| Title | Dermatan sulfate induces matrix metalloproteinase-2 and stimulates the migration of human primary fibroblasts | |
| Authors | A. Sioga¹, D. Economou¹, L. Varinou¹, I. Klangas², E. Papakonstantinou², L. Economou¹ and G. Karakiulakis²
1. Department of Histology-Embryology and 2. Department of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, Greece |
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| Citation | Sioga, A., Economou, D., Varinou, L., Klangas, I., Papakonstantinou, E. et al: Dermatan sulfate induces matrix metalloproteinase-2 and stimulates the migration of human primary fibroblasts, Epitheorese Klin. Farmakol. Farmakokinet. 20(2): 319-321 (2006) | |
| Publication Date | Accepted for publication: 19-20 May 2006 | |
| Full Text Language | English | |
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| Keywords | Glycosaminoglycans, matrix metalloproteinase-2, fibroblasts, migration, wound healing. | |
| Other Terms | review article | |
| Summary | Glycosaminoglycans are extracellular matrix molecules which mediate a number of cellular functions such as proliferation, migration and response to growth factors. We have previously shown that hyaluronic acid (HA) enhances vascular smooth muscle cell migration via stimulation of matrix metalloproteinase (MMP)-2. In the present study, we investigated the effect of chondroitin sulphate A (CSA), dermatan sulphate (OS), chondroitin sulphate C (CSC) and HA on the migration of primary human lung fibroblasts in a wound healing model. We found that OS and HA stimulate in a dose- (1-50 µg) and time-(4-48 h) dependent manner the migration of fibroblasts. The OS-induced migration coincides with enhanced secretion of MMP-2, as revealed by gelatin zymography in aliquots of the supernatants of cell cultures. Our results indicate that OS is involved in the migration of fibroblasts and the secretion of MMP-2, and may offer an alternative target for pharmacological intervention in the process of wound healing. | |
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Online ISSN 1011-6575
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