Τόμος 35 (2021) – Τεύχος 2 –Άρθρο 2 – Review of Clinical Pharmacology and Pharmacokinetics – Διεθνής Έκδοση – Volume 35 (2021) – Issue 2 – Article 2 – Review of Clinical Pharmacology and Pharmacokinetics – International Edition

Title

Prenatal and perinatal causes, risk factors, diagnosis and prevention of neonatal cerebral palsy

Author

Anastasia Bothou, Georgios Iatrakis, Aggeliki Gerende, Nikolaos Nikolettos, Panagiotis Tsikouras, Stefanos Zervoudis

Department of Midwifery, University of West Attica (UniWA), Athens, Greece
Neonatal Department, “Alexandra” General Hospital, Athens, Greece

REA Hospital, Athens, Greece
Department of Obstetrics and Gynecology, Democritus University of Thrace, Alexandroupolis, Greece

Citation

A. Bothou, G. Iatrakis, A.Gerende, N. Nikolettos, P. Tsikouras, S. Zervoudis. Prenatal and perinatal causes, risk factors, diagnosis and prevention of neonatal cerebral palsy. Review Clin. Pharmacol. Pharmacokinet. 2021, 35, 2, 47-53. DOI:10.5281/zenodo.10048458

Publication Date
Republication Date
14-07-2021
27-10-2023
Full Text Language

English

DOI:10.5281/zenodo.10048458

Keywords
cerebral palsy, neonatal paralysis, childhood disability, prenatal causes, perinatal causes
Other Terms

