Τόμος 25 (2011) – Τεύχος 2 – Άρθρο 9 – Review of Clinical Pharmacology and Pharmacokinetics-Διεθνής Έκδοση – Volume 25 (2011) – Issue 2 – Article 9 – Review of Clinical Pharmacology and Pharmacokinetics -International Edition

Title Natural polyphenols from green tea and grape seed as photoprotective agents
Authors Vassiliki Raikou¹,², Evagelia Protopapa¹ and  Vassiliki Kefala¹

1. Division of Aesthetics and Cosmetology, School of Health and Caring Professions, Technological Educational Institution of Athens, Ag. Spyridonos Str. GR-12210 Egaleo, Athens, Greece

2. Department of Biology, National and Kapodistrian University of Athens, Panepistimioupolis, Zografou GR-15784, Athens, Greece

Citation Raikou, V., Protopapa, E., Kefala, V.: Natural polyphenols from green tea and grape seed as photoprotective agents, Epitheorese Klin. Farmakol. Farmakokinet. 25(2): 99-104 (2011)
Publication Date Accepted for publication (Final version): July 1, 2011
Full Text Language English
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Keywords Grape seed proanthocyanidins (GSPs), Oxidative stress, Photocarcinogenesis, Ultraviolet radiation, DNA repair, antioxidant, anti-inflammation, polyphenols, green tea polyphenol(GTP), cyclobutane pyrimidine dimmers(CPDs), epigallocate-chin-3-gallate (EGCG).
Other Terms review article
Summary Overexposure to UV radiation induces skin diseases or skin disorders, caused by the excessive induction of inflammation, oxidative stress and DNA damage, etc. The use of chemopreventive agents, such as plant polyphenols, to inhibit these events in UV-exposed skin is gaining attention. Chemoprevention refers to the use of agents that can inhibit, reverse, or retard the process of these harmful events in the UV-exposed skin. A wide variety of polyphenols or phytochemicals, most of which are dietary supplements, have been reported to possess substantial skin photoprotective effects. The polyphenols present in green tea as well as the proanthocyanidins present in grape seeds (Vitis vinifera) have been shown to have some biological effects, including prevention of photocarcinogenesis. The present review summurizes the in vitro and in vivo studies of the possible protective effect of specific polyphenols such us grape seed proanthocyanidins (GSPs) and green tea polyphenols (GTPs) and the molecular mechanism for these effects. It is also to determine the effect of topical application of GTP to human individuals against UV light-induced DNA damage in the form of cyclobutane pyrimidine dimers (CPDs) in the skin. UVB-induced CPDs were detected by immunohistochemical technique using monoclonal antibodies to thymine dimers. With the gradual increase in UVB dose, both erythema response and CPD formation in the skin was increased. GTP treatment inhibited both UVB-induced erythema response as well as CPD formation.
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