Τόμος 10 (1992) – Τεύχος 1 – Άρθρο 2 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 10 (1992) – Issue 1 – Article 2 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

10: 30-42 (1992)

PHARMAKON-Press: Epitheorese Klin. Farmakol. Farmakokinet.

10: 30-42 (1992)

Renal failure, antiarrhythmic drugs

Renal failure is commonly thought to have its role effect on the renal elimination of drugs. As will become apparent, renal failure has a variety of influences on drug kinetics, such as reducing nonrenal (pre­sumably hepatic) drug elimination, protein bin­ding, and the volume distribution of some drugs. The reasons for such changes are not always readily discernible, but nonetheless such changes must be taken into account if the antiarrhythmic drugs are to be used safety in patients with renal failure. In order to provi­de practical guidelines for prescribing antiar­rhythmic drug regimens in patients with renal failure, the literature has been reviewed and summarized.

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