Τόμος 7 (1989) – Τεύχος 2 – Άρθρο 2 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 7 (1989) – Issue 2 – Article 2 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

ΡΑΝΑΥΟΤΑ GALANOPOULOU AND P. GIANNAKOPOULOS

7: 73-85 (1989)

PHARMAKON-Press: Epitheorese Klin. Farmakol. Farmakokinet.

7: 73-85 (1989)

The understanding of all physiological mechanisms involved in gastric acid secretion is being held as a subject of study since the earliest of the present century. Current concepts are viewing the parietal cell as the target of all regulators of gastric acid secretion (histamin, Ach, gastrin and prosta­glandins) and assume distinct sites of action at the receptor level for each one of them. The theory that each gastric secretagogue can reinforce the action of other secretagogues by acting on its own receptor site; and that a certain blocker can minimise the response to other secretagogues is in addition to the developement of Η-2 receptor antagonists, a crucial step for pharmaceutical handling of peptic ulcer disease. H-2 antagonists are nowadays the cornerstone of nom surgical treatment of peptic ulcer disease. Thus, since the establishment of cimetidine, there has been a laboratory production of newer substances that are either used in clinical practice or held under experimental  or clinical trials. These mechanisms of gastric acid secretion, the newer H-2 receptor antagonists, their phar­macodynamic and pharmacokinetic properties and comparative studies to the classical H-2 receptor antagonists are further discussed below.

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