Τόμος 12 (1994) – Τεύχος 3 – Άρθρο 2 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 12 (1994) – Issue 3 – Article 2 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Από | | Αγαθοκλής Τσατσούλης - Agathoklis Tsatsoulis, Άγγελος Ευαγγέλου - Angelos Evangelou, Άρθρο - Article, Γ. Μανουσάκου,G. Manousakis, Πλήρες Κείμενο στα Ελληνικά - Full Text in Greek, Τ.Α. Καβάνος,T.A. Kabanos

 

Τίτλος – Title

Η ινσουλινομιμητική δράση του βαναδίου

Insulinomimetic Activity of Vanadium
Συγγραφέας – Author

Α. Τσατσούλης, Α. Ευαγγέλου, Γ. Μανουσάκου, Τ.Α. Καβάνος4

1 Εργαστήριο Ενδοκρινολογίας, Ιατρική Σχολή, Πανεπιστήμιο Ιωαννίνων, 45110 Ιωάννινα, Ελλάδα 2 Εργαστήριο Πειραματικής Φυσιολογίας, Ιατρική Σχολή Πανεπιστημίου Ιωαννίνων, 45 332 Ιωάννινα 3 Εργαστήριο Ανόργανης Χημείας, Τμήμα Χημείας, Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης , 540 06 Θεσσαλονίκη 4 Εργαστήριο Ανόργανης Χημείας, Τμήμα Χημείας, Πανεπιστήμιο Ιωαννίνων, 45 110 Ιωάννινα, Ελλάδα

A. Tsatsoulis1, A. Evangelou2, G. Manousakis3 and T.A. Kabanos4

1 Laboratory of Endocrinology, Faculty of Medi­cine, University of Ioannina, 45110 Ioannina, Greece 2 Laboratory of Experimental Physiology, Faculty of Medicine, University of Ioannina, 45 332 Ioan­nina, Greece 3 Laboratory of Inorganic Chemistry, Department of Chemistry, Aristotelian University of Thessalo­niki, 540 06 Thessaloniki, Greece 4 Laboratory of Inorganic Chemistry, Department of Chemistry, University of Ioannina, 45 110 Ioan­nina, Greece
Παραπομπή – Citation

Τσατσούλης,Α.,  Ευαγγέλου,A., Μανουσάκου,Γ., Καβάνος,Κ.Α. : Η ινσουλινομιμητική δράση του βαναδίου , Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 12 : 123-134 (1994)

Tsatsoulis,A.,  Evangelou,A., Manousakis,G., Kabanos,T.A. : Insulinomimetic Activity of Vanadium , Epitheorese Klin. Farmakol. Farmakokinet. 12 : 123-134 (1994)
Ημερομηνία Δημοσιευσης – Publication Date
–
Γλώσσα Πλήρους Κειμένου –
Full Text Language

Ελληνικά – Greek
Παραγγελία – Αγορά –
Order – Buy
Ηλεκτρονική Μορφή: pdf (15 €) –
Digital Type: pdf (15 €)
pharmakonpress[at]pharmakonpress[.]gr
Λέξεις κλειδιά – Keywords

Σακ­χα­ρώ­δης δια­βή­της, ιν­σου­λι­νο­μι­μη­τι­κή δρά­ση, ε­νώ­σεις βα­να­δί­ου, δια­βη­τι­κοί α­ρου­ραί­οι με χρή­ση στρε­πτο­ζο­το­σί­νης, ε­νώ­σεις βα­να­δί­ου με βελ­τιω­μέ­νη κυτ­τα­ρι­κή δια­πε­ρα­τό­τη­τα, ε­λατ­τω­μέ­νη το­ξι­κό­τη­τα, μη­χα­νι­σμός δρά­σης του βα­να­δί­ου, ιν­σου­λι­νι­κός υ­πο­δο­χέ­ας

Diabetes mellitus, insulinomimetic activity, vanadium compounds, streptozo­tocin-treated rats, reduced toxicity, mechanism of action of vanadium, insulin receptor
Λοιποί Όροι – Other Terms

