Τόμος 18 (2004) – Τεύχος 1 – Άρθρο 14 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 18 (2004) – Issue 1 – Article 14 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Title Prothymosin a suppresses the TGF-(31-enhanced production of tissue inhibitor of metalloproteinases- 1 but not of IL-6 in human synovial fibroblasts
Author G. Nezi1, M. Giannakouli1, S. Goura1, E, Panagiotopoulos3, A.P. Andonopoulos4, E. Giannopoulou2 and A.J. Aletras1

1Laboratory of Biochemistry, Department of Chemistry, and Departments of 2Pharmacology, 3Orthopaedic and 4Division of Rheumatology of the Department of Medicine, School of Medicine, University of Patras, Patras Greece

Citation Nezi, G., Giannakouli, M., Goura, S., Panagiotopoulos, E., Andonopoulos, A.P., et al.: Prothymosin a suppresses the TGF-(31-enhanced production of tissue inhibitor of metalloproteinases- 1 but not of IL-6 in human synovial fibroblasts, Epitheorese Klin. Farmakol. Farmakokinet. 18(1): 33-35 (2004)
Publication Date Accepted for publication: 2004
Full Text Language English
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Keywords TGF-β1, IL- 6, TIMP-1, Prothymosin α
Other Terms review article
Summary TGF-β1 is included among main cytokines involved in the regulation of pathogenesis of rheumatoid arthritis and osteoarthritis, and is considered that it plays a protective role. TGF-β1 (1ng/ml) significantly enhances the production of IL- 6 and TIMP-1 by human synovial fibroblast in a dose (0.01-1ng/ml) and time (12-48h incubation) dependent manner. Using specific protein kinases inhibitors, it is shown that this process is mediated by protein kinase C. Prothymosin a, a bioactive acid peptide, detected in synovial membrane and fluid, dose-dependently (0.1-1pg/ml) suppresses the TGF-β1 -enhanced production of TIMP-1 but not of IL-6 by fibroblasts. The role of prothymosin a in arthritis may be considered as pro-inflammatory.
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