Study

Summary
Cerebral Palsy (CP) is a major cause of neonatal and childhood disability and is closely linked to pregnancy and perinatal period. CP is a group of developmental movement or posture disorders, which are due to non-progressive damage to the developing brain and lead to reduced activity and other nervous system functions such as learning, hearing, seeing, and thinking. This article deals with the epidemiology, etiology, risk factors, diagnosis and prevention of CP.
References 1. Barkoudah E, Glader L. Cerebral palsy: Epidemiology, etiology, and prevention. UpToDate, 2021.
2. Morris C. Definition and classification of cerebral palsy: a historical perspective. Dev Med Child Neurol 2007; 49: 3–7.
3. Badawi N, Mcintyre S, Hunt R. Perinatal care with a view to preventing cerebral palsy. Dev Med Child Neurol. 2021 Feb; 63: 156-161.
4. Paneth N, Ting Hong T, Korzeniewski S. The Descriptive Epidemiology of Cerebral Pulsy. Clinics in Perinatology 2006; 33: 251-67.
5. Aravamuthan B, Fehlings D, Shetty S, Fahey M, Gilbert L, Tilton A, Kruer M. Variability in Cerebral Palsy Diagnosis. Pediatrics. 2021 Feb; 147: e2020010066.
6. Torfs CP, vanden Berg B, Oechsli FW, Cummins S. Prenatal and perinatal factors in the etiology of cerebral palsy. J. Pediatr 1990; 116:615-9.
7. Himmelmann K, Hagberg G, Beckung E, Hagberg B, Uvebrant P. The changing panorama of cerebral palsy in Sweden. IX. Prevalence and origin in the birth-year period 1995-1998. Acta Paediatr. 2005 Mar; 94: 287-94.
8. Jarvis S, Glinianaia SV, Torrioli MG, Platt MJ, Miceli M, Jouk PS, Johnson A, Hutton J, Hemming K, Hagberg G, Dolk H, Chalmers J, Surveillance of Cerebral Palsy in Europe (SCPE) collaboration of European Cerebral Palsy Registers. Cerebral palsy and intrauterine growth in single births: European collaborative study. Lancet. 2003 Oct 4; 362: 1106-11.
9. Petersen MC, Palmer FB. Birthweight and risk for cerebral palsy. Lancet. 2003 Oct 4;362: 1089-90.
10. Scher A, Petterson B, Blair E, Ellenberg J, Grether J, Haan E, Reddihough D, Yeargin-Allsopp M., Nelson K. The risk of mortality or cerebral palsy in twins: a collaborative population-based study. Pediatr Res. 2002 Nov; 52: 671-81.
11. Bejar R, Vigliocco G, Gramajo H, Solana C, Benirschke K, Berry C, Coen R, Resnik R. Antenatal origin of neurologic damage in newborn infants. II. Multiple gestations. Am J Obstet Gynecol. 1990 May;162: 1230-6.
12. Perlman JM. Brain injury in the term infant. Semin Perinatol. 2004 Dec; 28:415-24.
13. Cowan F, Rutherford M, Groenendaal F, Eken P, Mercuri E, Bydder GM, Meiners LC, Dubowitz L, Vries L. Origin and timing of brain lesions in term infants with neonatal encephalopathy. Lancet. 2003 Mar, 1; 361: 736-42.
14. American College of Obstetricians and Gynecologists. Task Force on Nenonatal Encephalopathy and Cerebral palsy. Washington, DC: American College of Obstetricians and Gynecologist; 2003.
15. Gardella C, Taylor M, Benedetti T, Hitti J, Critchlow C. The effect of sequential use of vacuum and forceps for assisted vaginal delivery on neonatal and maternal outcomes. Am J Obstet Gynecol. 2001 Oct; 185: 896-902.
16. Noetzel M. Perinatal trauma and cerebral palsy. Clin Perinatol. 2006 Jun; 33: 355-66.
17. Kirton A, deVeber G. Cerebral palsy secondary to perinatal ischemic stroke. Clin Perinatol. 2006 Jun; 33: 367-86.
18. Lee J, Croen L, Backstrand KH, Yoshida C, Henning L, Lindan C, Ferriero D, Fullerton H, Barkovich AJ, Wu Y. Maternal and infant characteristics associated with perinatal arterial stroke in the infant. JAMA. 2005 Feb 9; 293: 723-9.
19. Menkes J, Flores-Sarnat L. Cerebral palsy due to chromosomal anomalies and continuous gene syndromes. Clin Perinatol. 2006 Jun; 33: 481-501.
20. Naeye RL, Lin HM. Determination of the timing of fetal brain damage from hypoxemia-ischemia. Am J Obstet Gynecol. 2001 Jan; 184: 217-24.
21. Abel E. Cerebral Palsy and Alcohol Consumption during Pregnancy: Is There a Connection? Alcohol and Alcoholism, Volume 45, Issue 6, November-December 2010, Pages 592–594.
22. Persson M, Johansson S, Villamor E, Cnattingius S. Maternal overweight and obesity and risks of severe birth-asphyxia-related complications in term infants: a population-based cohort study in Sweden. PLoS Med. 2014; 11:e1001648 Epub 2014/05/23. 10.1371/journal.pmed.1001648;
23. McPherson JA, Smid MC, Smiley S, Stamilio DM. Association of Maternal Obesity with Child Cerebral Palsy or Death. American Journal of Perinatology. 2017;34: 563–7. 10.1055/s-0036-1594015.
