Τόμος 32 (2014) – Τεύχος 1 – Άρθρο 3 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 32 (2014) – Issue 1 – Article 3 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition


Τίτλος – Title

Καταγραφή Εργαστηριακών και Κλινικών Δοκιμών Aξιολόγησης Σύγχρονων Μεθόδων Απολύμανσης και Αποστείρωσης
Evaluation of Laboratory and Clinical Trials for Modern Methods of Disinfection and Strerilization

Συγγραφέας – Author

Κ. Ντελέζος, Ε. Μέντζιου, Α. Κούτου, Ν. Τσιμπέκου, Α. Νεστορίδου
Τμήμα Δημόσιας Υγιεινής, Σxολή Επαγγελμάτων Υγείας και Πρόνοιας, Τεχνολογικό Εκπαιδευτικό Ίδρυμα (ΤΕΙ) Αθήνας, Αιγάλεω, Αθήνα, Ελλάς –
K. Ntelezos, E. Mentziou, A. Koutou, N. Tsimpekou, K. Nestoridou
Department of Public Health, Faculty of Health and Caring Profesions, Tecnological Educational Institution (TEI) of Athens, Egaleo, Athens, Hellas

Παραπομπή – Citation

Ντελέζος Κ., Μέντζιου Ε., Κούτου Α., Τσιμπέκου Ν.,  Νεστορίδου Α.: Καταγραφή Εργαστηριακών και Κλινικών Δοκιμών Aξιολόγησης Σύγχρονων Μεθόδων Απολύμανσης και Αποστείρωσης, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 32: 25-40 (2014)
Ntelezos K. , Mentziou E. , Koutou A. , Tsimpekou N. , Nestoridou K.: Evaluation of Laboratory and Clinical Trials for Modern Methods of Disinfection and Strerilization, Epitheorese Klin. Farmakol. Farmakokinet. 32: 25-40 (2014)

Ημερομηνία Δημοσιευσης – Publication Date
15 Μαρτίου 2014 – 2014-03-15
Γλώσσα Πλήρους Κειμένου –
Full Text Language

Ελληνικά – Greek

Παραγγελία – Αγορά –
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Λέξεις κλειδιά – Keywords
Aπολύμανση, κλινική δοκιμή, υπεριώδης μικροβιοκτόνος ακτινοβολία (UVGI), χαλκός, άργυρος, υπεροξείδιο του υδρογόνου, ορθοφθαλαλδεϋδη (OPA), διχλωροϊσοκυανουρικό νάτριο, σύστημα αποστείρωσης Στέρις 1 Ε, πολυεξανίδιο
Disinfection, sterilization, the ultraviolet germicide rays (UVGI), copper, silver, vaporized hydrogen peroxide, tablets of dichloroisocyanyrate sodium, the sterilization system Steris 1E , polehexanide, orthophalaldehyde (OPA)
Λοιποί Όροι – Other Terms

άρθρο επισκόπησης, μέθοδοι απολύμανσης και αποστείρωσης, πλεονεκτήματα, απολύμανση του αέρα, απολύμανση του νερού, απολύμανση των επιφανειών, απολύμανση των τροφίμων, μικροβιοκτόνα δράση, μικροβιοστατική δράση, κλινικές μελέτες, εργαστηριακές μελέτες, ορισμός, μικροβιοκτόνος ακτίνα, Διεθνής Επιτροπή Διαφωτισμού, Κέντρο Ελέγχου Ασθενειών, απολύμανση του νερού με υπεριώδη μικροβιοκτόνο ακτινοβολία (CIE), υπεριώδης ακτινοβολία C (UVC), κλιματιστικά, εξαερισμός, συστήματα φιλτραρίσματος, εναέρια συστήματα απολύμανσης χειρουργικών αιθουσών, χειρουργικό τραπέζι, Κατηγορία O, αντικατάσταση  του χλωρίου, συστήματα απολύμανσης εξοπλισμού, χειρουργικός εξοπλισμός, ιατρικός εξοπλισμός, ρούχα, ιματισμός, Κατηγορία E,  Φορητά συστήματα απολύμανσης, μικροβιακοί παράγοντες , Κατηγορία M,  Φορητές μονάδες υπεριώδους μικροβιοκτόνου ακτινοβολίας, τοίχοι, επιφάνειες, Κατηγορία P, μακράς ενεργοποίησης  απολύμανση, ανοιχτοί χώροι , Κατηγορία H, Προστασία των τροφίμων και ποτών, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,,
review article, advantages, air disinfection, water disinfection, surface disinfection, food disinfection, clinical studies, laboratory studies, ultraviolet C rays (UVC),

