Τόμος 33 (2015) – Τεύχος 3 – Άρθρο 3 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 33 (2015) – Issue 3 – Article 3 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Τίτλος – Title
Κανναβινοειδή στη Θεραπευτική. Κριτική Προσέγγιση στο Φυτό της Κάνναβης: Ιατρο­κοινωνικά Δεδομένα, Υποδοχείς Κανναβινοειδών, Θεραπευτικοί Στόχοι

Cannabinoids in Therapy. A Critical Approach to the Cannabis Plant: Medical and Social Data, Cannabinoids Receptors, Potential Thera-peutic Aspects

Συγγραφέας – Author

Παναγιώτης Τζιτζής, Νικόλαος Στάικογλου, Πέτρος Παπαλέξης, Χρυσοβαλάντης Τσάντσας, Μαρία Μυρωνίδου-Τζουβελέκη

Α’ Εργαστήριο Φαρμακολογίας, Σχολή Επιστημών Υγείας, Ιατρικό Τμήμα, Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ) ,Θεσσαλονίκη, Ελλάς

Panagiotis Tzitzis, Nikolaos Staikoglou, Petros Papalexis, Chrysovalantis Tsantsas, Maria Mironidou-Tzouveleki

A’ Laboratory of Pharmacology, Faculty of Health Sciences, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece

Παραπομπή – Citation
Τζιτζής,Π., Στάικογλου,Ν., Παπαλέξης,Π., Τσάντσας,Χ., Μυρωνίδου-Τζουβελέκη,Μ. : Κανναβινοειδή στη Θεραπευτική. Κριτική Προσέγγιση στο Φυτό της Κάνναβης: Ιατρο­κοινωνικά Δεδομένα, Υποδοχείς Κανναβινοειδών, Θεραπευτικοί Στόχοι, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 33: 223-239 (2015)
Tzitzis,P., Staikoglou,N., Papalexis,P., Tsantsas,C., Mironidou-Tzouveleki,M. : Cannabinoids in Therapy. A Critical Approach to the Cannabis Plant: Medical and Social Data, Cannabinoids Receptors, Potential Therapeutic Aspects, Epitheorese Klin. Farmakol. Farmakokinet. 33: 223-239 (2015)
Ημερομηνία Δημοσιευσης – Publication Date
3 Σεπτεμβρίου 2015 – 2015-09-03
Γλώσσα Πλήρους Κειμένου –
Full Text Language

Ελληνικά – Greek

Παραγγελία – Αγορά –
Order – Buy
Ηλεκτρονική Μορφή: pdf (15 €)
Digital Type: pdf (15 €)
pharmakonpress[at]pharmakonpress[.]gr
Λέξεις κλειδιά – Keywords
Κάνναβη, ιατρική κάνναβη, υποδοχείς κανναβινοειδών, θεραπεία, αντιφλεγμονώδης δράση
Cannabis, medical cannabis, cannabinoid receptors, treatments, anti-inflammatory effect
Λοιποί Όροι – Other Terms

Άρθρο

Article

Περίληψη – Summary
Η κάνναβη αποτελεί ένα από τα πλέον αμφιλεγόμενα φυτά στην ανθρώπινη ιστορία. Μαρτυρίες αναφέρονται τόσο στην κλωστική της ιδιότητα, όσο και στην ψυχοδραστική. Το πολυσυζητημένο αυτό φυτό, πλούσιο σε ποικιλία δραστικών ουσιών, ξεχώρισε από  την αρχαία εποχή και για τις θεραπευτικές του ιδιότητες. Εξαιτίας της επίδρασής του στην ψυχική σφαίρα άρχισε να ποινικοποιείται από το 12ο αιώνα λαμβάνοντας δια­στάσεις  κοινωνικού ζητήματος μέχρι σήμερα. Στις ημέ­ρες μας, συνεχίζει να αποτελεί παράνομη ναρκωτική ουσία στην πλειονότητα των Χωρών, όμως γίνονται προσπάθειες αποποινικοποίησής της, δίνοντας έμφαση, αυτή τη φορά, στα θεραπευτικά της οφέλη (ιατρική κάνναβη-medical cannabis). Τα μέχρι στιγμής δεδομένα είναι ιδιαίτερα ενθαρρυντικά, τόσο στη διερεύνηση της κυτταρικής σηματοδότησης του Ενδοκανναβινοειδούς Συστήματος, όσο και στην ανεύρεση θεραπευτικής ωφέ­λειας σε παθήσεις του ΚΝΣ, στον καρκίνο, στη φλεγ­μονή, στο Καρδιαγγειακό Σύστημα, στο μεταβολισμό. Τον Μάρτιο του 2014, η Υπηρεσία Δημόσιας Υγείας των ΗΠΑ ενέκρινε μελέτη για την ιατρική μαριχουάνα, σημαίνοντας μία ιστορική αλλαγή στην Ομοσπονδιακή πολιτική των ΗΠΑ. Στη Χώρα μας, μέχρι  στιγμής, δεν έχει δοθεί καμία έγκριση για κυκλοφορία κάποιου σκευά­σματος. Παρόλα αυτά έχει διαμορφωθεί ένα ιδιαίτερο νομικό καθεστώς για την ποινική μεταχείριση του χρή­στη κάνναβης. Συμπερασματικά, παραμένουν αρκετά ηθικά, κοινωνικά και επιστημονικά ζητήματα τα οποία πρέπει να αποσα­φηνιστούν, ώστε να τεθεί ένα ασφαλές και κοινωνικά αποδεκτό πλαίσιο όσον αφορά τη θεραπευτική της ωφέ­λεια.

Cannabis is one of the most controversial plants in human history. Historic evidence refers to both its psychoactive and weaving properties. This rich variety of active substances plant began to stand out, since ancient times for its therapeutic properties as well. However, due to its impact on the mental sphere, it was penalized in the 12th Century having aroused social issues since then. Nowadays, it is still considered to be an illegal narcotic substance in most countries, but there are efforts of its decriminalization, this time emphasizing its therapeutic benefits (medical cannabis). The data so far are very encouraging to both the investigation of cell signalling of the endocannabinoid system and the discovery of therapeutic benefit in CNS diseases, cancer, inflammation, cardiovascular and metabolism. In March 2014 the US Public Health Service approved a study for medical marijuana which indicates. This fact consist a historic change in the United State’s Federal Reserve policy. In our country, no approval for the circulation of any preparation has been given so far, but a special legal regime for the criminal treatment of cannabis user has been formed. In conclusion, there are several ethical, social and scientific issues that must be clarified in order to put a safe and socially acceptable framework for the therapeutic benefit, eliminating the risk of dependence at the same time.

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