Τόμος 10 (1992) – Τεύχος 1 – Άρθρο 4 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 10 (1992) – Issue 1 – Article 4 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

10: 58-61 (1992)

PHARMAKON-Press: Epitheorese Klin. Farmakol. Farmakokinet.

10: 58-61 (1992)

DNA repair mechanisms, mammalian cells, hierarchies in the repair

When mammalian cells are exposed to various agents which cause dama­ge to DNA, the repair which takes place in the different parts of the genome is heteroge­neous. It is believed that pyrimidine dimers are repaired in at least three levels: (a) an accele­rated repair of the transcribed strand of trans­criptionally active genes, (b) fast repair of actiνe housekeeping genes and (c) slow repair of inactive genes.

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