Τόμος 3 (1985) – Τεύχος 4 – Άρθρο 4 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 3 (1985) – Issue 4 – Article 4 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

The Effect of Formulation on the Bioavailability of a Drug

G. PAPAIOANNOU AND D. M. REKKAS

^{Τομέας Φαρμακευτικής Τεχνολογίας, Φαρμακευτικό Τμήμα Πανεπιστημίου Αθηνών}

3: 193-202 (1985)

PHARMAKON-Press: Epitheorese Klin. Farmakol. Farmakokinet.

3: 193-202 (1985)

Effect of Formulation, Drug Bioavailability

The purpose of this article is to indicate the mechanisms by which the ap­pearance, the duration and the extent of the therapeutical action of a drug are controlled, by the “designer” of the dosage form. Primary the physicochemical agents that influence bioavai­lability are referred, such as rate of dissolution, complexation, polymorphism and solvation. Af­terwards the effect of drug stability is describ­ed and also the effect of its dosage form on the bioavailability of the drug. Examples of con­trolled release dosage forms are also given and finally some pharmaceutical products, on which studies of bioequivalence have been made, are mentioned.

1. Martin, A., Swarbrick, J., Cammarata, A.: Physical Phar­macy and drug product design. Physical Pharmacy. 3rd Edition, Lea and Febiger, Philadelphia, p. 574 (1983)
2. Wagner, J., Factors affecting rate of dissolution and interpretation of dissolution rate data from in vivo testing of tablets and capsules. Biopharmaceutics and Relevant Pharmacokinetics, Hamilton, Illinois, p. 115 (1971)
3. Gibaldi, Μ.: Gastrointestinal absorption-Physicochemical considerations. Biopharmaceutics and Clinical Pharma­cokinetics, 3rd Edition, Lea and Febiger, Philadelphia, p. 44 (1984)
4. Wagner, J.: Relationships among form of drug, dosage form, routes of administration and concentration curves and urinary excretion curves. Biopharmaceutics and Re­levant Pharmacokinetics, Hamilton. Illinois, p. 61 (1971)
5. Gibaldi, Μ.: Gastrointestinal absorption-role of the do­sage form. Biopharmaceutics and Clinical Pharmacokine­tics, 3rd Edition, Lea and Febiger, Philadelphia, p. 64 (1984)