Τόμος 20 (2002) – Τεύχος 1 – Άρθρο 4 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 20 (2002) – Issue 1 – Article 4 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Δημήτριος Ι. Χανιώτης¹, Λυγερή Π. Σούμπαση², Φραγκίσκος Ι. Χανιώτης³

¹ Εργαστήριο Πειραματικής Φυσιολογίας, Ιατρική Σχολή, Πανεπιστήμιο Αθηνών, Αθήνα, Ελλάς ² Νεφρολογικό Τμήμα, Περιφερειακό Γενικό Νοσοκομείο Αθηνών Αλεξάνδρα, Αθήνα, Ελλάς ³ Σχολή Επαγγελμάτων Υγείας και Πρόνοιας, Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας, Αθήνα, Ελλάς

Dimitrios I. Chaniotis¹, Lygeri P. Soubassi², Fragiskos I. Chaniotis³

¹ Department of Experimental Physiology, Uni­versity of Athens, Medical School, Athens, Greece ² Department of Nephrology, Alexandra Hospi­tal, Athens, Greece ³ Faculty of Health and Caring Professions, Technological Educational Institution (TEI) of Athens, Athens, Greece

2. Stenvinkel P., Lonnqvist F., Schalling M.: Molecular studies of leptin: implications for renal disease. Nephrol. Dial. Transplant. 14: 1103-1112 (1999)

2a. Βάθη Γ., Βιολάκη Ν., Συμεωνίδης Σ., Παϊκοπούλου Δ., Πλέσσας Σ.Τ.: Λεπτίνη: Ο ρόλος μιας νέας ορμόνης στην αιτιολογία και στη θεραπεία της παχυσαρκίας. Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής 14: 141-151 (1996)

2β. Δημουλά Υ., Κούρτης Π., Βιολάκη Ν., Μαργαρίτη Γ., Πλέσσας Σ.Τ.: Παχυσαρκία και ορμόνες. Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής 17: 137-152 (1999)

3. Shek E., Brands M.W., Hall J.E.: Chronic leptin infusion increases arterial pressure. Hypertension 31: 409-414 (1998)

4. Casto R.M., Van Ness J.M., Overton J.M.: Effects of central leptin administration on blood pressure in nor­motensive rats. Neurosci. Lett. 246: 29-32 (1998)

5. Hiraoka I., Hosoda K., Ogawa Y. et al.: Augmentation of obese (ob) gene expression and leptin secretion in obese spontaneously hypertensive rats (obese SHR or Koletsky rats). Biochem. Biophys. Res. Commun. 231: 582-585 (1997)

6. Ogawa Y., Masuzaki H., Aizawa M. et a!.: Blood pres­sure elevation in transgenic mice overexpressing leptin, the obese gene product. J. Hypertens. 16 (Suppl 2): 7 (1998)

7. Agata J., Masuda A., Takada M. et al.: High plasma immunoreac­tive leptin levels in essential hypertension. Am. J. Hypertens. 10: 1171-1174 (1997)

8. Uckaya G., Ozata M., Sonmez A. et al.: Plasma leptin levels strongly correlate with plasma renin activity in pa­tients with essential hypertension. Horm. Metab. Res. 31: 435-438 (1999)

9. Kokot F., Adamczak M., Wiecek A., Cieplok J.: Does leptin play a role in the pathogenesis of essential hyper­tension? Kidney Blood Press. Res. 22: 154-160 (1999)

10. Hirose H., Saito I., Tsujioka M., Mon M., Kawabe H., Satuta T.: The obese gene product, leptin: possible role in obesity-related hypertension in adolescents. J. Hypertens. 16: 2007-2012 (1998)

11. Narkiewicz K., Somers V.K., Mos L., Kato M., Accurso V., Palatini P.: An independent relationship between plasma leptin and heart rate in untreated patients with essential hypertension. J. Hypertens. 17: 245-249 (1999)

12. Suter P.M., Locher R., Hasler E., Vetter W.: Is there a role for the ob gene product leptin in essential hyperten­sion? Am. J. Hypertens. 11: 1305-1311 (1998)