Περίληψη – Summary

Τα τελευταία έτη παρατηρείται συνεχής προσπάθεια εξέλιξης και ανακάλυψης νέων αποτελε-σματικότερων μεθόδων απολύμανσης και αποστείρωσης στον αγώνα προάσπισης της Δημόσιας Υγείας. Οι κυριότερες μέθοδοι που έχουν δημοσιευτεί και εφαρμοστεί με επιτυχία από το έτος 2000 είναι: η υπεριώδης μικροβιοκτόνος ακτινοβολία, ο χαλκός, ο άργυρος, το υπεροξείδιο του υδρογόνου, η ορθο-φθαλαλδεϋδη, το διχλωροϊσοκυανουρικό νάτριο, το σύστημα αποστείρω-σης Στέρις 1Ε, το πολυεξανίδιο. Για κάθε μια από τις με-θόδους αναδεικνύoνται τα πλεονεκτήματα τους έναντι των άλλων μεθόδων. Π.χ., τα συστήματα υπεριώδους μικροβιοκτόνου ακτινοβολίας απολυμαίνουν τον αέρα, το νερό, τις επιφάνειες και τα τρόφιμα. Ο χαλκός έχει ισχυρή μακροχρόνια μικροβιοκτόνο και μικροβιοστατική δράση. Ο άργυρος χρησιμοποιείται ως εναλλακτική λύση απολύμανσης σε εφαρμογές που η χρήση των παραδοσιακών απολυμαντικών μειονεκτεί.

A continuous effort for progress and invention of new, more effective, methods of disinfection and sterilization is observed at the last few years in the combat of disease prevention. The main methods that have been published and successfully applied, since year 2000, are: the ultraviolet germicide rays, copper, silver, vaporized hydrogen peroxide, tablets of dichloroisocyanyrate sodium, the sterilization system Steris 1E and polehexanide. There is an elevation of the advantages of each method against the other methods, for example: ultra-violet germicide rays disinfect the air, water, surfaces and food. Copper has a strong long lasting germicide and microbiostatic action. Silver is being used as an alternative disinfection solution in applications that the use of traditional disinfectants is inconvenient. Orthophalaldehyde is used for high level disinfection. Dichloroisocyanurate sodium is the safest alternative chloride form for high level disinfection. Hydrogen peroxide has antiseptic, disinfection and sterilization properties. Sterilization system Steris 1E could be used for processing thermosensitive medical devices. Finally, polyhexanide is an expanded and significantly effective disinfectant and antiseptic. The new methods of disinfection and sterilization offer a lot of advantages, nevertheless, it is essential to be developed further and more detailed efforts especially in pilot surveys, planning and epidemiological studies in order to gain the trust of market and contribute to a great decrease of infections.

Αναφορές – References
1. Brickner P.W., Vincent R.L., First M.W, Nadel E.A., Murray M., Kaufman W.: The application of ultraviolet germicidal irradiation to control transmission of airborne disease: Bioterrorism countermeasure. Public Health Reports 118: 99-114 (2003)2. IUVA: General Guideline for UVGI Air and Surface Disinfection Systems. IUVA-G01A-2005 International Ultraviolet Association, Ayr, Ontario, Canada, 20053. Bahnfleth W.P., Kowalski W.J., Freihaut J.: Standard and guideline requirements for UVGI air treatment systems. In: Proceedings of Indoor Air 2005 (10th International Confe-rence on Indoor Air Quality and Climate. Pp. 3464-3468, 20054. Sweeney C.P., Dancer S.J.: Can hospital computers be disinfected using a hand-held UV light source? J. Hosp. Infect. 72: 92-94 (2009)

5. Rutala W.A.: Disinfection and Sterilization: Current Issues and New Technology. Chicago APIC Fall Education Program, October 8, 2010

6. FDA: Procedures for the Safe and Sanitary Processing and Importing of Juice. Fed. Reg. 66: 6137-6202 (2001)

7. Fletcher L.A., Noakes C.J., Beggs C.D., Sleigh P.A.: The importance of bioaerosols in hospital infections and the potential for control using germicidal ultraviolet irradiation. In: (Monedero M.A.S., Garcia-Ferrandez A.R, eds) Pro-ceedings of the 1st Seminar on Applied Aerobiology, Murcia, Spain, 20th May 2004. 1st Seminar on Applied Aerobiology, 20 May 2004, Murcia, Spain. Centro de Edafología y Biología Aplicada del Segura, Spain

