Τόμος 3 (1985) – Τεύχος 3 – Άρθρο 6 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 3 (1985) – Issue 3 – Article 6 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Glycopeptide Antitumour Antibiotics

S. M. PIPERAKIS

^{Τμήμα Βιολογίας, Κέντρο Πυρηνικών Ερευνών “Δημόκριτος”}

3: 122-129 (1985)

PHARMAKON-Press: Epitheorese Klin. Farmakol. Farmakokinet.

3: 122-129 (1985)

Glycopeptide Antitumour Antibiotics

In this review the glycope­ptide antitumour antibiotics are discussed in detail. This group of antibiotics includes, bleo­mycin, phleomycin, zorbamycin, victomycin, pla­tomycin and tallysomycin. The present paper deals with the following: (1) The effects of the glycopeptide antitumour antibiotics on proca­ryotes and eucaryotes. (2) The reactors condi­tions. (3) The effects on DNA-dependent DNA polymerases, DNA-dependent RNA polymera­ses, RNA-dependent DNA polymerases and DNA ligase. (4) The effects on deoxyribonu­cleases, ribonucleases. (5) The effect on DNA, RNA, nucleic acid metabolism and chromoso­mes. (6) Finally the medical implication of the antibiotics with or without combinations with other antitumour agents (f.e. radiation, hyper­thermia, chemical compounds etc.).

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