Τόμος 20 (2006) – Τεύχος 2 – Άρθρο 73 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 20 (2006) – Issue 2 – Article 73 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Title The effect of paroxetine on blood glucose level via potassium and/or calcium channels
Authors Efnan Muci¹, Cunay Ulku¹, Murat Kesim¹, Mine Kadioglu¹, Erdem Duman², Nuri I. Kalyoncu¹ and Ersin Yaris¹1. Department of Pharmacology,   2. Department of Anesthesiology, School of Medicine, Karadeniz Technical University, TURKEY
Citation Muci, E., Ulku, C., Kesim, M., Kadioglu, M., Duman, E. et al: The effect of paroxetine on blood glucose level via potassium and/or calcium channels, Epitheorese Klin. Farmakol. Farmakokinet. 20(2): 257-259 (2006)
Publication Date Accepted for publication: 19-20 May 2006
Full Text Language English
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Keywords Paroxetine, blood glucose level, insulin, potassium and calcium channels.
Other Terms review article
Introduction Tricyclic antidepressants and selective serotonin re-uptake inhibitors (SSRIs) are widely used in the treatment of many psychiatric diseases such as depression and panic disorders. They are also used in the treatment of depression and peripheral neuropathy seen in diabetic patients. Clinical and experimental trials have demonstrated that some of SSRIs have some suspicious effects on blood glucose levels in different directions. Especially fluoxetine, sertraline and fluvoxamine are studied in this point of view. But there is not any study investigating the effects of paroxetine at this regard. […]
References 1. Davis S.N.: Insulin, oral hypoglycemic agents, and the pharmacology of the endocrine pancreas. In: (Brunton L.L., Lazo J.S., Parker K.L., eds) Goodmann & Gilman’s, The Pharmacological Basis of Therapeutics. Eleventh Edition, pp. 1613-1645, Mc Graw Hill Companies, USA 2006

2. Kesim M., Duman E.N., Kadioglu M., Ulku C., Muci E., Kalyoncu N.I., Yaris E.: Antinociceptive effects of fluoxetine and paroxetine with their related actions on glycemia in mice. Neuro. Endocrinol. Lett: 2006 (in press)

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