Άρθρο

Article
Περίληψη – Summary

Η γλυ­κό­ζη, φυ­σιο­λο­γι­κός ρυθ­μι­στής του με­τα­βο­λι­σμού του γλυ­κο­γό­νου στο ή­παρ, α­να­στέλ­λει (ά­με­σα) τη δρά­ση της γλυ­κο­γο­νι­κής φω­σφο­ρυ­λά­σης και ε­νερ­γο­ποι­ε­ί (έμ­με­σα) τη δρά­ση της γλυ­κο­γο­νι­κής συν­θε­τά­σης. Παρά­γω­γα της γλυ­κό­ζης, με ι­σχυρό­τε­ρη α­να­σταλ­τι­κή δρά­ση έ­να­ντι της γλυ­κο­γο­νι­κής φω­σφο­ρυ­λά­σης, μπο­ρεί να έ­χουν κα­λύ­τε­ρες ρυθ­μι­στι­κές ι­διό­τη­τες, με­τα­το­πί­ζο­ντας την ι­σορ­ρο­πί­α με­τα­ξύ α­ποι­κο­δό­μη­σης και σύν­θε­σης γλυ­κο­γό­νου προς την κα­τεύ­θυν­ση της σύν­θε­σης, και ως εκ τού­του κλι­νι­κό εν­δια­φέ­ρον στην α­ντι­με­τώ­πι­ση του σακ­χα­ρώδη δια­βή­τη (τύ­που Ι­Ι), ό­που η α­δυ­να­μί­α κα­τα­στο­λής της πα­ρα­γω­γής γλυ­κό­ζης εί­ναι α­πό τις κύ­ριες εκ­δη­λώ­σεις της α­σθενεί­ας. Η γνώ­ση της τρισ­διά­στα­της δο­μής της γλυ­κο­γο­νι­κής φω­σφο­ρυ­λά­σης, σε υ­ψη­λή ευ­κρί­νεια, πα­ρέ­χει τη δυ­να­τό­τη­τα σχε­δια­σμού πα­ρα­γώ­γων γλυ­κό­ζης, με αυ­ξη­μέ­νη (συ­γκρι­τι­κά με τη γλυ­κό­ζη) συγ­γέ­νει­α σύν­δε­σης προς το εν­ζυ­μι­κό μό­ριο. Πε­ρι­γρά­φο­νται κι­νη­τι­κά και κρυ­σταλ­λο­γρα­φι­κά α­πο­τε­λέ­σμα­τα μιας νέ­ας σει­ράς α­να­στο­λέ­ων της GPb, πα­ρα­γώ­γων της β-D-γλυκό­ζης.

