Τίτλος – Title
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Στατίνες και Γυναικομαστία Gynaecomastia and Statins |
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Συγγραφέας – Author
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Ευγενία Γιαννακοπούλου Σχολή Επαγγελμάτων Υγείας και Πρόνοιας, Tεχνολογικό Εκπαιδευτικό Ίδρυμα Αθηνών ΑΤΕΙ Αθηνών, Αιγάλεω, Αθήνα, Ελλάς Evgenia Yiannakopoulou Faculty of Health and Caring Profesions Technological Educational Institute of Athens, Athens Hellas |
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Παραπομπή – Citation
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Γιαννακοπούλου,Γ. : Στατίνες και Γυναικομαστία, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 27: 19-22 (2009)
Yiannakopoulou,E. : Gynaecomastia and Statins, Epitheorese Klin. Farmakol. Farmakokinet. 27: 19-22 (2009)
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Ημερομηνία Δημοσιευσης – Publication Date
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8 Μαρτίου 2009 – 2009-03-08
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Γλώσσα Πλήρους Κειμένου –
Full Text Language |
Ελληνικά – Greek |
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Παραγγελία – Αγορά –
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Ηλεκτρονική Μορφή: pdf (15 €) –
Digital Type: pdf (15 €) pharmakonpress[at]pharmakonpress[.]gr |
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Λέξεις κλειδιά – Keywords
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Στατίνες, γυναικομαστία, ανεπιθύμητες ενέργειες, συστηματική ανασκόπηση
Gynaecomastia, statins, adverse drug events, systematic review
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Λοιποί Όροι – Other Terms
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Άρθρο Article |
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Περίληψη – Summary
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– Gynaecomastia is the most common breast disorder in men, often consisting a diagnostic dilemma for clinicians as the differential diagnosis of gynaecomastia from male breast cancer is imperative. Drugs including statins are implicated in 10-25% of cases of gynaecomastia. Drug induced gynaecomastia may be due to an impaired balance of oestrogen-androgen ratio with a direct effect on breast tissiue. A systematic review of available data on statin-induced gynaecomastia was attempted. Case reports and postmarketing pharmacovigilance data were identified for atorvastatin, rosuvastatin, pravastatin, simvastatin, fluvastatin, cerivastatin and lovastatin. Treatment was drug withdrawal and regression of gynaecomastia was noted within a few months. |
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Αναφορές – References
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1. Braunstein J.D.: Clinical practice. Gynaecomastia. N. Engl. J. Med. 357: 1229-1237 (2007)
2. Carlson HE.: Gynaecomastia. N. Engl. J. Med. 303: 795-799 (1980) 3. Gikas P., Mokbel B.: Management of gynaecomastia:an update. Int. J. Clin. Pract. 61: 1209-1215 (2007) 4. Ηands L.J., Greenhall M.J.: Gynaecomastia. Br. J. Surg. 78: 907-911 (1991) 5. Neuman J.F. Evaluation and treatment of gynaecomastia. Am. Fam. Physician 55: 1835-1844 (1997) 6. Cornes P.G.S., Hole H.C.: Breast 10: 544-545 (2001) 7. Echman A., Dobs A.: Drug induced gynaecomastia. Expert Opin. Drug Saf. 7: 691-702 (2008) 8. Huques F.C., Gourlot C., Le Jeunne C.: Drug induced gynaecomastia. Ann. Med. Interne (Paris) 151: 10-17 (2000) 9. Τhompson D.F., Carter J.R.: Drug induced gynaecomastia. Pharmacotherapy 13: 37-45 (1993) 10. Kiortsis D.N., Filippatos T.D., Mikhailidis D.P., Elisaf M.S., Liberopoulos E.N.: Statin associated adverse effects beyond muscle and liver toxicity. Atherosclerosis 195: 7-16 (2007) 11. Niewoehner C., Schorer A.: Gynaecomastia and breast cancer in men. BMJ 336: 709-713 (2008) 12. Yiannakopoulou E., Damianou Ch., Bamia Ch., Papadopoulos J.S.: Αdequacy of safety data reporting in randomized clinical trials comparing coxibs with non selective NSAIDs. Epitheor. Klin. Farmakol. Farmakokinet. 23: 42-43 (2005) 13. Yiannakopoulou E.: Quantification of adverse drug reations-the role of systematic review-meta-analysis. Iatriki 93: 133-142 (2008) 14. Yiannakopoulou E.: Cephalosporin induced haemolytic anaemia in surgical patients:systematic review. Rev. Pharmacol. Pharmacokinet. Intern. Ed. 22: 363-365 (2008) 15. Stein E., Illingworth R., Kwiterovich P.: Efficacy and safety of lovastatin in adolescent males with heterozygous familial hypercholesterolemia. JAMA 281: 137-144 (1999) 16. Black D., Bakker-Arkemma R., Nawrocki J.: An overview of the clinical safety profile of atorvastatin (Lipitor), a new HMG-CoA Reductase Inhibitor. Arch. Intern. Med. 158: 577-584 (1998) 17. Oteri A., Catania M., Travaglini R., Russo A., Giustini S., Caputi A., Polymeni G.: Gynaecomastia possibly induced by rosuvastatin. Pharmacotherapy 28: 549-551 (2008) 18. Αerts J., Karmochkine M., Raguin G.: Gynaecomastia due to pravastatin. Presse Méd. 28: 787 (1999) 19. Hammons K.B., Edwards R.F., Rice W.Y.: Golf inhibiting gynaecomastia associated with atorvastatin treatment. Pharmacotherapy 26: 1165-1168 (2006) 20. Adverse Drug Advisory Committee. Simvastatin and adverse endocrine effects in men. Aust. Adverse Drug React. Bull. 14: 3 (1985) 21. Αnonymous.: Pharmaceutical preparations are usually the cause of gynaecomastia. Lakartindingen 93: 489-490 (1996) 22. Naranjo C.A., Busto U., Sellers E.M., Sandor P., Ruiz I., Roberts E.A., Janecek E., Domeck C., Greenblatt D.J.: A method for estimating the probability of adverse drug reactions. Clin. Pharmacol. Ther. 30: 239-245 (1981) 23. Philpot C., Morlay J.: Health issues unique to the aging man. Geriatr. Nurs. 21: 234-240 (2000) 24. Adverse Drug Advisory Committee. Drug induced gynaecomastia. Aust, Adverse Drug React. Bull. 16: 3 (1997) 25. Carvajal A., Macias D., Gutierriez A., Ortega S., Sainz M., Martin Arias L.H., Velasco A.: Gynaecomastia associated with proton pump inhibitors: a case series from the Spanish Pharmacovigilance System. Drug Saf. 30: 527-531 (2007) 26. Prisant L.M., Chin E.: Gynaecomastia and hyperten-sion. J. Clin. Hypertens. (Greenwich) 7: 245-254 (2005) 27. Μalaga I., Sanmarti F.: Two cases of painful gynaecomastia and lower extremity pain in association with pregabalin therapy. Ιntern. League Epileps. 47: 1576-1579 (2006) 28. Carvajal A., Martin Arias L.H.: Gynaecomastia and sexual disorders after the administration of omeprazole. Am. J. Gastroenterol. 90: 1028-1029 (1995) 29. Gardette V., Vezzoci D., Maiza G.C., Montastruc J.L., Olivier P.: Gynaecomastia associated with fenofibrate. Ann. Pharmacother. 41: 508-511 (2007) |
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