24. Zhu T, Tang J, Zhao F, Qu Y, Mu D. Association between maternal obesity and offspring Apgar score or cord pH: a systematic review and meta-analysis. Sci Rep. 2015;5:18386 Epub 2015/12/23. 10.1038/srep18386.
25. Kanadys WM, Leszczynska-Gorzelak B, Jedrych M, Oleszczuk J. [Maternal pre-pregnancy obesity and the risk of preterm birth: a systematic overview of cohort studies with meta-analysis]. Ginekol Pol. 2012;83: 270–9. Epub 2012/06/21.
26. Edlow AG. Maternal obesity and neurodevelopmental and psychiatric disorders in offspring. Prenatal Diagnosis. 2017;37: 95–110. 10.1002/pd.4932.
27. Pan C, Deroche CB, Mann JR, McDermott S, Hardin JW. Is prepregnancy obesity associated with risk of cerebral palsy and epilepsy in children? J Child Neurol. 2014; 29: Np196–201. Epub 2013/12/18. 10.1177/0883073813510971.
28. Xiao D, Qu Y, Huang L, Wang Y, Li X, Mu D. Association between maternal overweight or obesity and cerebral palsy in children: A meta-analysis. PLoS One. 2018; 13: e0205733.
29. Mor O, Stavsky M, Yitshak-Sade M, Mastrolia S, Beer-Weisel R, Rafaeli-Yehudai , Besser L, Hamou B, Mazor M, Erez O. Early onset preeclampsia and cerebral palsy: a double hit model? Am J Obstet Gynecol 2016 Jan; 214: 105.e1-9.
30. Moster D, Lie RT, Irgens LM, Bjerkedal T, Markestad T. The association of Apgar score with subsequent death and cerebral palsy: A population-based study in term infants. J Pediatr. 2001 Jun; 138: 798-803.
31. Thygesen SK, Olsen M, Østergaard JR, Sørensen HT. Respiratory distress syndrome in moderately late and late preterm infants and risk of cerebral palsy: a population-based cohort study. BMJ Open. 2016; 6: e011643.
32. Stoll BJ, Hansen NI, Adams-Chapman I, Fanaroff A, Hintz SR, Vohr B, Higgins RD, National Institute of Child Health and Human Development Neonatal Research Network. Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection. JAMA. 2004 Nov 17; 292: 2357-65.
33. Doyle L, Halliday HL, Ehrenkranz RA, Davis PG, Sinclair JC. Impact of postnatal systemic corticosteroids on mortality and cerebral palsy in preterm infants: effect modification by risk for chronic lung disease. Pediatrics. 2005 Mar; 115: 655-61.
34. Peebles D, Wyatt J. Synergy between antenatal exposure to infection and intrapartum events in causation of perinatal brain injury at term. BJOG. 2002 Jul; 109: 737-9.
35. Hermansen MC, Hermansen MG. Perinatal infections and cerebral palsy. Clin Perinatol. 2006 Jun; 33: 315-33.
36. Perlman JM. Intrapartum asphyxia and cerebral palsy: is there a link? Clin Perinatol. 2006 Jun; 33: 335-53.
37. Nelson KB, Willoughby RE. Infection, inflammation and the risk of cerebral palsy. Curr Opin Neurol. 2000 Apr; 13: 133-9.
38. King A, Machipisa C, Finlayson F, Fahey M, Novak I, Malhotra A. Early detection of cerebral palsy in high-risk infants: Translation of evidence into practice in an Australian hospital. J Paediatr Child Health. 2021 Feb; 57: 246-250.
39. Mirmiran M, Barnes PD, Keller K, Constantinou JC, Fleisher BE, Hintz SR, Ariagno RL. Neonatal brain magnetic resonance imaging before discharge is better than serial cranial ultrasound in predicting cerebral palsy in very low birth weight preterm infants. Pediatrics. 2004 Oct; 114: 992-8.
40. Lockwood CJ, Magriples U. Prenatal care: Initial assessment. UpToDate, 2021.
41. Bachnas MA, Akbar M, Dachlan E, Dekker G. The role of magnesium sulfate (MgSO 4) in fetal neuroprotection. J Matern Fetal Neonatal Med. 2021 Mar; 34: 966-978.
42. O’Shea TM. Diagnosis, treatment, and prevention of cerebral palsy. Clin Obstet Gynecol. 2008 Dec; 51: 816-28.
43. Panagiotou E, Tsikouras P, Bothou A, Fotopoulos S, Zervoudis S, Deuteraiou D, Chalil AB, Trypsianis G, Galazios G. A comparative study of the contribution of antenatal corticosteroids administration on improving neonatal respiratory function after elective cesarean section. Clinical and Experimental Obstetrics & Gynecology 2019, Vol. 46 Issue (3): 368-374.
44. French NP, Hagan R, Evans S, Mullan A, Newnham JP. Repeated antenatal corticosteroids: effects on cerebral palsy and childhood behavior. Am J Obstet Gynecol. 2004 Mar; 190: 588-95.
45. Shepherd E, Salam R, Middleton P, Makrides M, McIntyre , Badawi N, Crowther C. Antenatal and intrapartum interventions for preventing cerebral palsy: an overview of Cochrane systematic reviews. Cochrane Database Syst Rev. 2017 Aug 8; 8: CD012077.
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