Research efforts for the improve­ment of the treatment of Diabetes Mellitus have led to the discovery and development of new substances with insulin mimetic effects. Important among these are the Vanadium compounds. In vitro studies in various cellular systems have shown that vanadium salts can mimic almost all of the metabolic effects of insulin. These include the stimulation of glucose transport and oxidation, the stimulation of lipogenesis and inhibition of lipolysis, the activation of glycogen synthase and the enhancement of K+ uptake ad Ca2+ influx into the cells. In vivo  studies in experimental and genetic models of diabetic animals have shown that oral administration of vanadium salts can dramatically improve the diabetic state. Thus administration of vanadium salts in Streptozoto­cin-treated rats resulted in normalization of blood glucose levels and correction of the lipid distur­bances. Further studies in genetic models of type II diabetes have shown that treatment with vana­dium maintains glucose homeostasis and im­proves peripheric tissue responses to insulin. Parallel research has focused on the development of new vanadium compounds with improved cell membrane permeability and thus biological affinity with less toxic effects. Experimental studies have shown that these compounds are more effective. The mechanism of action of vanadium is not clearly known. It appears from the available evi­dence that vanadate exerts its metabolic effects by either an alternative (insulin-independent) cas­cade mechanism or at least by bypassing the early (receptor) events in the cascade. In con­clusion, vanadium and its compounds can mimic effectively most of insulin’s actions in-vitro  and in vivo. Further longer term studies in diabetic ani­mals are needed in order to substantiate the beneficial effects of vanadium are lasting and without major toxic consequences, before phase I, human studies can be undertaken.
Αναφορές – References
  1. Atkinson, M.A., Maclaren, N.K.: What causes diabetes? Sci. Am. 263: 62-71 (1990)
  2. Reach, G., Wilson, G.W.: Can continuous glu­cose monitoring be used for the treatment of diabe­tes? Anal. Chem. 64:  381A-386A (1992)
  3. Reviewed in: Shechter, Y. Insulin-mimetic effects of vanadate: possible implications for future treat­ment of diabetes. Diabetes 39: 1-5 (1990)Shechter, Y., Meyerovitch, J., Farfel, Z., Sack, J., Bruk, R., Bar-Meir, S., Amir, S., Degani, H., Karlish, S.J.D.: Insulin Mimetic effects of vanadium. In Va­nadium in Biological Systems: Physiology and Bio­chemistry (Chasteen, N.D., ed.), Kluwer Academic Publishers: Dordrecht, pp 129-142, (1990)
  4. Lyonnet, B., Martz, F., Martin, E.: L’ emploi therapeutique des derives du vanadium. Presse Med. 1: 191-192 (1899)
  5. Shechter, U., Karlish, S.J.D.: Insulin-like stimula­tion of glucose oxidation in rat adipocytes by vanadyl(IV) ions. Nature 284: 556-558 (1980)
  6. Dubyak, G.R., Kleinzeller, A.: The insulin-mi­metic effects of vanadate in isolated rat adipocytes. Dissociation from effects of vanadate as a (Na+-K+) ATPase inhibitor. J. Biol. Chem. 255(11): 5306-4312 (1980)
  7. Degani, H. et al.: Electron paramagnetic studies and insulin-like effects of vanadium in rat adipo­cytes. Biochemistry 20:  5795-5799 (1981)
  8. Heyliger, C.E., Tahiliani, A., McNeili, J.H.: Effect of vanadate on blood glucose and depressed car­diac performance of diabetic rats. Science (Washington, DC) 227:   1474-1477 (1985)