13. Kennedy A., Gettys J.W, Watson P., et al.: The meta­bolic signific­ance of leptin in humans: gender-based differ­ences in relationship to adiposity, insulin sensitivity, and energy metabolism. J. Clin. Endocrinol. Metab. 82: 1293-1300 (1997)

14. Makris T.K., Stavroulakis G.A., Krespi P.G. et al.: Elevated plasma immunoreactive leptin levels preexist in healthy offspring of patients with essential hypertension. Am. Heart J. 138: 922-925 (1999)

15. Stenvinkel P., Heimburger 0., Lonnqvist F.: Serum leptin concentrations correlate to plasma insulin concen­trations independent of body fat content in chronic renal failure. Nephro.l Dial. Transplant. 12: 1321-1325 (1997)

16. Stenvinkel P., Bounder J., Alvestrand A.: Effects of insulin on renal haemodynamics and the proximal and distal sodiun handling in healthy subjects. Diabetologia 35: 1042-1048 (1992)

17. Jackson E.K., Li P.: Human leptin has natriuretic activ­ity in rat Am. J. Physiol. 272: F333-338 (1997)

18. Kolaczynski J.W., Nyce M.R., Considine R.V., et al.: Acute any chronic effect of insulin on leptin production in humans. Diabetes 45: 699-701 (1996)

19. Hall J.E., Brands M.W., Mizelle H.L., Gaillard C.A., Hildebrand D.A.: Chronic intrarenal hyperinsulinaemia does not cause hyper tension. Am. J. Physiol. 260: F663-669 (1991)

20. Villarreal D., Reams G., Freeman R.H., Taraben A.: Renal effects of leptin in normotensive, hypertensive, and obese rats. Am. J. Physiol. 275: R2056-2060 (1998)

21. Karlson C., Lindell K., Ottoson M., Sjostrom L., Carlsson B., Carlsson L.M.: Human adipose tissue expresses angiotensinogen and enzymes required for its conversion to angiotensin II. J. Clin. Endocrinol. Metab. 83: 3925-2929 (1998)

22. Frederich R.C.J., Kahn B.B., Peach M.I.: Tissue specific nutritiona regulation of angiotensinogen in adipose tissue. Hypertension 19: 339-344 (1992)

23. Schon U., Blaschke K., Turan S., Distler A., Sharma A.M.: Relationship between angiotensinogen, leptin and blood pressure levels in young normotensive men. J. Hypertens. 16:1475-1480 (1996)

24. Aubert I., Darimont C., Safonova I., Ailhaud G., Negrel R.: Regulation by glucocorticoids of angiotensinogen gene expres­sion and secretion in adipose cells. Biochem. J. 328: 701-706 (1997)

25. Jones B.H., Standridge M.K., Taylor J.W., Moustaid N.: Angiotensinogen gene expression in adipose tissue: analysis of obese models and hormonal and nutritional control. Am. J. Physiol. 273: R236-242 (1997)

26. Scherer U., Randin D., Tappy L., Vollenweider P., Jequier E., Nicod P.: Body fat and sympathetic nerve activity in health subjects. Circulation 89: 2634-2640 (1994)

27. Dunbar J.C., Hu Y., Lu H.: Intracerebroventricular leptin increase lumbar and renal sympathetic nerve activity and blood pressur in normal rats. Diabetes 46: 2040-2043 (1997)

28. Snikter S.. Pratley R.E., Nicolson M., Tataranni P.A,. Ravussin: Relationship between muscle sympathetic nerve activity an plasma leptin concentrations. Obes. Res. 5: 338-340 (1997)

29. Rutkowski M.P., Klanke C.A., Su Y.R., Reif M,, Menon A,G.: Genetic markers at the leptin (OB) locus are not significantly linked hypertension in African Americans. Hypertension 31: 1230-1236 (1998)

30. Ducy P., Amling M., Takeda S. et al.: Leptin inhibits bone formation through a hypothalamic relay: A central control of bone mass. Cell 100: 197-207 (2000)