Τόμος 27 (2009) – Τεύχος 1 – Άρθρο 15 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 27 (2009) – Issue 1– Article 15 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Από | | Ελευθερία Λειβαδάρου - Eleftheria Livadarou, Ιορδάνης Μουρούζης,Iordanis Mourouzis, Κωνσταντίνος Πάντος,Constantinos Pantos, Νικόλαος Δρακούλης - Nikolaos Drakoulis, Νικόλαος Τσιναράκης,Nikolaos Tsinarakis, Πλήρες Κείμενο στα Ελληνικά - Full Text in Greek, Στατιστική μελέτη - Statistical study
Τίτλος – Title

Μελέτη της Σχέσης μεταξύ των Επιπέδων Θυρεοειδικής Ορμόνης στο Αίμα και των Δεικτών της Καρδιοαναπνευστικής Δοκιμασίας Κόπωσης σε Ασθενείς με Καρδιακή Ανεπάρκεια

Study on the Relation of Thyroid Hormone Plasma Levels and Cardiopulmonary Exercise Testing Indexes in Patients with Heart Failure
Συγγραφέας – Author

Ελευθερία Λειβαδάρου1, Νικόλαος Δρακούλης1, Νικόλαος Τσιναράκης1, Ιορδάνης Μουρούζης2, Κωνσταντίνος Πάντος2

1Τομέας Φαρμακευτικής Τεχνολογίας, Τμήμα Φαρμακευτικής, 2 Εργαστήριο Πειραματικής Φαρμακολογίας, Ιατρική Σχολή, Πανεπιστήμιο Αθηνών, Αθήνα

Eleftheria Leivadarou1, Nikolaos Drakoulis1, Nikolaos Tsinarakis1, Iordanis Mourouzis2, Constantinos Pantos2

1School of Pharmacy, University of Athens, Athens, Greece, 2Department of Pharmacology, University of Athens, 75 Mikras Asias Avenue, 11527 Goudi, Athens, Hellas
Παραπομπή – Citation
 Λειβαδάρου,Ε., Δρακούλης,Ν., Τσιναράκης,Ν., Μουρούζης,Ι., Πάντος,Κ. : Μελέτη της Σχέσης μεταξύ των Επιπέδων Θυρεοειδικής Ορμόνης στο Αίμα και των Δεικτών της Καρδιοαναπνευστικής Δοκιμασίας Κόπωσης σε Ασθενείς με Καρδιακή Ανεπάρκεια, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 27: 48-52 (2009)

Leivadarou,E., Drakoulis,N., Tsinarakis,N., Mourouzis,I., Pantos,C. : Study on the Relation of Thyroid Hormone Plasma Levels and Cardiopulmonary Exercise Testing Indexes in Patients with Heart Failure, Epitheorese Klin. Farmakol. Farmakokinet. 27: 48-52 (2009)
Ημερομηνία Δημοσιευσης – Publication Date
8 Μαρτίου 2009 – 2009-03-08
Γλώσσα Πλήρους Κειμένου –
Full Text Language

Ελληνικά – Greek
Παραγγελία – Αγορά –
Order – Buy
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Digital Type: pdf (15 €)
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Λέξεις κλειδιά – Keywords
–
Thyroid hormone, heart failure, cardiopulmonary exercise testing, peak oxygen consumption
Λοιποί Όροι – Other Terms