  9. Meyerovitch, J., Farfel, Z., Sack, J., Schechter, Y.: Oral administration of vanadate normalizes blood glucose levels in streptozotocin-treated rats. Char­acterization and mode of action. J. Biol. Chem. 262(14): 6658-6662 (1987)
  10. Paulson, D.J., Kopp, S.J., Tow, J.P., Peace, D.G.: Effects of vanadate on in vivo myocardial re­activity to norepinephrine in diabetic rats. J. Phar­macol. Exp. Ther. 240(2): 529-534 (1987)
  11. Brichard, S.M., Okitolonda, W., Henquin, J.C.: Long-term improvement of glucose homeostasis by vanadate treatment in diabetic rats. Endocrinology 123: 2048-2053 (1988)
  12. Gil, J., Miralpeix, M., Carreras. J., Bartrons, R.: Insulin-like effects of vanadate on glucokinase activ­ity and fructose 2,6-biphosphate levels in the liver of diabetic rats. J. Biol. Chem. 263: 1868-1871 (1988)
  13. Hudson, T.G.F.: Vanadium toxicology and bio­logical significance. Elsevier Monographs on Toxic Agents (Ed. E. Browing). Elsevier Publishing Com­pany, Amsterdam, London, New York, 1964
  14. Mongold, J.J., Gros, G.H., Vian, L., Tep, A., Ramanadham, S., Siou, G., Diaz, J., McNeill, J.H., Serrano, J.J.: Toxicological aspects of vanadyl s sulphate on diabetic rats: Effects on vanadium lev­els and pancreatic b-cell morphology. Pharmacol. Toxicol. 67: 192-198 (1990)
  15. Ramanadham, S., Cros, G.H., Mongold, J.J., Serrano, J.J., J.H.McNeill.: Enhanced in vivo sensi­tivity of vanadyl-treated diabetic rats to insulin. Can. J. Physiol. Pharmacol. 68: 486-491 (1990)
  16. Cross, G., Mongold, J.J., Serrano, J.J., Ra­manadham, S., McNeil, J.H.: Effects of vanadyl de­rivatives on animal models of diabetes. Mol. Cell Biochem. 109: 163-166 (1992)
  17. Macara, I.G.: Vanadium-an element in search of a role. Trends Biochem. 5: 92-94 (1980)
  18. Ramasarma, I., Crance, F.L.: Does vanadium play a role in cellular regulation? Curr. Top Coll., Regul. 20:  247-301 (1981)
  19. Simons, T.J.B.: Vanadate – a new tool for biolo­gists. Nature 281: 337-338 (1979)
  20. Nechay, B.R.: Mechanism of action of vana­dium. Ann. Rev .Pharmacol 24: 501-524 (1984)
  21. Fagin, J.A., et al.: Insulinotropic effects of vanadate. Diabetes 36: 1448-1452 (1987).
  22. Shechter, Y., Ron, A.: Effect of depletion of phosphate and bicarbonate ions on insulin action in rat adipocytes. J. Biol. Chem. 261: 14945-14950 (1986)
  23. Shechter, Y., Ron, A.: Effect of depletion of bi­carbonate or phosphate ions on insulin action in rat adipocytes. Further characterization of the receptor effector system. J. Biol. Chem. 261: 14951-14945 (1986)
  24. Shechter, Y., et al.: The use of post-binding agents in studying insulin action and its relation to experimental diabetes. Biochem Pharmacol. 37: 1891-1896 (1988)
  25. Duckworth, W.C., et al.: Insulin like effects of vanadate in isolated rat adipocytes. Endocrinology 122: 2285-2289 (1988)
  26. Dlouha, H., Tfeisinger, T., Vyskocil, F.: The ef­fect of vanadate on the electrogenic Na+/K+pump, intracellular Na+concentration and electro-physi­ological characteristics of mouse skeletal muscle ber. Physiol. Bohemosiov 30: 1-10 (1981)
  27. Tamura S., Brown T.A., Whipple J.H., Hama­guchi Y.F., Dubler R.E., Cheng. K., Larner J.: A novel mechanism of the insulin-like effects of vanadate on glycogen synthase in rat adipocytes. J. Biol. Chem. 259: 6650-58 (1984)
  28. Tolman E.L., Barris, E., Burns, M., Pansini, A., Partridge R: Effect of vanadium on glucose metabo­lism in vitro. Life Sci. 25: 1159-64 (1979)
  29. Hori, C. Oka, T.: Vanadate enhances the stimulatory action of insulin on DNA synthesis in cultured mouse mammary gland. Biochim. Biophys. Acta 610: 235-40 (1980)
