Τόμος 27 (2009) – Τεύχος 1 – Άρθρο 6 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 27 (2009) – Issue 1– Article 6 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Τίτλος – Title

Στατίνες και Γυναικομαστία

Gynaecomastia and Statins

Συγγραφέας – Author

Ευγενία Γιαννακοπούλου

Σχολή Επαγγελμάτων Υγείας και Πρόνοιας, Tεχνολογικό Εκπαιδευτικό Ίδρυμα Αθηνών ΑΤΕΙ Αθηνών, Αιγάλεω, Αθήνα, Ελλάς

Evgenia Yiannakopoulou

Faculty of Health and Caring Profesions Technological Educational Institute of Athens, Athens Hellas

Παραπομπή – Citation
Γιαννακοπούλου,Γ. : Στατίνες και Γυναικομαστία, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 27: 19-22 (2009)

Yiannakopoulou,E. : Gynaecomastia and Statins, Epitheorese Klin. Farmakol. Farmakokinet. 27: 19-22 (2009)
Ημερομηνία Δημοσιευσης – Publication Date
8 Μαρτίου 2009 – 2009-03-08
Γλώσσα Πλήρους Κειμένου –
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Ελληνικά – Greek

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Λέξεις κλειδιά – Keywords
Στατίνες, γυναικομαστία, ανεπιθύμητες ενέργειες, συστηματική ανασκόπηση
Gynaecomastia, statins, adverse drug events, systematic review
Λοιποί Όροι – Other Terms

Άρθρο

Article

Περίληψη – Summary

Gynaecomastia is the most common breast disorder in men, often consisting a diagnostic dilemma for clinicians as the differential diagnosis of gynaecomastia from male breast cancer is imperative. Drugs including statins are implicated in 10-25% of cases of gynaecomastia. Drug induced gynaecomastia may be due to an impaired balance of oestrogen-androgen ratio with a direct effect on breast tissiue. A systematic review of available data on statin-induced gynaecomastia was attempted. Case reports and postmarketing pharmacovigilance data were identified for atorvastatin, rosuvastatin, pravastatin, simvastatin, fluvastatin, cerivastatin and lovastatin. Treatment was drug withdrawal and regression of gynaecomastia was noted within a few months.

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