Tag Archives: synthesis

Review of Clinical Pharmacology and Pharmacokinetics – International Edition Volume 38 (2024) – Supplementary Issue 2

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A straightforward and sensitive method for high-performance liquid chromatography (HPLC) was created in order to separate and identify the di-stereoisomeric mixture of a spiro-oxalidinonic derivative of sorbinil. Continue reading →

Τόμος 34 (2020) – Τεύχος 1 –Άρθρο 2 – Review of Clinical Pharmacology and Pharmacokinetics – Διεθνής Έκδοση – Volume 34 (2020) – Issue 1 – Article 2 – Review of Clinical Pharmacology and Pharmacokinetics – International Edition

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The heme enzyme soluble Guanylate Cyclase (sGC) is a pivotal amplification target in the NO-sGC-cGMP pathway, converting guanosine-5΄-triphoshate (GTP) to cyclic guanosine-3΄,5΄-monophosphate (cGMP) in response to its major physiological stimulant, nitric oxide (NO). Continue reading →