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Τίτλος – Title
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Τροποποίηση του Ηπατικού Μεταβολισμού της Τεστοστερόνης και Μπουφουραλόλης μετά από Έκθεση σε Stress Stress Modifies Testosterone and Bufuralol Metabolism in the Rat Liver |
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Συγγραφέας – Author
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Ευάγγελος-Παναγιώτης Δασκαλόπουλος1, Magnus Ingelman-Sundberg2, Matti A. Lang3, Μάριος Μαρσέλος1 και Μαρία Κωνσταντή1* 1Εργαστήριο Φαρμακολογίας, Ιατρική Σχολή, Πανεπιστήμιο Ιωαννίνων, Ιωάννινα GR-45110, Ελλάς. 2Karolinska Institutet, Dept of Physiology and Pharmacology, Medical School, Stockholm, Sweden 3Division of Biochemistry, Faculty of Pharmacy, University of Uppsala, Box578S75123, Uppsala, Sweden Evangelos-Panagiotis Daskalopoulos1, Magnus Ingelman-Sundberg2, Matti A. Lang3, Marios Marselos1 and Maria Konstandi1* 1Dept of Pharmacology, Medical School, University of Ioannina, Ioannina GR-451 10, Greece2Karolinska Institutet, Dept of Physiology and Pharmacology, Medical School, Stockholm, Sweden3 Division of Biochemistry, Faculty of Pharmacy, University of Uppsala, Box578S75123, Uppsala, Sweden |
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Παραπομπή – Citation
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Δασκαλόπουλος,Ε.-Π., Ingelman-Sundberg,Μ., Lang,Α.-L., Μαρσέλος,M., Κωνσταντή,M. : Τροποποίηση του Ηπατικού Μεταβολισμού της Τεστοστερόνης και Μπουφουραλόλης μετά από Έκθεση σε Stress, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 25: 35-37 (2007)
Daskalopoulos,E.-P., Ingelman-Sundberg,Μ., Lang,M.-A., Marselos,M., Konstandi,M. : Stress Modifies Testosterone and Bufuralol Metabolism in the Rat Liver, Epitheorese Klin. Farmakol. Farmakokinet. 25: 35-37 (2007)
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Ημερομηνία Δημοσιευσης – Publication Date
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2007 – 2007
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Γλώσσα Πλήρους Κειμένου –
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Ελληνικά – Greek |
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Λέξεις κλειδιά – Keywords
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Testosterone, bufuralol, metabolism, stress, rat liver
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Λοιποί Όροι – Other Terms
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Άρθρο Article |
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Περίληψη – Summary
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Cytochromes CYP3A, CYP2A, CYP2C και CYP2D are involved in the metabolism of numerous drugs and toxic compounds, such as environmental pollutants, pre-carcinogens and carcinogens. Stress increases the vulnerability of the exposed organism in developing cancer and immune diseases. The present study investigated the effect of psychological stress in the regulation of the afore-mentioned drug-metabolizing enzymes. For this purpose, repeated restraint stress was employed as experimental model of stress. The data showed that stress up-regulated the bufuralol 1΄-hydroxylase, 7a-, and 6b-testosterone hydroxylase activities that are catalysed by cytochromes CYP2D1/4, CYP3A1/2 and CYP2A, respectively. In contrast, stress did not affect 2a- and 16a-testosterone hydroxylase activities. Changes in apoprotein levels followed those of enzymatic activities. It appears that stress may modify the expression of several significant drug-metabolizing enzymes, thus affecting the effectiveness and toxicity of the drug therapy.
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Αναφορές – References
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1. Gonzalez F.J., Gelboin H.V.: Role of human cytochromes P450. In: The Metabolic Activation of Chemical Carcinogens and Toxins. Drug Metabol. Rev. 26: 165-183 (1994)
2. Wilkinson G.R.: Cytochrome P4503A (CYP3A) metabolism: Prediction of in vivo activity in humans. J. Pharmacokinet. Biopharmac. 24(5): (1996) 3. Daniel W.A., Haduch A., Wojcikowski J.: Inhibition of rat liver CYP2D in vitro and after 1-day and long-term exposure to neuroleptics in vivo-possible involvement of different mechanisms. Eur. Neuropsychopharmacol. 15: 103-110 (2005) 4. Konstandi M., Kostakis D., Harkitis P., Johnson E.O., Marselos M., Adamidis K., Lang M.A.: Benzo(alpha)pyrene-induced up-regulation of CYP1A2 gene expression: role of adrenoceptor-linked signaling pathways. Life Sciences 20;79: 331-341 (2006) 5. Konstandi M., Kostakis D., Harkitis P., Marselos M., Johnson E.O., Adamidis K., Lang M.A.: Role of adrenoceptor-linked signaling pathways in the regulation of CYP1A1 gene expression. Biochem. Pharmacol. 15;69: 277-287 (2005) 6. Westlind A., Loftberg L., Tindberg N., Andersson T.B., Ingelman-Sundberg M.: Interindividual differences in hepatic expression of CYP3A4: Relationship to genetic polymorphism in the 5’-upstream regulatory region. Biochem. Biophys. Res. Commun. 259: 201-205 (1999) 7. Crespi C.L., Chang T.K., Waxman D.J.: CYP2D6-dependent bufuralol 1’-hydroxylation assayed by reverse-phase ion-pair high-performance liquid chromatography with fluorescence detection. Methods Mol. Biol. 320: 121-125 (2006) |
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Online ISSN 1011-6575
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