Τόμος 1 (1983) – Τεύχος 2 – Άρθρο 3 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 1 (1983) – Issue 2– Article 3 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Τίτλος – Title Συνοπτική Λειτουργία και Νευρομεταβιβαστές

Synaptic function and neurotransmitters

Συγγραφέας – Author Ζωή Παπαδοπούλου-Νταϊφώτη

Εργαστήριο Πειραματικής Φαρμακολογίας Πανεπιστημίου Αθηνών

Z. Papadopoulou-Daifotis

Dept. of Exp. Pharmacology University of Athens

Παραπομπή – Citation Παπαδοπούλου-Νταϊφώτη, Ζ.: Συνοπτική Λειτουργία και Νευρομεταβιβαστές, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 2: 110-117 (1983)

Papadopoulou-Daifotis, Ζ.: Synaptic function and neurotransmitters, Epitheorese Klin. Farmakol. Farmakokinet. 2: 110-117 (1983)

 

Ημερομηνία Δημοσιευσης – Publication Date Ιούλιος 1983 – July 1983
Γλώσσα Πλήρους Κειμένου –
Full Text Language
Ελληνικά – Greek
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Λέξεις κλειδιά – Keywords Νευρικά κύτταρα,  ΚΝΣ, μετασυναπτική μεβράνη

 

Neuron; Nerve terminal; postsynaptic membrane

Λοιποί Όροι – Other Terms Άρθρο
Article
Περίληψη – Summary Chemical transmission is now accepted as the principal means of communication between a neuron and its target, whether that be another neuron, a muscle or a gland. The process of synaptic transimission involves synthesis and storage of a transmitter substance in the presynaptic terminal, release of that substance into extracellular space and interaction of the transmitter with specific receptors on the postsynaptic membrane that trigger either electrical or biochemical alteration in the postsynaptic cell. Biochemical, ultrastractural and physiological experiments have led to the concept that transmitter molecules are stored within vesicles in the nerve terminal and that the Ca++-dependent excitation secretion coupling within the depolarized nerve terminal requires the transient exchange of vesicular components into the synaptic cleft. In spite of the complexity of the mammalian central nervous system, several generalizations on the mechanisms of synaptic transmission may be made:
1.         Transmitter release results from a Ca++ dependent exocytosis
2.        Any single transmitter may produce different responses at different locations and3.        A particular ionic or biochemical response can be elicited by different transmitters at different locations.
Αναφορές – References 1.         Νίκητοπούλου-ΜαράτοLi, Γ.: φυσιολογία του ανθρώπου. Εκδόσεις Γ.Κ. Παρισιάνος Αθήνα 1983

2.         Bloom, F.E.: Neurohumoral Transmission and the Central Nervous System. In the Pharmacological Basis of Therapeutics, 6th ed. McMillan, New York, p. 235 (1980)

3.         Cooper RJ., Bloom, F., Roth, R.: In the Biochemical Basis of Neuropharmacology. Oxford Univ. Press, New York, p. 13 (1982)

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5.         Δ. Δ. Βαρώνος, Ιατρική φαρμακολογία. Εκδόσεις Γ, Κ. Παρισιάνος, Αθήνα 1976

6.         Bubin, R.P.: The role of calcium in the release of neurotrasmitter substances and hormones. Pharmacol. Rev. 22: 389 (1970)

7.         Mathews, E.K. and O’ Connor, M.D.L.: Dynamic oscillations in the membrane potential of pancreatic islet cells. J. Exp. Biol. 81: 75 (1979)

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9.         Eccles, J.C.: The Physiology of Nerve Cells. Baltimore: Johns Hopkins Press, 1952

10.       Kandel, E. R etal: Direct and common connections among the identified neurons in the abdominal ganglion of Aphysia J. Neurophysiol 30: 1352 (1967)

11.        Eurshpan, EJ. et al: Chemical transmission between rat sympathetic neurons and cardiac myocytes developing in microcultures. Proc. Natl, Acad. Sci. U.SA. 73: 4225 (1976)

12.       Brownstein, M.J. et al: Coexistence of several putative neurotransmitters in single identified neurons of Aphysia. Proc. Natl. Acad. Sci. USA 71: 4662 (1974)

13.       Cottrell, G.A.: Does the giant cerebral neurone of Helix release two transmitters ACH and serotonin? J. Physiol. (London) 259: 44 P (1976)

14.       Roberts, E., and Frankel, S.: y- aminobutyric acid in brain J. Biot. Chem. 187: 55 (1950)

15.       Snyder, S.H.: The glycine synaptic receptor in the mammalian central nervous system. Br. J. Pharmacol. 53: 473 (1975)

16.       Siegel G-, Albers Wayne, Agranoff, B., Katzman, R.: Basic Neurochemistry p. 162, 1981

17.       Leeman, S.E., Mroz, E.A.: Substance P. Life Sci. 15: 2033 (1975)

18.       Bidlack, J.M., Abood, L.G.: Solubilization of the opiate receptor. Life Sci. 27: 331 (1980)

19.       Katz, B.: The release of Neural Transmitter Substance. Liverpool Univ. Press, 1969

20.      Heuser, J.E., Reese T. S.: Structure of Synapse. !n: (E. Kandel. ed) The Handbook of Physiology p. 261, 1977

21.       Dei Castillo, J., Katz, B.: Biochemical aspects of neuromuscular transmission Prog. Biophys. Mol. Biol. 6: 121 (1956)

22.       Kriebel, M.E., Liados, F., Matteson, D.R.: Multimodal distribution of frog miniature end-plate potentials in adult, denervated leg muscle. J. Gen. Physiol. 192: 407

23.       Siegel G. et al: Basic Neurochemistry P. 170, 1981

24.       Couteaux, R, Pecot-Dechavassine, M.: Vésicules synaptiques et poches au niveau des «Zones actives» de la jonction neuromasculaîre. C.R. Acad. Sci. C. Sci. Chem. 271: 2346 (1970)

25.       Gulley, R.L., Landis D.M. and Reese T.S.: Internal organization of membranes at end bulbds of Held in the anteroventrval cochlear mucleus. J. Comp. Neurol. 180: 707 (1978)

26.       Landis, D.M.D., Reese, T.S.: Differences in membrane structure between excitatory and inhibitory components of the reciprocal synapse in the olfactory buld. J. Comp. Neurol. 155: 67 (1974)

27.       Hille, B.: Gating in sodium channels in nerve. Ann. Rev. Physiol. 38: 139 (1976)

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29.       Anderson, P. et al: Iontophoresis and transmitter mechanism in mammalian Central Nervous System. Amsterdam, Elsevier, p. 179, 1978

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