Τόμος 20 (2006) – Τεύχος 2 – Άρθρο 93 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 20 (2006) – Issue 2 – Article 93 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Title Non-adrenergic non-cholinergic relaxing effect of theophylline on the oesophagus and the lower oesophageal sphincter of the rabbit
Authors Theophano A. Psarra¹, Georgios C. Batzias¹, Theo L. Peeters² and Maria Koutsoviti-Papadopoulou¹

1. Laboratory of Pharmacology, Veterinary Faculty, Aristotle University, Thessaloniki, Greece

2. Gut Peptide Laboratory, Faculty of Medicine, University of Leuven, Belgium

Citation Psarra, Th.A., Batzias, G.C., Peeters, Th.L., Koutsoviti-Papadopoulou, K.: Non-adrenergic non-cholinergic relaxing effect of theophylline on the oesophagus and the lower oesophageal sphincter of the rabbit, Epitheorese Klin. Farmakol. Farmakokinet. 20(2): 305-307 (2006)
Publication Date Accepted for publication: 19-20 May 2006
Full Text Language English
Order – Buy  Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €) 

pharmakonpress[at]pharmakonpress[.]gr

Keywords Oesophagus, LOS, theophylline, PDE inhibitors, NANC (non-adrenergic, non-cholinergic), rabbit.
Other Terms review article
Summary The present study examines the effect of the widely used bronchodilator drug theophylline, a non-specific phosphodiesterase (PDE) inhibitor, on the rabbit oesophagus and lower oesophageal sphincter (LOS) contractility, and explores the mechanism of its action. According to the results theophylline, at concentrations higher than 3×10-5 M produces a concentration-dependent decrease in the tone and/or the phasic contractions of the rabbit oesophagus and LOS. This effect is not antagonised by adrenergic and cholinergic antagonists or by the ganglion-blocker hexamethonium (HEX), suggesting that it is non-adrenergic, non-cholinergic (NANG) and post-synaptic. In addition, L-NAME, an inhibitor of nitric oxide synthetase, fails to modify the theophylline’s relaxing effect. In conclusion, theophylline, at quite high concentrations, produces a post-synaptic, concentration-dependent NANG decrease in the tone and/or the phasic contractions of the rabbit oesophagus and LOS. There is evidence to suggest that this relaxing effect is due to cAMP elevation mediated through the inhibitory action of theophylline on the PDEs present in the LOS and oesophagus tissues.
References 1. Rabe K.F., Magnussen H., Dent G.: Eur. Respir. J. 8: 637-642 (1995)

2.  Goyal R.K., Rattan S.:  J. Clin.  Invest.  52:  337-341 (1973)

3. Fox J.A., Daniel E.E.: Am. J. Physiol. 237: E153-171 (1970)

4.   Tottrup A., Forman A., Madsen G., Andersson K.E.: Pharmacol. Toxicol. 67: 340-343 (1990)

5. Boswell-Smith V., Spina D., Page C.: Br. J. Pharmacol. 147: S252-257 (2006)

6. Barnette M.S., Torphy T.J., Grous M., Fink C., Ormsbee H.S.: J. Pharm. Exp. Ther. 249: 524-852 (1989)

7. Barnette M.S., Barone F.C., Fowler P.J., Grous M., Price W.J., Ormsbee H.S.: Gut 32: 4-9 (1991)

8. Kohjitani A., Shirakawa J., Okada S., Obara H.: Elsevier Science Inc 17: 927-931 (1996)

9. Osinki M.A., Bass P., Gaumnitz E.A.: Gastroenterology 114: A816 (1998)

10. Biancani P., Walsh J.H., Behar J.: J. Clin. Invest. 73: 963-967 (1984)

11. Rattan S., Gray M., Goyal R.: Life Sci. 30: 1157-563 (1982)

12. Murray J., Du C., Ledlow A., Bates J.N., Conklin J.L.: Am. J. Physiol. 261: G401-406 (1991)

13. Murray J., Bates J.N., Conklin J.L.: Dig. Dis. Sci. 39: 1872-1876 (1994)

14. Park H., Clark E., Conklin J.L.: Neurogastroenterol. Motil. 15: 625-633 (2003)

Relative Papers

Online ISSN 1011-6575

Άρθρα Δημοσιευμένα σε αυτό το Περιοδικό Καταχωρούνται στα:

Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor

Τι είναι η Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση-Οδηγίες προς τους Συγγραφείς – 
What is Epitheorese Klinikes Farmakologias 
και Farmakokinetikes-International Edition-Instrunctions to Authors

Άρθρα Δημοσιευμένα στην Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – 
Articles Published in Epitheorese Klinikes Farmakologias 
και Farmakokinetikes-International Edition

Συντακτικη Επιτροπή-Editorial Board

ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 2006 – ANNUAL SUBSCRIPTION 2006
Γλώσσα Πλήρους Κειμένου – Full Text Language Αγγλικά – English
Παραγγελία – Αγορά – Order – Buy Ηλεκτρονική Μορφή: pdf (70 €) – Digital Type: pdf (70 €)

pharmakonpress[at]pharmakonpress[.]gr

Έντυπη Μορφή (70 € + έξοδα αποστολής) – Printed Type (70 € + shipping)

pharmakonpress[at]pharmakonpress[.]gr

 

 

 

 

 

Bookmark the permalink.

Comments are closed.