, HDL or LDL in any diet group at any dose. Results suggest that high-fat feeding is associated with a turn towards increased TNF- α production from adipose tissue and increased responsiveness to the anorectic effects of sibutramine. Contrary to what is observed in humans, S did not affect serum lipoprotein levels. | ||
| References | 1. Ryden M., Arner P.: Tumour necrosis factor-alpha in human adipose tissue – from signaling mechanisms to clinical implications. J. Intern. Med. 262: 431-438 (2007)
2. Guzik T.J., Mangalat D., Korbut R.: Adipocytokines – novel link between inflammation and vascular function? J. Physiol. Pharmacol. 57: 505-528 (2006) 3. Filippatos T.D., Kiortsis D.N., Liberopoulos E.N., Mik-hailidis D.P., Elisaf M.S.: A review of the metabolic effects of sibutramine. Curr. Med. Res. Opin. 21: 457-468 (2005) 4. Warwick Z.S.: Probing the causes of high-fat diet hyperphagia: a mechanistic and behavioral dissection. Neurosci. Biobehav. Rev. 20: 155-161 (1996) 5. Wynne K., Stanley S., McGowan B., Bloom S.: Appetite control. J. Endocrinol. 184: 291-318 (2005) 6. Mito N., Hosoda T., Kato C., Sato K.: Change of cytokine balance in diet-induced obese mice. Metabolism 49: 1295-1300 (2000) 7. Morin C.L., Eckel R.H., Marcel T., Pagliassotti MJ. High fat diets elevate adipose tissue-derived tumor necrosis factor-alpha activity. Endocrinology 138: 4665-4671 (1997) 8. Peiser C., McGregor G.P., Lang R.E.: Leptin receptor expression and suppressor of cytokine signaling transcript levels in high-fat-fed rats. Life Sci. 67: 2971-2981 (2000) 9. Perez-Matute P., Perez-Echarri N., Martinez J.A., Marti A., Moreno-Aliaga M.J.: Eicosapentaenoic acid actions on adiposity and insulin resistance in control and high-fat-fed rats: role of apoptosis, adiponectin and tumour necrosis factor-alpha. Br. J. Nutr. 97: 389-398 (2007) 10. Borst S.E., Conover C.F.: High-fat diet induces in-creased tissue expression of TNF-alpha. Life Sci. 77: 2156-2165 (2005) 11. Borst S.E., Conover C.F.: High-fat diet induces in-creased tissue expression of TNF-alpha. Life Sci. 77: 2156-2165 (2005) 12. Ainslie D.A., Proietto J., Fam B.C., Thorburn A.W.: Short-term, high-fat diets lower circulating leptin concentrations in rats. Am. J. Clin. Nutr. 71: 438-442 (2000) 13. Boozer C.N., Leibel R.L., Love R.J., Cha M.C., Aronne L.J.: Synergy of sibutramine and low-dose leptin in treatment of diet-induced obesity in rats. Metabolism 50: 889-893 (2001) 14. Strack A.M., Shu J., Camacho R., Gorski J.N., Murphy B., MacIntyre D.E., Hickey G.J.: Regulation of body weight and carcass composition by sibutramine in rats. Obes. Res. 10: 173-181 (2002) 15. Lichtenstein A.H.: Thematic review series: patient-oriented research. Dietary fat, carbohydrate, and protein: effects on plasma lipoprotein patterns. J. Lipid. Res. 47: 1661-1667 (2006) 16. Ferrer-Lorente R., Cabot C., Fernandez-Lopez J.A., Remesar X., Alemany M.: Effects of oleoylestrone with dexfenfluramine, sibutramine or phentermine on overweight rats. Eur. J. Pharmacol. 513: 243-248 (2005) 17. Murakami K., Bujo H., Unoki H., Saito Y.: High fat in-take induces a population of adipocytes to co-express TLR2 and TNF alpha in mice with insulin resistance. Biochem. Biophys. Res. Commun. 354: 727-734 (2007) 18. Fain J.N.: Release of interleukins and other inflammatory cytokines by human adipose tissue is enhanced in obesity and primarily due to the nonfat cells. Vitam. Horm. 74: 443-477 (2006) |
||
| Relative Papers | |||
Online ISSN 1011-6575
Άρθρα Δημοσιευμένα σε αυτό το Περιοδικό Καταχωρούνται στα:
- Chemical Abstracts
- Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
Συντακτικη Επιτροπή-Editorial Board
| ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 2008 – ANNUAL SUBSCRIPTION 2008 | |
| Γλώσσα Πλήρους Κειμένου – Full Text Language | Αγγλικά – English |
| Παραγγελία – Αγορά – Order – Buy | Ηλεκτρονική Μορφή: pdf (70 €) – Digital Type: pdf (70 €)
pharmakonpress[at]pharmakonpress[.]gr |
| Έντυπη Μορφή (70 € + έξοδα αποστολής) – Printed Type (70 € + shipping)
pharmakonpress[at]pharmakonpress[.]gr |
|