8. Andersen B.M., Bånrud H., Bøe E., Bjordal O., Dran-gsholt F.: Comparison of UV C light and chemicals for disinfection of surfaces in hospital isolation units. Infect. Control Hosp. Epidemiol. 27: 729-734 (2006)

9. Rastogi V.K., Wallace L., Smith L.S.: Disinfection of Acinetobacter baumannii-contaminated surfaces relevant to medical treatment facilities with ultraviolet C light. Mil. Med. 172: 1166-1169.

10. Sylvain D., Tapp L.: Health Hazard Evaluation Report HETA 20070257-3082. Brigham and Women’s Hospital Boston, Massachusetts, May 2009. In: http://www.cdc.gov/niosh/hhe/

11. Russell A.D, Hugo W.B.: Antimicrobial activity and action of silver. Prog. Med. Chem. 31: 351-370 (1994)

12. Michels H.T., Wilks S.A., Keevil, C.W.: The Antimi-crobial Effects of Copper Alloy Surfaces on the Bacterium E. coli O157:H7. Proceedings of Copper 2003 – Cobre 2003, The 5th International Conference, Santiago, Chile, Vol. 1 – Plenary Lectures, Economics and Applications of Copper, pp. 439-450, The Canadian Institute of Mining, Metallurgy and Petroleum, Montreal, Quebec, Canada, (presented in Santiago, Chile, November 30 – December 3, 2003

13. Greek Copper Institute (March 2010) In: http//www.copper.org.gr

14. Borkow G., Gabbay J.: Copper, an ancient remedy returning to fight microbial, fungal and viral infections. Curr. Chem. Biol. 3: 272-278 (2009)

15. Greek Copper Institute (May 2010) In: http//www.copper.org.gr

16. Afkhami A., Soltani-Felehgari F., Madrakian T., Ghaedi H., Rezaeivala M.: Fabrication and application of a new modified electrochemical sensor for simultaneous determination of copper ions in foodstuff samples. Anal. Chim. Acta. 771: 21-30 (2013)

17. Αntimicrobial copper official site, Clarification of US Cli-nical Trials, 2011. In: http://www.antimicrobialcopper.com

18. Salgado C.D., Morgan A., Sepkowitz K.A., et al.: A pilot study to determine the effectiveness of copper in reducing the microbial burden (MB) of objects in rooms of intensive care unit (ICU) patients. Poster 183, 5th Decennial Inter-national Conference on Healthcare-Associated Infections, Atlanta, March 29, 2010

19. Prado V., Durán C., Crestto M., Gutierrez A., Sapiain P., Flores G., et al. Tardito C., Schmidt M.: Effec-tiveness of Copper Contact Surfaces in Reducing the Microbial Burden (MB) in the Intensive Care Unit (ICU) of Hospital del Cobre, Calama, Chile. Poster 56.044, pre-sented at the 14th International Conference on Infectious Diseases, Miami, March 11, 2010

20. Hirsch B.E., Attaway H., Nadan R., Fairey S., Hardy J., Miller G., Rai S., ArmellinoD., Schilling M., Moran W., Sharpe P., Estelle A., Michel J.H., Michels H.T., Schmidt M.G.: Copper Surfaces Reduce Microbial Burden in Out-Patient Infectious Disease Practice. Poster presented at the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) in Boston, MA, September 13 2010

21. EPA: National Primary Drinking Water Regulation: Long-Term 2 Enhanced Surface Water Treatment Rule. Fed. Reg. 71: 653 (2006)

22. Agency for Toxic Substances and Disease Registry, ToxFAQs™ for Silver, July 1999. In: http//www.atsdr.cdc.gov/toxfaqs/tf.asp?id=538&tid=97

23. Tierno P.M. (ed.): Τhe secret life of germs: what they are, why we need them, and how we can protect ourselves against them. Atria Books, New York, 2004

24. Committee for the Responsible Use of Silver in Health, Silver efficacy. 2009, In: http//www.silverfacts.com/efficacy.html

