Τόμος 15 (1997) – Τεύχος 1 – Άρθρο 6 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 15 (1997) – Issue 1 – Article 6 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Από | | Άρθρο - Article, Γεώργιος Ν. Κουκούλης,Georgios Koukoulis, Πλήρες Κείμενο στα Ελληνικά - Full Text in Greek

 

Τίτλος – Title

Νευ­ρο­α­νο­σο­εν­δο­κρι­νο­λογία: Κυτ­τα­ροκίνες και Γονάδες

Neuroimmunoendocrinology: Cytokines and Gonads
Συγγραφέας – Author

Γεώργιος Ν. Κουκούλης

Ενδοκρινολογική Κλινική και Τμήμα Έρευνας 251 Γενικού Νοσοκομείου Αεροπορίας

Georgios Koukoulis

Endocrinological Clinics and Research Depart­ment of 251 General Hospital of Aviation, 3 Kate­chaki str., Goudi, 115 25 Athens, Greece
Παραπομπή – Citation

Κουκούλης,Γ.Ν. : Νευ­ρο­α­νο­σο­εν­δο­κρι­νο­λογία: Κυτ­τα­ροκίνες και Γονάδες , Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 15 :  55-64 (1997)

Koukoulis,G.N. : Neuroimmunoendocrinology: Cytokines and Gonads, Epitheorese Klin. Farmakol. Farmakokinet. 15 : 55-64 (1997)
Ημερομηνία Δημοσιευσης – Publication Date
10-03-1997
Γλώσσα Πλήρους Κειμένου –
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Λέξεις κλειδιά – Keywords

Νευροανοσοενδοκρινολογία, κυτταροκίνες, γονάδες

Neuroimmunoendocrinology, kytokines, gonads
Λοιποί Όροι – Other Terms

Άρθρο

Article
Περίληψη – Summary

Η πα­ρου­σί­α ση­μα­ντι­κών αλ­λη­λε­πι­δρά­σε­ων με­τα­ξύ του α­να­πα­ρα­γω­γι­κού και του α­νο­σο­λο­γι­κού συ­στή­μα­τος εί­ναι γνώ­ση που έ­χει α­πο­κτη­θεί πρό­σφα­τα. Τα στε­ρο­ει­δή των γο­νά­δων ε­πη­ρε­ά­ζουν τη συ­μπε­ρι­φο­ρά του α­νο­σο­λο­γι­κού συ­στή­μα­τος και, α­ντί­στοι­χα, οι κυτ­τα­ρο­κί­νες, προι­ό­ντα των κυτ­τάρων του α­νο­σο­λο­γι­κού συ­στή­μα­τος, πα­ρεμ­βαί­νουν στη ρύθ­μι­ση της γο­να­δι­κής λει­τουρ­γί­ας. Οι κυτ­τα­ρο­κί­νες συμ­με­τέ­χουν, ε­πί­σης, στην α­ντί­δρα­ση προ­σαρ­μο­γής του ορ­γα­νι­σμού σε κα­τα­στά­σεις στρες με στό­χο την α­πο­κα­τά­στα­ση της ο­μοι­ο­στα­σί­ας. Οι γο­νά­δες α­πο­τε­λούν θέ­σεις πα­ρα­γω­γής της ι­ντερ­λευ­κί­νης-1, της ι­ντερ­λευ­κί­νης-6 και της ι­ντερ­λευ­κί­νης-8, οι ο­ποί­ες θε­ω­ρεί­ται ο­τι συμ­με­τέ­χουν στη ρύθ­μι­ση της λει­τουρ­γί­ας τους α­σκώ­ντας πα­ρα­κρι­νι­κή ή/και  αυ­το­κρι­νι­κή δρά­ση. Ε­πι­πλέ­ον, τα κύτ­τα­ρα των γο­νά­δων συν­θέ­τουν και εκ­κρί­νουν την υ­πο­θα­λα­μι­κή ορ­μό­νη CRH. Οι θέ­σεις πα­ρα­γω­γής των ανωτέρω ι­ντερ­λευ­κι­νών και της CRH, οι πα­ρά­γο­ντες που ε­πη­ρε­ά­ζουν την έκ­κρι­σή τους και η σημα­σί­α τους για τη λει­τουρ­γί­α των γο­νά­δων α­πο­τε­λούν το α­ντι­κεί­με­νο του πα­ρό­ντος άρ­θρου.

Cytokines are soluble polypeptides released from cells of thw immune system. Their production in endocrine glands and their actions on hormone-responsive cells is currently a subject of intense research interest. The presence of fundamental interrelationships between the im­mune and reproductive systems is well illustrated by the notion that survival for a livivng organism is known to depend on a well programmed system that prevents invation by other organisms and an efficient reproductive system. Communication between the gonadal axis and the immune system has been proposed for over a century, although in recent years the existence of a reciprocal rela­tionship between the hypothalamic-hypophyseal-gonadal axis and the immune system has gained even more attention. The gonadal steroids influ­ence the  function of immune system and  cytoki­nes  regulate the  gonadal function. Cytokines mediate the extensive interaction between the immune system and the hypothalamic-pituitary axis in order to reestablish homeostasis. Inter-leuk­in-1, interleukin-6, interleukin-8  and CRH are produced by gonadal somatic cells and there is strong evidence for their involvement in the regulation of gonadal function. The aim of this article is to review  the sites of their production, the factors that affect their secretion and to speculate upon physiological and pathophysiologi­cal significance.

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