| Title | Corticotropin-releasing factor (CRF) receptors in the gastrointestinal system: physiological and pharmacological implications | |
| Author | Ekaterini Chatzaki1,3, Yvette Taché2 and Dimitri E. Grigoriadis1
1Neurocrine Biosciences Inc., San Diego, CA 92121, 2Center for Ulcer Research and Education: UCLA, CA 90073, 3Dept. Pharmacology, Medical School, DUTH, GR 68100 |
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| Citation | Chatzaki, E., Taché, Y. and Grigoriadis, D.E.: Corticotropin-releasing factor (CRF) receptors in the gastrointestinal system: physiological and pharmacological implications, Epitheorese Klin. Farmakol. Farmakokinet. 18(1): 73-75 (2004) | |
| Publication Date | Accepted for publication: 2004 | |
| Full Text Language | English | |
| Order – Buy | Ηλεκτρονική Μορφή: pdf (20 €) – Digital Type: pdf (20 €) pharmakonpress[at]pharmakonpress[.]gr | |
| Keywords | Corticotropin-releasing Factor, CRF receptor, Gastrointestinal System | |
| Other Terms | review article | |
| Summary | Corticotropin-releasing factor (CRF) receptor agonists administered peripherally inhibit gastric emptying while stimulating colonic propulsive motility and fecal output in experimental animals. In addition, endogenous CRF-related peptides are found throughout the gastrointestinal (Gl). We developed new specific antibodies that recognize selectively the two CRF receptor types, CRF1 and CRF2 and used them for the mapping of the receptor proteins throughout the rat Gl. Both CRF receptor subtype proteins were found in the upper and lower Gl tissues, providing direct evidence of a significant implication in the physiology of this system through peripheral mechanisms, while distinct expression patterns suggest differential functions. Our findings support a pharmacological potential of novel small- molecule CRF antagonists in the prophylaxis and/or treatment of stress-related Gl disorders. | |
| References | 1. Vale W., Spiess J., Rivier C., Rivier J.: Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science 213: 1394-1397(1981)
2. Grigoriadis D.E., Lovenberg T.W., Chalmers D.T., Liaw C., De Souza E.B.: Characterization of corticotropin-releasing factor receptor subtypes. Ann. N.Y. Acad. Sci. 780: 60-80 (1996) 3. Tache Y.t Martinez V., Million M., Wang L.: Stress and the gastrointestinal tract III. Stress-related alterations of gut motor function: role of brain corticotropin-releasing factor receptors. Am. J. Physiol. Gastrointest. Liver Physiol. 280′. G173-177 (2001) 4. Gabry K.E., Chrousos G.P., Rice K.C., et al.: Marked suppression of gastric ulcerogenesis and intestinal responses to stress by a novel class of drugs. Mol. Psychiatry 7: 474-483 (2002) 5. Chatzaki E., Charalampopoulos I., Leontidis C., et al.: Urocortin in human gastric mucosa: relationship to inflammatory activity. J. Clin. Endocrinol. Metab. 8&. 478-83 (2003) |
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| Relative Papers |
Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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