Τόμος 25 (2007) – Τεύχος 1 – Άρθρο 11 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 25 (2007) – Issue 1– Article 11 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Από | | Άρθρο - Article, Μαρία Μυρωνίδου-Τζουβελέκη - Maria Mironidou-Tzouveleki, Πλήρες Κείμενο στα Ελληνικά - Full Text in Greek, Χαράλαμπος Δόκος , Charalampos Dokos
Τίτλος – Title

Η Ανασταλτική Δράση των μη Στεροειδών Αντιφλεγμονωδών Φαρμάκων στην Πώρωση των Καταγμάτων

The Inhibitory Effect of Non-steroidal Anti-inflammatory Drugs in Fracture Healing
Συγγραφέας – Author

Χαράλαμπος Δόκος και Μυρωνίδου-Τζουβελέκη Μαρία

Εργαστήριο Φαρμακολογίας, Ιατρική Σχολή, Αριστοτέλειο Πανεπιστήμιο, Θεσσαλονίκη, Ελλάς

Ch. Dokos and M. Mironidou-Tzouveleki

Laboratory of Pharmacology, Medical School, Aristotle Univesity, Thessaloniki, Greece
Παραπομπή – Citation
Χαράλαμπος,Δ.,  Μυρωνίδου-Τζουβελέκη,Μ.,  : Η Ανασταλτική Δράση των μη Στεροειδών Αντιφλεγμονωδών Φαρμάκων στην Πώρωση των Καταγμάτων, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 25: 38-39 (2007)
Dokos,Ch., Mironidou-Tzouveleki,Μ., : The Inhibitory Effect of Non-steroidal Anti-inflammatory Drugs in Fracture Healing, Epitheorese Klin. Farmakol. Farmakokinet. 25: 38-39 (2007)
Ημερομηνία Δημοσιευσης – Publication Date
2007 – 2007
Γλώσσα Πλήρους Κειμένου –
Full Text Language

Ελληνικά – Greek
Παραγγελία – Αγορά –
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Λέξεις κλειδιά – Keywords
–
Non-steroidal anti-inflammatory drugs, fracture healing
Λοιποί Όροι – Other Terms

Άρθρο

Article
Περίληψη – Summary
–
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely prescribed for their characteristic pharmacological properties: they are good analgesic, an­tipyretic and anti-inflammatory agents. NSAIDs are in­hibitors of cyclo-oxygenase enzyme (COX-1, COX-2 isomorphs) that regulates the production of prostagland­ins from arachidonic acid (phospholipid deriva­tive). Fracture healing is a complex procedure that is induced by topical and non-topical factors regulated by signal transduction pathways. Classical NSAIDs like indo­methacin, ketorolac, diclofenac reduce the pro­duction of new bone tissue in fractures. Experimental models indi­cate that there is poor mineralization of demineralized bone matrix grafts and Harvesian re­modeling. New COX-2 selective inhibitors (coxibs) are still under research for their inhibitory effect in fracture healing. Seeking answers for the complex phenome­non of inhibition of bone heal­ing, transgenic mice (null COX-1 and COX-2) are widely used so as to define the molecular and pharmacological basis. Although NSAIDs are prescribed for their analge­sic and anti-inflammatory effects in fractures, it is best to avoid their use.
Αναφορές – References
 1. Brunton L., Lazo J., Parker K.: Analgesic-antipyretic and anti-inflammatory agents and drugs employed in the treat­ment of gout. In: Goodman and Gillman’s: The Pharmacol­ogical Basis οf Therapeutics. Chapter 27, McGraw-Hill, 2005

2. Katzung G.B. (ed.): Nonsteoidal anti-inflammatory drugs, disease-modifying antirheumatic drugs, nonopioid analgesics and drugs used in gout. Basic and Clinical Pharmacology. Chapter 36, Lange Medical Book, McGraw – Hill, 2004

3. Dandy J.D., Edwards J.D.: Essential Orthopaedics and Trauma. Churchill Livingstone, 2003

4. McRae R.: Pocketbook of Orthopaedics and Fractures. Churchill Livingstone, 2006

5. Seidenberg B.A, An H.Y.: Is there an inhibitory effect of COX-2 inhibitors on bone healing? Pharmacol. Res. 50: 151-156 (2004)

6. Nazon D., Abergel G., Hatem M.C.: Critical care in ortho­pedic and spine surgery. Crit. Care Clin. 19: 33-53 (2003)

7. Mullis H.B., Copland T.S., Weinhold S.P., Miclau T., Lester E.G., Bos D.G.: Effect of COX-2 inhibitors in non-steroidal anti-inflammatory drugs on a mouse fracture model. Injury 37: 827-837 (2006)

8. Simon A.M., Manigrasso M.B., O’ Connor J.P.: Cyclo-oxygenase-2 function is essential for bone fracture heal­ing. J. Bone Miner. Res. 17: 977-978 (2002)

9. Zhang X., Schwarz E.M., Young D.A., Puzas J.E., Roiser R.N., O’Keffe R.J.: Cyclooxygenase-2 regulates mesechymal cell differentiation into the osteoblast lineage and is critically involved in bone repair. J. Clin. Invest. 109: 1405-1415 (2002)

10. Adohpson P., Abbaszadeghan H., Jonsson U., Dalen N., Sjoberg H.E., Kalen S.: No effects of pirozicam on os­teopenia and recovery after Colles ‘s fracture. Arch. Orthop. Trauma Surg. 112: 127-130 (1993)

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Άρθρα Δημοσιευμένα στην Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση
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