25. Pedahzur R., Katzenelson D., Barnea N., Lev O., Shu-val H., Ulitzur S.: The efficacy of long-lasting residual drinking water   disinfectants based on hydrogen peroxide and silver. Water Sci. Technol. 42: 293-298 (2000)

26. Butkus M.A., Labare M.P., Starke J.A., Moon K., Talbot M.:  Use of aqueous silver to enhance inactivation of coli phage MS-2 by UV disinfection. Appl. Environ. Microbiol. 70: 2848-2853 (2004)

27. World Health Organization: Guidelines for Drinking-Water Quality, 2nd Ed. WHO, Geneva, Switzerland, 1996

28. Russell A.D., Hugo W.B.: Antimicrobial activity and action of silver. Prog. Med. Chem. 31: 351–370 (1994)

29. Water Quality Association: Use/Purchase of Home Water Treatment Systems. National Consumer Water Quality Survey, Naperville, IL, 2001

30. Beer C.W., Guilmartin L.E., McLoughlin T.F., White T.J.: Swimming pool disinfection. J. Environ. Health 61: 9-13 (1999)

31. Singer M.: The role of antimicrobial agents in swimming pools. Int. Biodeterior. 26: 159-168 (1990)

32. Albright L.J., Wentworth W., Wilson E.M.: Technique for measuring metallic salt effects upon the indigenous hetero-trophic micro flora of a natural water. Water Res. 6: 1589-1596 (1972)

33. Martinez S.S., Alvarez A.G., Esteban M.: Electrolytically generated silver and copper ions to treat cooling water: an environmentally friendly novel alternative. Int. J. Hydrogen Energy 29: 921-932 (2004)

34. Kim J., Cho M., Oh B., Choi S., Yoon J.: Control of bac-terial growth in water using synthesized inorganic disinfectant. Chemosphere 55: 775-780 (2004)

35. Kim H., Shim J., Lee S.: Formation of disinfection by-products in chlorinated swimming pool water. Chemo-sphere 46: 123-130 (2002)

36. Stout J.E., Yu V.L.: Legionellosis. N. Engl. J. Med. 337: 682-687 (1997)

37. Stout J.E., Yu V.L.: Experiences of the first 16 hospitals using copper-silver ionization for Legionella control: impli-cations for the evaluation of other disinfection modalities. Infect. Control Hosp. Epidemiol. 24: 563-568 (2003)

38. P. Tzitzis, K. Kalousis, M. Myronidou-Tzouveleki: The historical use of botulinum toxin: From biological warfare in treating diseases. Epitheor. Klin. Farmakol. Farmakokinet. Greek Ed.  31: 55-65 (2013)

38. Foegeding P.M., Busta F.F.: Chemical food pre-servatives. In: (Block S.S., ed.), Disinfection, Sterilization and Preservation. 4th Edn, pp. 802-832, Lea and Febiger, Philadelphia, 1991

39. Silver S.: Bacterial silver resistance: molecular biology and uses and misuses of silver compounds. FEMS Mi-crobiol. Rev.  27: 341-353 (2003)

40. Spacciapoli P., Buxton D., Rothstein D., Friden P.: Antimicrobial activity of silver nitrate against periodontal pathogens. J. Periodontal Res. 36: 108-113 (2001)

41. Isenberg S.J.: The dilemma of neonatal ophthalmic prophylaxis. West J. Med. 153: 190-191 (1990)

42. Poon V.K., Burd A.:  In vitro cytotoxity of silver: impli-cation for clinical wound care. Burns 30: 140-147 (2004)

43. Cicalini S., Palmieri F., Petrosillo N.: Clinical review: new technologies for prevention of intravascular catheter-related infections. Crit. Care 8: 157-162 (2004)

44. Gentry H., Cope S.: Using silver to reduce catheter-associated urinary tract infections. Nurs. Stand 19(50): 51–54 (2005)

45. Brady M.J., Lisay C.M., Yurkovetskiy A.V., Sawan S.P.: Persistent silver disinfectant for the environmental control of pathogenic bacteria. Am. J. Infect. Control 31: 208-214 (2003)

46. Quintavalla S., Vicini L.: Antimicrobial food packaging in meat industry. Meat Sci. 62: 373-380 (2002)

47. Bright K.R., Gerba C.P., Rusin P.A.: Rapid reduction of Staphylococcus aureus populations on stainless steel surfaces by zeolite ceramic coatings containing silver and zinc ions. J. Hosp. Infect. 52: 307-309 (2002)

