| Title | Chemoprophylaxis in neurosurgery departments in Croatia and Greece | |
| Authors | P. Papaioannidou¹, K. Nanassis², V. Vlahovic-Palcevski³, D. Ledic⁴ and Ph. Tsitsopoulos²
1. Laboratory of Pharmacology, Medical School, Aristotle University of Thessaloniki, Greece 2. 2nd Clinic of Neurosurgery, Medical School, Aristotle University of Thessaloniki, Greece 3. Unit for Clinical Pharmacology, University Hospital of Rijeka, Croatia 4. Department of Neurosurgery, University Hospital Rijeka, Croatia |
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| Citation | Papaioannidou, P., Nanassis, Ν., Vlahovic-Palcevski, V., Ledic, D., Tsitsopoulos, Ph.: Chemoprophylaxis in neurosurgery departments in Croatia and Greece, Epitheorese Klin. Farmakol. Farmakokinet. 20(2): 289-291 (2006) | |
| Publication Date | Accepted for publication: 19-20 May 2006 | |
| Full Text Language | English | |
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| Keywords | Antibiotics, peri-operative chemoprophylaxis, CNS infections. | |
| Other Terms | review article | |
| Summary | The aim of the present study was to compare the status of Chemoprophylaxis in Neurosurgery Departments of two University Hospitals in Croatia and in Greece, and to check if general guidelines for Chemoprophylaxis in Neurosurgery are met. The Neurosurgery Clinic of the University Hospital Rijeka and the 2nd Clinic of Neurosurgery of the Hippokrateion Hospital of Thessaloniki were chosen for the study. The Croatian and Greek surgeons replied to the same questionnaire, which investigated the conformance to general guidelines and the behavior of the surgeons in Neurosurgical Chemoprophylaxis in patients having a low or a high risk for a post-surgical infection. The following issues in Chemoprophylaxis were checked: 1) application of chemoprophylaxis, 2) duration and time of initiation of chemoprophylaxis and 3) the kind of antibiotics used. In patients with a low risk for a post- surgical infection, Croatian surgeons do not use chemoprophylaxis in the following operations: closed craniocerebral injury, spinal injury, peripheral nerves injury, CNS tumors, hydrocephalus and vascular malformations. Greek surgeons use chemoprophylaxis in all kinds of Neurosurgery. In most cases chemoprophylaxis is initiated during pre-induction to anesthesia and its duration usually exceeds 24 hours. Both Croatian and Greek surgeons use a β-lactam for chemoprophylaxis but in some cases the Greek surgeons use also vancomycin when MRSA is suspected. In conclusions, the behavior of Croatian and Greek neurosurgeons in application of antimicrobial chemoprophylaxis reflects the status of microbial resistance in each country, as well as their fear for CNS infections. | |
| References | 1. Bratzler D.W., Houck P.M.: Antimicrobial prophylaxis for surgery: an advisory statement from the National Surgical Infection Prevention Project. Am. J. Surg. 189: 395-404 (2005)
2. Page C.P., Bohnen J.M., Fletcher J.R., et al.: Antimicrobial prophylaxis for surgical wounds. Guidelines for clinical care. Arch. Surg. 128: 79-88 (1993) 3. Mangram A.J., Horan T.C., Pearson M.L., et al.: Guideline for prevention of surgical site infection, 1999. Hospital Infection Control Practices Advisory Committee. Infect. Control Hosp. Epidemiol. 20: 250-278 (1999) 4. Finkelstein R., Rabino G., Mashiah T., et al.: Vancomycin versus cefazolin prophylaxis for cardiac surgery in the setting of a high prevalence of methicillin-resistant staphylococcal infections. J. Thorac. Cardiovasc. Surg. 123: 326-332 (2002) 5. Sessler D.I., Akca Ο.: Non-pharmacologic prevention of surgical wound infections. Clin. Infect. Dis. 35: 1397-1404 (2002) |
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| Relative Papers |
Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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