| Title | Anticancer chemotherapeutic drugs are targeting selectively Cdt1 dependent cell cycle checkpoint | |
| Authors | Ath. Stathopoulou¹, V. Roukos², C. Petropoulou¹, C.S. Flordellis¹, Z. Lygerou² and S. Taraviras¹
1. Laboratory of Pharmacology and 2. Laboratory of General Biology, Department of Medicine, University of Patras, Rio, Patra, Greece |
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| Citation | Stathopoulou, A., Roukos, V., Petropoulou, C., Flordellis, C.S., Lygerou, Z. et al: Anticancer chemotherapeutic drugs are targeting selectively Cdt1 dependent cell cycle checkpoint, Epitheorese Klin. Farmakol. Farmakokinet. 20(2): 324-326 (2006) | |
| Publication Date | Accepted for publication: 19-20 May 2006 | |
| Full Text Language | English | |
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| Keywords | DNA damage, MMS, cisplatin, doxorubicin, checkpoint, Cdt1 regulation. | |
| Other Terms | review article | |
| Summary | DNA licensing during G1 phase ensures that chromosomal replication origins fire once per cell cycle and only after passage through mitosis. Cdt1 is one of the major components of the cell cycle licensing machinery. Cdt1 proteolysis in response to DNA damage is a novel evolutionarily conserved G1 checkpoint. In the present study, we investigate the effect of different anticancer chemotherapeutic drugs on Cdt1 regulation. | |
| References | 1. Xouri G., Lygerou Z., Nishitani H., Pachnis V., Nurse P., Taraviras S.: Cdt1 and geminin are down-regulated upon cell cycle exit and are over-expressed in cancer-derived cell lines. Eur. J. Biochem. 271: 3368-3378 (2004)
2. Karakaidos P., Taraviras S., Vassiliou L.V., Zacharatos P., Kastrinakis N.G., Kougiou D., Kouloukoussa M., Nishitani H., Papavassiliou A.G., Lygerou Z., Gorgoulis V.G.: Overexpression of the replication licensing regulators hCdt1 and hCdc6 characterizes a subset of non-small-cell lung carcinomas: synergistic effect with mutant p53 on tumor growth and chromosomal instability–evidence of E2F-1 transcriptional control over hCdt1. Am. J. Pathol. 165: 1351-1365 (2004) 3. Vaziri C., Saxena S., Jeon Y., Lee C., Murata K., Machida Y., Wagle N., Hwang D.S., Dutta A.: A p53-dependent check- point pathway prevents rereplication. Mol. Cell. 11: 997-1008 (2003) 4. Nishitani H., Lygerou Z., Nishimoto T., Nurse P.: The Cdt1 protein is required to license DNA for replication in fission yeast. Nature 404(6778): 625-628 (2000) 5 Arentson E., Faloon P., Seo J., Moon E., Studts J.M., Fremont D.H., Choi K.: Oncogenic potential of the DNA replication licensing protein CDT1. Oncogene 21: 1150-1158 (2002) 6. Nishitani H., Taraviras S., Lygerou Z., Nishimoto T.: The human homologue of Cdt1, a nuclear protein essential for replication licensing, accumulates in G1 and is destabilized after initiation of S phase in HeLa cells. J. Biol. Chem. 276: 44905-44911 (2001) 7. McGarry T.J., Kirschner M.W.: Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell 93: 1043-1053 (1998) 8. Lygerou Z., Nurse P.: License withheld: Geminin blocks DNA replication. Science 290: 2271-2273 (2000) 9. Zhou B.B.S., Elledge S.J.: The DNA damage response: putting checkpoints in perspective. Nature 408: 433-439 (2000) 10. Higa L.A., Mihaylov I.S., Banks D.P., Zheng J., Zhang H.: Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint. Nat. Cell Biol. 11:1008-1015 (2003) 11. Rogakou E.P., Pilch D.R., Orr A.H., lvanova V.S., Bonner W.M.: DNA double-stranded breaks induce histone H2AX phosphorylation on Serine 139. J. Biol. Chem. 273: 5858-5868 (1998) |
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| Relative Papers |
Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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