| Title | Age-related changes of dopamine D2-like receptors in hippocampus, cerebellum and other brain areas of long-evans rats | |
| Authors | Nikolaos T. Panagopoulos and Nikolaos A. Matsokis
Lab. of Human and Animal Physiology, Dept. of Biology, University of Patras, Patras |
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| Citation | Panagopoulos, N.T., Matsokis, N.A.: Age-related changes of dopamine D2-like receptors in hippocampus, cerebellum and other brain areas of long-evans rats, Epitheorese Klin. Farmakol. Farmakokinet. 20(2): 264-267 (2006) | |
| Publication Date | Accepted for publication: 19-20 May 2006 | |
| Full Text Language | English | |
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| Keywords | Aging, hippocampus, cerebellum, D2 receptors, rat. | |
| Other Terms | review article | |
| Summary | The effect of aging in high affinity dopaminergic binding in the brain of Long-Evans rats was studied by using the specific D2-like receptor antagonist [³H]spiperone. Our data showed a statistically significant decrease in high affinity [³H]spiperone binding in hippo- campus, cerebellum, cerebral cortex and striatum of the aged (24 months), compared to young (3 months) rats. However, no changes in high affinity [³H]spiperone specific binding was observed in the midbrain and pons medulla. The above decreases reflect a decline in maximal density of D2-like receptor binding sites rather, than a change in the Kd value, since the Bmax values were significantly smaller compared to the young animals. The decreases of the D2-like dopamine receptors, seen in hippocampus, cerebellum, cerebral cortex and striatum, indicate a brain area specific decline of the dopaminergic system function during aging. | |
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Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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