| Title | Effect of ketanserin on cadmium-induced acute hepatotoxicity | |
| Authors | Konstantinos N. Tzirogiannis¹, George K. Papadimas¹, Maria D. Demonakou², Michael G. Mykoniatis¹ and Georgios I. Panoutsopoulos¹
1. Department of Experimental Pharmacology, Medical School, Athens University, Athens 2. Histopathology Laboratory, Sismanoglion G.D. Hospital, Marousi, Attiki, Greece |
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| Citation | Tzirogiannis, K.N., Papadimas, G.K., Demonakou, M.D., Mykoniatis, M.D., Mykoniatis, M.G. et al: Effect of ketanserin on cadmium-induced acute hepatotoxicity, Epitheorese Klin. Farmakol. Farmakokinet. 20(2): 347-348 (2006) | |
| Publication Date | Accepted for publication: 19-20 May 2006 | |
| Full Text Language | English | |
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| Keywords | Apoptosis, cadmium, hepatocytes, hepatotoxicity, ketanserin. | |
| Other Terms | review article | |
| Summary | The protective effect of ketanserin, a 5-HT2 receptor antagonist, against cadmium liver injury was investigated. Male Wistar rats were injected intraperitoneally with a sublethal dose of cadmium (3.5 mg/kg body-weight). The rats were treated with normal saline (group I) or ketanserin (3 mg/kg bodyweight, group II) 2 h prior and 4 h after cadmium administration and killed at different time points. Hematoxylin-eosin (HE) stained liver sections were assessed for necrosis, apoptosis, peliosis, mitoses and inflammatory infiltration. Apoptosis was also quantified by the TUNEL assay (terminal deoxynucleotidyl transferase dUTP nick-end labeling). Nonparenchymal liver cells and activated Kupffer cells were identified histochemically. Necrosis, hepatocyte apoptosis, nonparenchymal cell apoptosis, macroscopic and microscopic peliosis were markedly reduced or minimized in ketanserin treated rats. Conclusively, ketanserin exerts a protective effect against acute cadmium-induced hepatotoxicity. | |
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