Τόμος 4 (1986) – Τεύχος 1 – Άρθρο 4 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 4 (1986) – Issue 1 – Article 4 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Gr. N. TSEKOS AND G. RAMMOS

3: 259-274 (1986)

PHARMAKON-Press: Epitheorese Klin. Farmakol. Farmakokinet.

3: 259-274 (1986)

The nephrotoxicity of certain potentially nephrotoxic antibiotics such as old and new sulfonamides, penicillins, vancomy­cin, old and new tetracyclines, polymyxin Β and Ε and their clinical significance and laboratory consequences are reviewed in this paper. The mechanisms of nephrotoxicity, concurrent pre­disposing factors, pharmacokinetics related es­pecially to the renal function (absorption, re­nal excretion, removal by peritoneal dialysis and hemodialysis, protein binding, blood and urine levels, half-life e.t.c.), route of admini­stration and appropriate dosages in patients with normal and impaired renal function or in anephric patients as well as metabolism in general are stressed in more detail.

1. Schreiner, G.E., Maher, J.F.: Toxic nephropathy. Ann. J. Med 38: 409 (1965)
2. Weinstein, L., Madoff, M.A., Samet, C.M.: The sulfo­namides. N. Engl. J. Med. 263: 793 (1960)
3. Dowling, Η.F. Lepper, M.Η.: Toxic reactions following therapy with sulfapyridine, sulfadiazole and sulfadia­zine. J.A.M.A. 121: 1190 (1943)
4. Koch-Vesser, J., Sidel, V.W., Dexter, M. at al.: Adverse reaction to sulfisoxazole, sulfamethoxazole, and nitrofurantoin: manifestations and specific reaction rates du­ring 2.118 courses of therapy. Arch. Intern. Med. 128: 399 (1971)
5. Dorfman, L, Smith, J.R.: Sulfonamide crystalluria: a forgotten disease. J. Urol.  104: 482 (1970)