Στατιστική Μελέτη

Statistical Study
Περίληψη – Summary

–

Previous experimental studies have provided evidence showing that changes in thyroid hormone signaling correspond to alterations in myocardial function in animal models of heart failure. The present study further explores whether thyroid hormone alterations are correlated with the functional status of the myocardium in patients with heart failure. The present study included 37 patients with dilated cardiomyopathy. The thyroid profile including T3, T4 and TSH measurements was studied in all patients who were also subjected to cardiopulmonary exercise testing, to evaluate their exercise capacity by measuring peak oxygen consumption (VO2max). Continuous variables (T3, T4 and TSH) were entered to the multiple linear logistic regression model using a stepwise method to identify potential independent determinants of VO2max. A strong correlation between total Τ3 and the peak oxygen consumption was observed (r=0,78, p=2×10-8) and the variability in VO2max could be explained in almost 61% of cases by changes in Τ3 values. Furthermore, multivariate analysis showed that total Τ3 was the strongest independent determinant of VO2max. The present study provides additional evidence on the important role of total Τ3 on the cardio-respiratory testing response in patients with heart failure. In conclusion, changes in thyroid hormone levels appear to be closely correlated to myocardial functional status in patients with heart failure. This finding is in aggreement with experimental observations that strongly support a potential role of thyroid hormone in the pathophysiology of heart failure.
Αναφορές – References
 1. Klein I., Ojamaa K.: Thyroid hormone and the cardiovascular system. N. Engl. J. Med. 344: 501-509 (2001)

2. Pantos C., Malliopoulou V., Varonos D.D., Cokkinos D.V.: Thyroid hormone and phenotypes of cardioprotection. Bas. Res. Cardiol. 99: 101-120 (2004)

3. Ascheim D.D., Hryniewicz K.: Thyroid hormone metabolism in patients with congestive heart failure: The low triiodothyronine state. Thyroid 12: 511-515 (2002)

4. Pingitore A., Landi P., Taddei M.C., Ripoli A., L’Abbate A., Iervasi G.: Triiodothyronine levels for risk stratification of patients with chronic heart failure. Am. J. Med. 118: 132-136 (2005)

5. Schmidt-Ott U.M., Ascheim D.D.: Thyroid hormone and heart failure. Curr. Heart Failure Rep. 3: 114-119 (2006)

6. Cohn J.N., Johnson G.R., Shabetai R., Loeb H., Tristani F., Rector T., Smith R., Fletcher R.: Ejection fraction, peak exercise oxygen consumption, cardiothoracic ratio, ventricular arrhythmias, and plasma norepinephrine as determinants of prognosis in heart failure. The V-HeFT VA Cooperative Studies Group. Circulation 87: VI5-VI16 (1993)

7. O’Neill JO, Young JB, Pothier CE & Lauer MS. Peak oxygen consumption as a predictor of death in patients with heart failure receiving beta-blockers. Circulation 2005 111 2313-2318.

8. Belke D.D., Gloss B., Swanson E.A., Dillmann W.H.: Adenoassociated virus-mediated expression of thyroid hormone receptor isoforms a1 and b1 improves contractile function in pressure overload-induced cardiac hypertrophy. Endocrinology 148: 2870-2877 (2007)

9. Kinugawa K., Yonekura K., Ribeiro R.C., Eto Y., Aoyagi T., Baxter J.D., Camacho S.A., Bristow M.R., Long C.S., Simpson P.C.: Regulation of thyroid hormone receptor isoforms in physiological and pathological cardiac hypertrophy. Circulation Res. 89: 591-598 (2001)

10. Pantos C., Mourouzis I., Saranteas T., Paizis I., Xinaris C., Malliopoulou V., Cokkinos D.V.: Thyroid hormone receptors a1 and b1 are downregulated in the post-infarcted rat heart: consequences on the response to ischaemia-reperfusion. Bas. Res. Cardiol. 100: 422-432 (2005)

11. Pantos C., Mourouzis I., Xinaris C., Kokkinos A.D., Markakis K., Dimopoulos A., Panagiotou M., Saranteas T., Kostopanagiotou G., Cokkinos D.V.: Time-dependent changes in the expression of thyroid hormone receptor a1 in the myocardium after acute myocardial infarction: possible implications in cardiac remodelling. Eur. J. Endocrinol. 156: 415-424 (2007)

12. Weber K.T., Kinasewitz G.T., Janicki J.S., Fishman A.P.: Oxygen utilization and ventilation during exercise in patients with chronic cardiac failure. Circulation 65: 1213-1223 (1982)

13. Mancini D.M., Eisen H., Kussmaul W., Mull R., Edmunds L.H.,Jr, Wilson J.R.: Value of peak exercise oxygen consumption for optimal timing of cardiac transplantation in ambulatory patients with heart failure. Circulation 83: 778-786 (1991)

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