  30. Canalis, E.: Effect of sodium vanadate on de­oxyribonucleic acid and protein synthesis on cul­tured rat calvaria. Endrocrinology 116: 855-62(1985)
  31. Smith, J.B.: Vanadium ions stimulate DNA syn­thesis in Swiss mouse 373 and 376 cells. Proc. Natl. Acad. Sci., USA 80: 6161-66 (1983)
  32. Kodad, S., Fantus, I.G., Hersh, B. Posner, B.L.: Vanadate stimulation of IGF-I binding to rat adipo­cytes. Biochem. Biophys. Res. Commun. 138: 174-78 (1986)
  33. Werdan, K., Bauriedel, G., Fischer, B., Krawitz, W., Erdmann, E., Schmitz, W., Scholz H: Stimula­tory (insulinmimetic) and inhibitory (ouabain like) action of vanadate on potassium uptake and cellular sodium and potassium in heart cells in culture. Biochim. Biophys. Acta 23: 79-93 (1982)
  34. Delfert, D.M., McDonald, J.M.: Vanadyl and vanadate inhibit Ca2+transport systems of the adi­pocyte plasma membrane and endoplasmic reticu­lum. Biochem Biophys 241: 665-672 (1985)
  35. Gausen, T., Anderson, T.L., Stu-Johansen, M., Petkova, O.: The relationship between the transport of glucose and cations across cell membranes in        isolated tissues. XI. The effect of vanadate on 45Ca-efflux and sugar transport in adipose tissue and skeletal muscle. Biochim Biophys Acta 646:  261-67 (1981)
  36. Cassci, D., Zhuang, Y.X., Glaser, L.: Vanadate stimulated Na+,H+exchange activity in A431 cells. Biochem. Biophys. Res. Commun. 118: 675-81 (1984)
  37. Malabu, U.H., Dryden, S., Mccarthy, H.D., Kilpa­trick, A., Williams, G.: Effects of chronic vanadate administration in the STZ-induced diabetic  rat. Dia­betes 43: 9 (1994)
  38. McNeill, J.H, Battell, M., Cam. M., Dai, S., Thompson, K., Yuen, V.: Oral vanadium and lower­ing of blood glucose. Diabetes 43: 1268 (1994)
  39. Domingo, J., Gomez, M., Sanchez, D.J., Lobet, J.M., Keen, C.L.: Relationship between reduction in food intake and amelioration of hyperglycemia by oral vanadate in STZ-induced diabetic rats. Diabetes 43: 1267 (1994)
  40. Brichard, S.M., Bailey, C.J., Henquin, J.C.: Marked improvement of glucose homeostasis in dia­betic ob/ob mice given oral vanadate. Diabetes 39: 1326 (1990)
  41. Meyerovitch, J., Rothenberg, P., Shechter, Y., Bonner-Weir, S.A, Kahn, C.R.: Vanadate normal­ises hyperglycaemia in two mouse models of non-insulin dependent diabetes mellitus. J. Clin. Invest. 87: 1286 (1991)
  42. Ramanadham, S., Brownsey, R.W., Cross, G.H., Mongold, J.J., McNeil, J.H.: Sustained pre­vention of myocardial and metabolic abnormalities in diabetic rats following withdrawal from oral vanadyl treatment. Metabolism 38: 1022 (1989)
  43. Brichard, S.M., Poltier, A.M., Henquin, J.C.: En­docrinology 125: 2510 (1989)
  44. Brichard, S.M., Assimacopoulos-Jeannet, F., Jeanrenand, B.: Endocrinology 131: 311 (1992)
  45. Lazaro, R., Cros, G., McNeill J.H., Serrano, J.J.: Complexed vanadium for the treatment of dia­betes mellitus. European Patent EP 3052 64, issued 1 March 1989.
  46. McNeill, J.H., Yuen, V.J., Hoveyda, H.R., Orv­ing, C: Bis(maltolato)oxo-vanadium(IV) is a potent insulin mimic. J. Med. Chem. 35: 1489 (1992)
  47. Ramanadham, S., Mongold, J.J., Brownsey, R.W., Cross, J.H., McNeil, J.H.: Vanadyl sulfate in the treatment of diabetes mellitus in rats. Am. J. Physiol. 257: 4904 (1989)
  48. Shechtor, Y., Shishera, A., Lazar, R., Libman J., Shanzer, A.: Hydrophobic carriers of vanadyl ions augment the insulinomimetic actions of vanadyl ions in rat adipocytes. Biochemistry 31: 2063 (1992)
