Τόμος 9 (1991) – Τεύχος 4 – Άρθρο 3 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 9 (1991) – Issue 4 – Article 3 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

9: 224-233 (1991)

PHARMAKON-Press: Epitheorese Klin. Farmakol. Farmakokinet.

9: 224-233 (1991)

Oncogenes, mutagenesis, cancer

The present review summarizes the current knowledge concerning the ras oncogenes. Ras oncogenes are respon­sible for induction of cancer in animals and have been identified in a large number of human malignancies, as well. We describe the common mechanisms by which they are activa­ted and, also, the methods — biological or direct assays — that allow their identification. Finally, we mention the more common ma­lignancies, where activated ras oncogenes are found in a large proportion, as well as several other parameters that can modulate the ap­pearance of cancer.

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