| Title | Topical toll-like receptor agonists: a new era in cutaneous immunotherapy | |
| Authors | Dionysios Tsambaos¹, Antigoni Chaidaroglou², Theophilos Sakkis¹, Alexandros Sagriotis¹, Sophia Georgiou¹, George Batavanis¹, Efi Pasmatzi¹, Alexandra Monastirli¹, Panagiota Matsouka³ and Dimitrios Degiannis²
Departments of 1. Dermatology and 3. Haematology, University of Patras 2. Molecular Immunopathology Laboratory, Onassis Cardiac Surgery Center, Athens, Greece |
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| Citation | Tsambaos, D., Chaidaroglou, A., Sakkis, Th., Sagriotis, A., Georgiou, S. et al: Topical toll-like receptor agonists: a new era in cutaneous immunotherapy, Epitheorese Klin. Farmakol. Farmakokinet. 20(2): 341-343 (2006) | |
| Publication Date | Accepted for publication: 19-20 May 2006 | |
| Full Text Language | English | |
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| Keywords | Imidazoquinolines, imiquimod, toll-like receptors. | |
| Other Terms | review article | |
| Summary | Imidazoquinolines represent a recently developed class of toll-like receptor agonists who were found to exert distinct antiviral and antineoplastic effects in various animal models. Topical imiquimod, a representative of this class of compounds was found to stimulate the innate immune response and the cellular arm of the adaptive one, leading to potent antiviral, antitumor and immunoregulatory effects. An ever growing number of clinical trials clearly shows that imiquimod is an extremely efficient, well-tolerated, topical, patient-applied agent for the immunotherapy of cutaneous infections, neoplasms and autoimmune disorders, most of which previously represented frustrating therapeutic problems. The development and clinical application of topical toll-like receptor agonists, such as imiquimod, represents a new and spectacular era in cutaneous immunotherapy, comparable to that of synthetic retinoids in systemic dermatotherapy. | |
| References | 1. Armant M.A., Fenton M.J.: Toll-like receptors: a family of pattern-recognition receptors in mammals. Genome Biol. 3: 3011 (2002)
2. Beg A.A.: Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses. Trends Immunol 23: 509-512 (2002) 3. Hemmi H., Kaisho T., Takeuchi O., Sato S., Sanjo H., Hoshino K., Horiuchi T., Tomizawa H., Takeda K., Akira S.: Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat. Immunol. 3: 196- 200 (2002) 4. Sauder D.N.: Imiquimod: modes of action. Br. J. Dermatol. 149 (Suppl)66: 5-8 (2003) 5. Badavanis G., Monastirli A., Pasmatzi E., Tsambaos D.: Successful treatment of granuloma annulare with imiquimod cream 5%: a report of four cases. Acta Derm. Venereol. 85: 547-548 (2005) |
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| Relative Papers |
Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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| ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 2006 – ANNUAL SUBSCRIPTION 2006 | |
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