Τόμος 3 (1985) – Τεύχος 2 – Άρθρο 4 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 3 (1985) – Issue 2 – Article 4 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

A Comparative Pharmacokinetic Study of Different Formulations of the Anorectic Drug Dimethylpropion

S. L. MARKANTONIS, A. KYROUDIS AND A. H. BECKETT

^{Department of Pharmacy, Chelsea College, University of London}

3: 45-50 (1985)

PHARMAKON-Press: Epitheorese Klin. Farmakol. Farmakokinet.

3: 45-50 (1985)

Pharmacokinetic, Anorectic Drug, Dimethylpropion

The anorectic drug dimethylpro­pion (DMP I) was given to eight healthy vo­lunteers, either in the free form or in the form of controlled release pellets, and the rates of excretion of the drug and its metabolites into the urine was measured. A comparison of the results indicated the general superiority of the pellets over the free form. One of the batches of pellets was considered to be the most sui­table for therapeutic use, because therapeutic levels of the drug were maintained for 12 or even 24 hours without giving the high peaks usually responsible for the unwanted side ef­fects. Uncontrolled urinary pH was found to cause marked fluctuation in the urinary excretion rate of DMP I and its metabolites. When the pH of the urine exceeded pH 5.2 the urinary excre­tion rate decreased significantly.

1. Gibaldi, Μ.: Biopharmaceutics and Clinical Pharmacoki­netics, Lea and Febiger, Philadelphia, (1977)
2. Beckett, A.Η.: Drug Metabolism in Man, (Editors Gorrod, W., Beckett, A.H.), Chapter 2. Taylor and Francis, London (1978)
3. Beckett, Α.H.: Drug Absorption. Chapter 14, Proceedings of the Edinburgh International Conference, 1979 (Editors Prescott, L.F., Nimmo, W.S.), Adis Press (1981)
4. Robinson, J.R.: Sustained and Controlled Release Drug Delivery Systems (Editor), Marcel Dekker, New York ( 1978)
5. Julliano, R.L. (Editor): Drug Delivery Systems. University Press, Oxford (1980)