| Title | Effect of trimetazidine on the fine stucture of ischaemic rat fast and slow muscles | |
| Author | L. Economou1, A. Sioga1, T. Loizidis2 and M. Albani2
1Laboratory of Histology-Embryology and 2Laboratory of Physiology, Medical School, Aristotle University, Thessaloniki, Greece |
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| Citation | Economou, L., Sioga, A., Loizidis, T. and Albani, M.: Effect of trimetazidine on the fine stucture of ischaemic rat fast and slow muscles, Epitheorese Klin. Farmakol. Farmakokinet. 18(1): 105-107 (2004) | |
| Publication Date | Accepted for publication: 2004 | |
| Full Text Language | English | |
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €) pharmakonpress[at]pharmakonpress[.]gr | |
| Keywords | Trimetazidine, TMZ, Ischaemic, fast and low muscles, fine structure | |
| Other Terms | review article | |
| Summary | The present study sought to examine the effects of an antioxidant on the fine structure of chronic ischaemic fast and stow muscles. 16 Wistar rats were used in this study, and half of them underwent unilateral ligation of the right common iliac artery. Trimetazidine (TMZ) was administered for two weeks intraperitoneally. EM evaluation showed no significant changes in the fine structure of EDL and soleus muscles. | |
| References | 1. Maridonneau-Parini i., Band L., Housset B., Harpey C.: Effect of TMZ on membrane damage induced by oxygen free radicals in human red cells. Br. J. Clin. Pharmacol. 20. 148-151 (1985)
2. Kiyosue T., Nakamura S., Arita M.: Effects of Trimetazidine on action potentials and membrane currents of guinea-pig ventricular myocytes. J. Mol. Cell Cardiol. 1&. 1301-1311 (1986) 3. Kenshiro Ikebe, Teiji Kato, Makio Yamaga, Jun Hirose, Toru Tsuchida, and Katsumasa Takagi. Increased ischemia-reperfusion blood flow impairs the skeletal muscle contractile function. J. Surg. Res. 99. 1 -6 (2001) 4. Zerba E., Komorowske T.E., Faulkner J.A.: Free radical injury to skeletal muscles of young, adult, and old mice. Am. J. Physiol. 258. C429-C435 (1990) 5. Wijnen M.H.W.A., Coolen S.A.J., Vader H.L., Reijenga J.C., Hulf F.A., Roumen R.M.: Antioxidants reduce oxidative stress in claudicants. J. Surg. Res. 9&. 183-187 (2001) 6. Albani M., Megalopoulos A., Kiskinis D., Parashos S., Grigoriadis N., Guiba-Tziampiri O.: Morphological, histochemical, and interstitial pressure changes in the muscle before and after aortofemoral bypass in patients with pe-ripheral arteria; occlusive disease. BMC Musculoskeletal Disorders Vol. 3, 2002 |
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| Relative Papers |
Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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| ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 2004 – ANNUAL SUBSCRIPTION 2004 | |
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