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Τίτλος – Title
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α2 Αδρενεργικοί Αγωνιστές και Ραχιαία Αναισθησία: Ο Ρόλος της Κλονιδίνης α2 Αdrenergic Agonists and Spinal Anaesthesia: The Role of Clonidine |
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Συγγραφέας – Author
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Δημήτριος Επιτρόπου, Μαρία Μυρωνίδου-Τζουβελέκη Α΄ Εργαστήριο Φαρμακολογίας, Ιατρική Σχολή, Αριστοτέλειο Πανεπιστήμιο, Θεσσαλονίκη, Ελλάς Dimitrios Epitropou, Maria Mironidou-Tzouveleki 1st Department of Pharmacology, Medical School,Aristotle University, Thessaloniki , Hellas |
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Παραπομπή – Citation
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Επιτρόπου,Δ., Μυρωνίδου-Τζουβελέκη,Μ. : α2 Αδρενεργικοί Αγωνιστές και Ραχιαία Αναισθησία: Ο Ρόλος της Κλονιδίνης, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 27: 30-32 (2009)
Epitropou,D., Mironidou-Tzouveleki,M. : α2 Αdrenergic Agonists and Spinal Anaesthesia: The Role of Clonidine, Epitheorese Klin. Farmakol. Farmakokinet. 27: 30-32 (2009)
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Ημερομηνία Δημοσιευσης – Publication Date
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8 Μαρτίου 2009 – 2009-03-08
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Γλώσσα Πλήρους Κειμένου –
Full Text Language |
Ελληνικά – Greek |
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Παραγγελία – Αγορά –
Order – Buy |
Ηλεκτρονική Μορφή: pdf (15 €) –
Digital Type: pdf (15 €) pharmakonpress[at]pharmakonpress[.]gr |
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Λέξεις κλειδιά – Keywords
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Αδρενεργικός υποδοχέας, κλονιδίνη, οπιοειδή, ραχιαία αναισθησία, χρόνιος πόνος
Αdrenergic receptor, clonidine, opioids, spinal anaesthesia, chronic pain
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Λοιποί Όροι – Other Terms
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Άρθρο Article |
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Περίληψη – Summary
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– α2 Αdrenergic agonists can be used with anaesthetic agents to modulate pain perception. The administration of clonidine epidurally has also been proposed in patients with chronic pain. The goal of this review is to provide a clinically useful synthesis of published experience with clonidine for spinal anaesthesia, focusing on efficacy when administered alone or in combination with other analgesics in specific patient populations and appropriate monitoring and treatment of side effects. |
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Αναφορές – References
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1. Unnerstall J.R., Kopajtic T.A., Kuhar M.J.: Distribution of α2 agonist binding sites in the rat and human central nervous system: Analysis of some fuctional, anatomic correlates of the pharmacologic effects of clonidine and related adrenergic agents. Brain Res. Rev. 7: 69-101 (1984)
2. Giovannoni M.P., et al.: Alpha2 agonists as analgesic agents. Med. Res. Rev. 4: 1-30 (2008) 3. Kingery W.S., Guo T.Z., Davies M.F., Limbird L., Maze M.: The α2A adrenoreceptor and the sympathetic postganglionic neuron contribute to the development of neuropathic heat hyperalgesia in mice. Pain 85: 345-358 (2000) 4. Ma W., Eisenach JC.: Neuronal nitric oxide synthase is upregulated in a subset of primary sensory afferents after nerve injury which are necessary for analgesia from α2-adrenoreceptor stimulation. Brain Res. 1127: 52-58 (2007) 5. Peck T.E., Williams M.: Pharmacology for Anaesthesia and Intensive Care 2000:235-239. 6, Paalzow L.: Analgesia produced by clonidine in mice and rats. J. Pharmacol. 26: 361-363 (1974) 7. Tryba M., Gehling M.: Clonidine.: A potent analgesic adjuvant. Curr. Opin. Anaesthesiol. 15: 511-517 (2002) 8. Wolff et al.: Clonidine reduces the excitability of spinal dorsal horn neurones. Br. J. Anaesth. 15: 511-517 (2002) 9. Pant K.K., Tangri K.K., Bhargava K.P.: Adrenergic Influences on the spinal cardiovascular Neurones. J. Auton. Pharmac. 3: 241-248 (1983) 10. Nutt J.D., Glue P.: Aspects of alpha-2-adrenoreceptor function in normal volunteers. Hum. Psychopharmacol. 3: 235-245 (1988) 11. Luebbe N., Walz R., Walz K., Kiesel C., Bomscheuer A.: Clonidine prolongs fentanyl-induced ventilatory depresssion. Eur. J. Anaesthesiol. 15: 292-296 (1998) 12. Dobrydnjov I., Axelsson K., Gupta A., Lundin A., Holmström B. Granath B.: Improved analgesia with clonidine when added to local anesthetic during combined spinal-epidural anesthesia for hip arthroplasty: a double blind, randomized and placebo-controlled study. Acta Anaesthesiol. Scand. 49: 538-545 (2005) 13. D΄Angelo et al.: Spinal clonidine prolongs labor analgesia from spinal Sufentanil and Bupivacaine. Anesth. Analg. 88: 573-576 (1999) 14. Watson B., Howell V.: Spinal anaesthesia: The saviour of day surgery? Curr. Anaesth. Crit. Care 18: 193-199 (2007) 15. Martin J.T., Eisenach C.J.: Pharmacology of opioid and nonopioid analgesics in chronic pain states. JPET 299: 811-817 (2001) 16. Brogan SE.: Intrathecal therapy for management of cancer pain. Curr. Pain Headache Rep. 10: 254-259 (2006) |
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Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in:
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• Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE
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Τι είναι η Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση-Οδηγίες προς τους Συγγραφείς
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Άρθρα Δημοσιευμένα στην Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση
Articles Published in Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition
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