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Τίτλος – Title
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Επίδραση της Νιφεδιπίνης στη Στένωση της Νεφρικής Αρτηρίας σε Επίμυες Influence of Nifedipine on Hypertension and Lipid Factors in Rats |
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Συγγραφέας – Author
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Χριστίνα Τεσσερομάτη1, Αντωνία Κώτσιου2 1Εργαστήριο Πειραματικής Φαρμακολογίας Ιατρικής Σχολής Αθηνών, Μ. Ασίας 75, Αθήνα 11527, Ελλάς, Christina Tesseromatis1, Antonia Kotsiou2 1Laboratory of Experimental Pharmacology, Medical School, University of Athens, M. Asias 75, Athens 11527, Hellas |
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Παραπομπή – Citation
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Τεσσερομάτη,X., Κώτσιου,A. : Επίδραση της Νιφεδιπίνης στη Στένωση της Νεφρικής Αρτηρίας σε Επίμυες, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 27: 99-101 (2009)
Tesseromatis,C., Kotsiou,A. : Influence of Nifedipine on Hypertension and Lipid Factors in Rats, Epitheorese Klin. Farmakol. Farmakokinet. 27: 99-101 (2009)
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Ημερομηνία Δημοσιευσης – Publication Date
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8 Μαρτίου 2009 – 2009-03-08
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Γλώσσα Πλήρους Κειμένου –
Full Text Language |
Ελληνικά – Greek |
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Λέξεις κλειδιά – Keywords
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Nifedipine, heart, renal artery experimental ligation
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Λοιποί Όροι – Other Terms
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Κλινική Μελέτη Clinical Trial |
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Περίληψη – Summary
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– Renal artery stenosis of any origin (acute renal occlusion, diabetes mellitus, coronary, atheromatous, thromboembolic disorders) is known as a secondary cause of hypertension. Aim: to investigate the metric and biochemical changes in heart muscle following renal artery ligation and the effect of a calcium channel blocker (nifedipine) treatment. Four groups of 7 Wistar rats aged 5 weeks were used (A and B control, Γ and Δ experimental). The animals of Γ and Δ groups underwent renal artery ligation. Groups Β and Δ were administered nifedipine p.o.. 6 mg/kg for 10 days. Serum total cholesterol, triglycerides, urea, glucose levels were determined. Adrenal and heart weights were measured as well as heart muscle dimensions in order to evaluate heart hypertrophy. It is concluded that nifedipine administration ameliorated the cardiovascular parameters due to hypertension, but had no effect on the blood chemistry. |
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Αναφορές – References
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1. Rai P., Gigliotti O.S., Mathews B., Kurian K.C.: Renal artery stenosis: an update on diagnosis and management. Indian Heart J. 58: 393-400 (2006)
2. Nakamura S., Ishibashi-Ueda H., Suzuki C., Nakata H., Yoshihara F., Nakahama H., Kawano Y.: Renal artery stenosis and renal parenchymal damage in patients with abdominal aortic aneurysm proven by autopsy. Kidney Blood Press Res. 32: 11-16 (2009) 3. Onusko E.: Diagnosing secondary hypertension. Am. Fam. Physician 67: 67-74 (2003) 4. Rousseau D., Héliès-Toussaint C., Raederstorff D., Moreau D., Grynberg A.: Dietary n-3 polyunsaturated fatty acids affect the development of renovascular hypertension in rats. Mol. Cell Biochem. 225: 109-119 (2001) 5. Textor S.C.: Ischemic nephropathy: where are we now? J. Am. Soc. Nephrol. 15: 1974-1982 (2004) 6. Pickering T.G.: Renovascular hypertension: etiology and pathophysiology. Semin. Nucl. Med. 19: 79-88 (1989) 7. Ots Μ., Pechter Ü., Tamm A.: Characteristics of progressive renal disease. Clin. Chim. Acta 297: 29-41 (2000) 8. Gyöngyössi G.: Plasma levels of free fatty acids, triglycerides and cholesterol in acute subrenal kidney failure. Acta Chir. Acad. Sci. Hung. 21: 245-248 (1980) 9. Orbetzova V., Kiprov D., Puchlev A.: The action of arterial hypertension on lipid and lipoprotein metabolism. I. Salt, adrenal-regeneration and renal (Goldblatt) hypertension. Cor. Vasa. 18: 209-220 (1976) 10. Li P., Zhang X., Capasso J.M., Meggs L.G., Sonnenblick E.H., Anversa P.: Myocyte loss and left ventricular failure characterise the long term effects of coronary artery narrowing or renal hypertension in rats. Cardiovasc. Res. 27: 1066-1075 (1993) 11. Wu S., Polavarapu N., Stouffer G.A.: Left ventricular hypertrophy in patients with renal artery stenosis. Am. J. Med Sci. 332: 334-338 (2006) 12. Dubel G.J., Murphy T.P.: The role of percutaneous revascularization for renal artery stenosis. Vasc. Med. 13: 141-156 (2008) 13. Helmchen U., Gröne H.J., Kirchertz E.J., Bader H., Bohle R.M., Kneissler U., Khosla M.C.: Contrasting renal effects of different antihypertensive agents in hypertensive rats with bilaterally constricted renal arteries. Kidney Int. 12(Suppl.): S198-205 (1982) |
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Online ISSN 1011-6575
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