Τίτλος – Title
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Eπίδραση της Παρεκοξίμπης στην Επούλωση των Καταγμάτων στους Επίμυες Short term effects of parecoxib on fracture healing in rats |
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Συγγραφέας – Author
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Παναγιώτης Ακριτόπουλος1,2, Παρασκευή Παπαϊωαννίδου1, Ιπποκράτης Χατζώκος2, Αφροδίτη Χαριτάντη3, Ειρήνη Ιωσηφίδου2, Μαρία Κωτούλα1, Βασιλική Μήρτσου1 1Εργαστήριο Φαρμακολογίας, 2Α΄ Ορθοπαιδική Κλινική, 3Εργαστήριο Ακτινολογίας, Ιατρική Σχολή, Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης, Θεσσαλονίκη Panagiotis Akritopoulos1, Paraskevi Papaioannidou1, Ippokratis Hatzokos2, Αfrodite Haritanti3, Eirine Iosifidou2, Maria Kotoula1, Vasiliki Mirtsou-Fidani1 1Department of Pharmacology, 2ST Department of Orthopedics, 3Department of Radiology, Faculty of Medicine, Aristotle University, Thessaloniki, Hellas |
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Παραπομπή – Citation
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Ακριτόπουλος,Π., Παπαϊωαννίδου,Π., Χατζώκος,Ι., Χαριτάντη,Α., Ιωσηφίδου,Ε.,
Κωτούλα,Μ., Μήρτσου,Β. : Eπίδραση της Παρεκοξίμπης στην Επούλωση των Καταγμάτων στους Επίμυες, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 27: 12-14 (2009)
Akritopoulos,P., Papaioannidou,P., Hatzokos,I., Haritanti,A., Iosifidou,E.
Kotoula,M., Mirtsou-Fidani,V. : Short term effects of parecoxib on fracture healing in rats, Epitheorese Klin. Farmakol. Farmakokinet. 27: 12-14 (2009)
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Ημερομηνία Δημοσιευσης – Publication Date
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8 Μαρτίου 2009 – 2009-03-08
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Γλώσσα Πλήρους Κειμένου –
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Ελληνικά – Greek |
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Λέξεις κλειδιά – Keywords
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Parecoxib, COX-2 inhibitors, COX inhibitors, fracture healing, prostaglandins
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Λοιποί Όροι – Other Terms
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Άρθρο Article |
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Περίληψη – Summary
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– Cyclo-oxygenase inhibitors impair fracture healing by inhibiting prostaglandin synthesis, angiogenesis and bone formation. The purpose of this study was to evaluate the short term effects of parecoxib on fracture healing in Albino Wistar rats, when it is applied for one week immediately after fracture. Closed non-displaced mid-diaphyseal fractures of the left femoral shaft were generated in each animal. In the study group, parecoxib sodium (1.06 mg/kg) was administered intraperitoneally every day for one week. In the control group, normal saline was administered intraperitoneally every day for one week. In both groups fracture healing was evaluated by X-rays 14 days after surgery. Bone healing was lower in the study group (10% vs 30% in the control group) 14 days after fracture but the difference was not statistically significant (p >0.05). Parecoxib delays early fracture healing in rats when it is administered for one week after bone fracture but this effect is not statistically significant. |
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Αναφορές – References
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