48. Silvestry-Rodriguez N., Sicairos-Ruelas K.E.E., Gerba C.P., K.R. Bright K.R.: Silver as a disinfectant. Rev. Environ. Contam. Toxicol. 191: 23-45 (2007)

49. Committee for the Responsible Use of Silver in Health, Silver efficacy: 2009. In: http//www.silverfacts.com/efficacy.html

50. Yahya M.T., Landeen L.K., Messina M.C., Kutz S.M., Schulze R., Gerba C.P.: Disinfection of bacteria in water systems by using electrolytically generated copper: silver and reduced levels of free chlorine. Can. J. Microbiol. 36: 109-116 (1990)

51. Agency for Toxic Substances and Disease Registry, ToxFAQs™ for Silver, July 1999 In: http//www.atsdr.cdc.gov/toxfaqs/tf.asp?id=538&tid=97

52. World Health Organization: Guidelines for Drinking-Water Quality, 2nd Ed. WHO, Geneva, Switzerland, 1996

53. HVAC Considerations for Gaseous Decontamination of Laboratory Spaces using Hydrogen Peroxide Vapor (HPV)”. Phoenix Controls Corporation. September 2008

53. EPA: Pesticides – Vaporized Hydrogen Peroxide”. US Environmental Protection Agency. September 2008

54. Passaretti C.L., Otter J.A., Lipsett P., Shangraw A., Myers J., Ross T., Carroll K., Perl T.M.: Adherence to Hy-drogen Peroxide Vapor (HPV) decontamination reduces VRE acquisition in high-risk units. 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) and the Infectious Diseases Society of America (IDSA). Washington DC, USA, 2008. Abstract K4124b.

55. Manian F.A., Griesenauer S., Senkel D.: Impact of an intensive terminal cleaning and disinfection (C/D) protocol involving selected hospital rooms on endemic nosocomial infection (NI) rates of common pathogens at a tertiary care medical center. In: Program and Abstracts of the 5th Decennial Meeting of the Society for Healthcare Epidemiology of America (SHEA). Arlington, VA: SHEA 2010. Abstract No LB6.

56. Krause J., McDonnell G., Riedesel H.: Biodeconta-mination of animal rooms and heat sensitive equipment with vaporized hydrogen peroxide. Contemp. Top. Lab. Anim. Sci. 40(6): 18-21 (2001)

57. Rutala W.A., Weber D.J.: Creutzfeldt-Jakob disease: recommendations for disinfection and sterilization. Clin. Infect. Dis. 32: 1348-1356 (2001)

58. Melville N.A.: HP Vapor More Effective Than UVC Light for Decontamination. European Congress of Clinical Micro-biology and Infectious Diseases 21st (ECCMID). Abstract 0141, Presented May 8, 2011

59. Berrie L., Andrews S., Yezli J.A., Otter J.A.: Hydrogen peroxide vapour (HPV) inactivation of adenovirus. Lett. Appl. Microbiol. 52: 555-558 (2011)

60. Hall L., Otter J.A., Chewins J., Wengenack N.L.: Use of hydrogen peroxide vapour for deactivation of Mycobac-terium tuberculosis in a biological safety cabinet and a room. J. Clin. Microbiol. 45: 810-815 (2007)

61. http://www.osha.gov/SLTC/healthguidelines/hydrogenperoxide/recognition.html

62. Καθορισμός οριακών τιμών έκθεσης: Π.Δ 90, ΦΕΚ 94, 13.5.99

63. Advanced Sterilization Products 510(k): Summary of safety and effectiveness, EvoTech System. Irvine, CA: Au-thor. (2005)

64. Akamatsu T., Minemoto M., Uyeda M.: Evaluation of the antimicrobial activity and materials compatibility of orthophthalaldehyde as a high-level disinfectant. J. Int. Med. Res. 33: 178-187 (2005)

65. O’Neil M.J. (Ed.): o-Phthalaldehyde. Pp. 1269-1270, The Merck Index, 14thed. Merck and Co., Inc., Whitehouse Station, NJ, 2006

66. Rideout K.L.: Evaluating occupational health risks as-sociated with substitution of high-level disinfectants in hospital (Τhesis). (2003).

