Τόμος 8 (1990) – Τεύχος 2 – Άρθρο 5 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 8 (1990) – Issue 2 – Article 5 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

8: 113-116 (1990)

PHARMAKON-Press: Epitheorese Klin. Farmakol. Farmakokinet.

8: 113-116 (1990)

The case under presentation concerns a 70 years old patient who was under an amiodarone treatment for 6 months, receiving 200 mg of the drug daily. An infiltration of the lower lobe of the right lung that occured at the fourth month of the treatment without any clinical symptom was diagnosed after a chest x-ray examination. Α steroid therapy was started after amiodarones withdrawal. Two months later, the pulmonary infiltration was vanished. Amiodarone causes such pulmonary side effects and the frequency varies from 2% to 15%. Periodic chest x-rays and clinical evaluation must be performed in patients who are under a long treatment with this substance. Evidence of toxicity requires withdrawal of the drug in order to establish reversibility.

1. Bigger, Τ., Hoffman, B.: Antiarrhythmic drug. In: Good­man and Gilman’s: The Pharmacological Basis of The­rapeutics, p. 748, MacMillan Publishing Company, 1985
2. Hondeghem, L., Mason, J.: Agents used in cardiac arrhythmias. In: Basic and Clinical Pharmacology (B. Katzung, ed.), p. 158, Lange Medical Publications, Los Altos, 1984
3. Α. Παραδέλλης: Αλληλεπιδράσεις Φαρμάκων. University Press, Θεσσαλονlκη, 1985
4. B. Olin (ed.): Drug, Facts and Comparisons. p. 526, J.B. Lippincott Company, Saint Louis, 1988
5. L. Opie (ed.): Drugs for the Heart. Grune and Stratton Inc., New York, 1988