Τόμος 4 (1986) – Τεύχος 1 – Άρθρο 5 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 4 (1986) – Issue 1 – Article 5 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

A. ADAMOS AND J. GERAKIOU

^{CIBA-GEIGY ΕΛΛΑΣ, Ανθούσα Αττικής}

^{CIBA-GEIGY HELLAS LTD., Anthoussa Attiki}

3: 275-280 (1986)

PHARMAKON-Press: Epitheorese Klin. Farmakol. Farmakokinet.

3: 275-280 (1986)

A new galenic form for controlled release of drugs is the coated with multiporous membrane tablet. These tablets have a core with a soluble drug and a coating from a multiporous membrane, which consists of a water insoluble polymer. The pores of this membrane are sealed with sucrose particles. When the tablet is taken per os, gastric fluids dissolve the sucrose and thus pores open. After that the fluids of the gastrointestinal tube pass through the membrane porous and dissolve the drug, which in turn diffuses out of the membra­ne with a controlled and constant rate. The release of the drug from this galenic form is based on the law of molecular diffusion, Ad­vantage of this galenic form is the fact that the release of the drug is independent of pH and gastrointestinal motility.

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