  49. Posner, B.I., Shaver, A., Fantus, I.G.: In New Antidiabetic Drugs. C.J. Bailey, P.R. Flatt: Smith-Gordon, Chapter 8, pp. 107-117, London, 1990
  50. Fantus, I.G., Kadota, S., Deragon, G., Foster, B., Posner, B.I.: Perranadate [peroxide(s) of vanadate] mimics insulin action in rat adipocytes via activation of the insulin receptor tyrosine kinase. Biochemistry 28: 8864 (1989)
  51. Kadota, S., Fantus, I.G., Deragon, G., Guyda, H.J., Hersch, B., Posner, B.I.: Peroxides of vana­dium: a novel and potent insulin-mimetic agent which activates the insulin receptor kinase. Biochim. Biophys. Res. Commun. 147: 259 (1987)
  52. Kadota, S., Fantus, I.G., Deragon, G., Guyda, H.J., Posner, B.I.: Stimulation of insulin-like growth factor II receptor binding and insulin receptor kinase activity in rat adipocytes. J. Biol. Chem. 262: 8252 (1987)
  53. (a) Harrison, A.T., Howarth, O.W.: High-field vanadium-51 and oxygen-17 nuclear magnetic reso­nance study of peroxovanadates(v). J. Chem. Soc. Dalton Trans., 1173 (1985)
  54. b) Heath,E., Howarth, O.W.: Vanadium-51 and oxy­gen-17 nuclear magnetic resonance study of vanadate(v) equilibria and kinetics. Chem. Soc. Dalton Trans. 1105 (1981) (c) Howarth, O.W., Hunt, J.R.: Peroxo-complexes of vanadium(v); a vanadium-51 nuclear magnetic resonance study. J. Chem. Soc., Dalton Trans. 1388 (1979) (d) Campbell, N.J., Dengel, A.C., Grifith, W.P.: Studies of transition metal peroxo complexes-x. the nature of peroxovanadates          in aqueous solution. Polyhedron 8: 1379 (1989) (e) Tracey, A.S., Jaswal, J.S.: An NMR Investiga­tion of the Interactions occurring between per­oxovanadates and peptides. J. Am. Chem. Soc. 114: 3835 (1992) (f) Jaswal, J.S., Tracey, A.S.: Formation and de­composition of peroxovanadium(v) complexes in aqueous solution. Inorg. Chem. 30: 3718 (1991)
  55. Shaver, A., Ng, J.B., Hall, D.A., Lum, B.S., Posner, B.I.: Insulin-mimetic peroxovanadium com­plexes: preparation and structure of potassium oxo-diperoxo(3-hydroxypyridine-2-carboxylato)vanadate-(V), K2[VO(O2)2[C5H4NCOO)].2H2O and potassium oxodiperoxo(3-hydroxy-pyridine-2-carboxylato)vana-date(V), K2[VO(O2)2(OHC5H3NCO)].3H2O, and their reactions with cysteine. Inorg. Chem. 32: 3109 (1993)
  56. Swarup G., Speeg, K.V., Cohen, S., Garbers, D.L.: Phosphotyrosyl-protein phosphatase of TCRC-2 cells. J. Biol. Chem. 257: 7298 (1982)
  57. Schechter, Y.: Perspective in diabetes: insulin-mimetic effects of vanadate; possible implications for future treatment of diabetes. Diabetes 39: 1 (1990

Online ISSN 1011-6575

Άρθρα Δημοσιευμένα σε αυτό το Περιοδικό Καταχωρούνται στα:
• Chemical Abstracts

• Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE
SCImago Journal and Country Rank Factor

Articles published in this Journal are Indexed or Abstracted in:
• Chemical Abstracts
• Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE
SCImago Journal and Country Rank Factor

Άρθρα Δημοσιευμένα στην Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση
Articles Published in Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Συντακτικη Επιτροπή-Editorial Board

ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ – ANNUAL SUBSCRIPTION
Γλώσσα Πλήρους Κειμένου –
Full Text Language
Ελληνικά – Greek
Παραγγελία – Αγορά –
Order – Buy
Ηλεκτρονική Μορφή: pdf (70 €) –
Digital Type: pdf (70 €)
pharmakonpress[at]pharmakonpress[.]gr
Έντυπη Μορφή (70 € + έξοδα αποστολής)
Printed Type (70 € + shipping)
pharmakonpress[at]pharmakonpress[.]gr

 

Προσθέστε στους σελιδοδείκτες το μόνιμο σύνδεσμο.

Τα σχόλια είναι απενεργοποιημένα.