Τόμος 4 (1986) – Τεύχος 3 – Άρθρο 5 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 4 (1986) – Issue 3 – Article 5 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

The Influence of Amiodarone on a  Digitoxin and a Digogin like Substance in the Rabbit Serum

V. KOKKAS, K. L. PAPADOPOULOS, Α. KOUYOUMTZIS, G. SAKANTAMIS, M. KOTOULA AND A. MISSOPOULOU-KOKKA

4: 128-133 (1986)

PHARMAKON-Press: Epitheorese Klin. Farmakol. Farmakokinet.

4: 128-133 (1986)

In the rabbit serum, there is a substance that gives positive the reaction RIA for digitoxin. The continuous administration of amiodarone is unable to increase the level of the above substance. That only arrives, when an administration of digitoxin proceeds and only after eight days of a continuous amiodaro­ne administration. Digitoxin displacement by amiodaron from its binding sites is the possible reason. Amiodarone is also unable to influence the level of another factor that gives positive the RIA for digoxin. An increase of digoxin level appears only when there is a previous admini­stration of digitoxin. It is suggested, that digi­toxin which is displaced by amiodarone from its binding sites gives a RIA cross-reaction

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