67. Rutala W.A., Weber D.J.: New disinfection and ste-rilization methods. Emerg. Infect. Dis. 7: 348-353 (2001)

68. Hession S.M.: Endoscope disinfection by ortho-pthal-adehyde in a clinical setting: an evaluation of reprocessing time and costs compared with Glutaraldehyde. Gastro-enterol. Nurs. 26: 110-114 (2003)

69. Cabrera-Martinez R.M., Setlow B., Setlow P.: Studies on the mechanisms of the sporicidal action of ortho-phthalaldehyde. J. Appl. Microbiol. 92: 675-680 (2002)

70. National toxicity program, (2007)

71. Cajthaml T., Erbanová P., Sasek V., Moeder M.: Breakdown products on metabolic pathway of degradation of benz[a]anthracene by a ligninolytic fungus. Chemo-sphere 64: 560-564 (2006).

72. Cathy Falliers, 2006. In: www. hopkinsmedicine.org/hse/forms/cidexopa/OPAInstruction.pdf

73. Joint excert comitee. on food additives, 2003.

74. Kuznesof P.M: Sodium Dichloroisocyanurate (NaDCC – anhydrous and dihydrate): Chemical and Technical Asses-sment (CTA), © FAO 2004

75. Mazzola P.G., Vessoni Penna T.-C., Da S. Martins A.M.: Determination of decimal reduction time (D value) of chemical agents used in hospitals for disinfection purposes. BMC Infect. Dis. 3: 24 (2003)

76. McDonnell G., Russell A.D.: Antiseptics and Disin-fectants: Activity, Action, and Resistance. Clin. Microbiol. Rev. 12: 147-179 (1999)

77. Janácek K., Lodin Z.: Determination of chlorine levels in Presept®, a modern disinfectant. Epidemiol. Microbiol. Immunol. 48(2): 63-66 (1999)

78. CRC: Emergency Relief Items Catalogue 2002, Chlorine NaDCC, 2002, In: http//www.redcross.int/en/eric/eric/screen tome 1/09WATscreen/379DASDCHLA0005T.pdf

79. Steris corporation, Annual report, 2010. In: http://www.steris.com/about/ir/releases.cfm

80. STERIS System 1E (SS1E) Liquid Chemical Sterilant – K090036, April,5,2010: Clearance Letter and 510(k) Summary with Indications for Use. In: http://www.accessdata.fda.gov/cdrh_docs/pdf9/K090036.pdf

81. EPA: National Primary Drinking Water Regulation. Long-Term 2 Enhanced Surface Water Treatment Rule. Fed. Reg., 71(2): 653 (2006)

82. Department of Health and Human Services Public Health Services Food and Drug Administration Pharma-cology/Toxicology Review Product: Octaplas LG™, pooled (human) plasma, solvent detergent treated Date received: December 22, 2011 (Pharm/Toxicology, MODULE 4) In: http//: www.steris.com/documents.cfm?id=4000

83. WHO: IARC Monographs on the Evaluation of Car-cinogenic Risks to Humans: Occupational exposures to mists and vapours from sulfuric acid and other strong inorganic acids. Summary of Data Reported and EvaluationVolume 54, 11 November 1997. In: http://monographs.iarc.fr/ENG/Monographs/vol54/volume54.pdf

84. Australian Pesticides & Veterinary Medicines Authority: The Reconsideration of Approvals and Registrations Relating to Polihexanide Polihexanide: Review Scope Document JULY In: http:// ww.apvma.gov.au/products/review/docs/polihexanide_scope.pdf

85. Polyhexamethylene Biguanide (PHMB) Product Stewardship. Summary April 2008, In: http://www.archchemicals.com/Fed/Corporate/Docs/ACC/ARCH_CHEMICALS-PHMB.pdf.

86. Allen M.J., White G.F., Morby A.P.: The response of Escherichia coli to exposure to the biocide polyhexamethy-lene biguanide. Microbiology 152: 989-1000 (2006)

87. Hübner N.O., Matthes R., Koban I., Rändler C., Müller G., Bender C., Kindel E., Kocher T., Kramer A.: Efficacy of chlorhexidine, polihexanide and tissue-tolerable plasma against Pseudomonas aeruginosa biofilms grown on polystyrene and silicone materials. Skin Pharmacol. Physiol. 23(Suppl.): 28-34 (2010)

88. Kusnetsov J.M., Tulkki A.I., Ahonen H.E., Martikainen P.J.: Efficacy of three prevention strategies against legio-nella in cooling water systems. J. Appl. Microbiol. 82: 763-768 (1997)

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