Τόμος 10 (1992) – Τεύχος 3 – Άρθρο 6 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 10 (1992) – Issue 3 – Article 6 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

10: 164-172 (1992)

PHARMAKON-Press: Epitheorese Klin. Farmakol. Farmakokinet.

10: 164-172 (1992)

Arrhythmias, myocardial ischaemia, mechanisms

Various metabolic disturbances, which take place during ischaemia, are directly related to the appearance of ventricular arrhythmias. Such metabolic disturbances are: (a) The surplus of potassium in the extracellular space; (b) The release of catecholamines; c) The rise of tissue CAMP values; (d) The accumulation of long chain acylcarnitine and the lysophosphati­dylcholine. The underlying mechanisms for those arrhythmias, due to the above metabolic disturb­ances, are the abnormal automaticity, the intra­myocardial conduction defect, the appearance of late potentials and the re-entry, in general.

1. Hill JL, Gettes LS: Effect of acute coronary artery occlusion on local myocardial extracellular K⁺ activity in swine. Circulation 61: 768-778 (1980).
2. Watanabe I, Johnson ΤΑ, Buchanan J et al: Effect of graded coronary flow reduction on ionic, electrical and mechanical indexes of ischemia in the pig. Circulation, 76: 1127-1134 (1987).
3. Crake T, Kirby MS, Poole-Wilson P: Potassium efflux from the myocardium during hypoxia: role of lactate ions. Cardiovasc. Res., 21: 886-891 (1987).
4. Noma A: ATP-regulated K⁺ channels in cardiac muscle. Nature, 305: 147-148 (1980).
5. Noma A, Shibasaki T: Membrane current through adenosine-triphosphate-regulated potassium channels in guinea-pig ventricular cells. J. Ρhysiol., 363: 63-480 (1985)