Τόμος 6 (1988) – Τεύχος 2 – Άρθρο 3 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 6 (1988) – Issue 2 – Article 3 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

6: 106-113 (1988)

PHARMAKON-Press: Epitheorese Klin. Farmakol. Farmakokinet.

6: 106-113 (1988)

Progesterone (P) and its derivatives (natural or synthetic) may exercise androgenic-synandrogenic or antian­drogenic-effects in the cellular level accor­ding to their dosage, position, kinetic constant (Km), transportation and metabo­lism. P acts in two levels in the androgen-dependent cell: a) it exercises competitive inhibition of 5a-reduction of testosterone to DHT, and b) it is bound to androgenic receptors. With regard to the synthetic progestins, which recently have been used in therapeutics, mainly as antiandrogens, they seem not to be existing purely as androgenic or antiandrogenic and their effects are dependent on factors which are already mentioned above, between them dosage is the main factor.

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