Τόμος 27 (2009) – Τεύχος 1 – Άρθρο 13 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση – Volume 27 (2009) – Issue 1– Article 13 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition

Τίτλος – Title

Στατίνες και Oστική Αναγέννηση: Εφαρμογές στην Οδοντιατρική

Statins and bone regeneration: application in dental practice

Συγγραφέας – Author

Θεοδώρα Καρανικόλα1, Στέργιος Τσαρτσάλης2, Αναστάσιος Τσίρλης1, Μαρία Μυρωνίδου-Τζουβελέκη2

1Εργαστήριο Οδοντοφατνιακής Χειρουργικής, Χειρουργικής Εμφυτευματολογίας και Ακτινολογίας, Οδοντιατρική Σχολή, 2Α’ Εργαστήριο Φαρμακολογίας, Ιατρική Σχολή, Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης, Θεσσαλονίκη, Ελλάς

Theodora Karanikola1, Stergios Tsartsalis2, Anastasios Tsirlis1, Maria Mironidou-Tzouveleki2

1Department of Dentoalveolar/Implant Surgery and Radiology, Dental School and 2Α’ Laboratory of Pharmacology, Medical School, of the Aristotle University of Thessaloniki, Hellas

Παραπομπή – Citation
Καρανικόλα,Θ., Τσαρτσάλης,Σ., Τσίρλης,Α., Μυρωνίδου-Τζουβελέκη,Μ. :Στατίνες και Oστική Αναγέννηση: Εφαρμογές στην Οδοντιατρική,  Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 27: 43-46 (2009)

Karanikola,Th., Tsartsalis,S., Tsirlis,A., Mironidou-Tzouveleki,M. : Statins and bone regeneration: application in dental practice, Epitheorese Klin. Farmakol. Farmakokinet. 27: 43-46 (2009)
Ημερομηνία Δημοσιευσης – Publication Date
8 Μαρτίου 2009 – 2009-03-08
Γλώσσα Πλήρους Κειμένου –
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Ελληνικά – Greek

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Λέξεις κλειδιά – Keywords
Στατίνες, οστική αναγέννηση, οστικά ελλείμματα, οδοντιατρικές εφαρμογές
Statins, bone regeneration, bone defects, dental applications
Λοιποί Όροι – Other Terms

Άρθρο Ανασκόπησης

Review Article

Περίληψη – Summary

Statins are the most common antihyperlypidemic drugs consumed by millions of patients worldwide. Recent research has shed light on their implication in bone regeneration. Statins may regulate this process mainly by inducing the expression of an osteoblast differentiation-promoting factor, Bone Morphogenetic Protein-2 (BMP-2). Given that bone defects consist a major problem for modern Periodontology and Implantology, the use of statins seems a promising approach, especially because currently used methods for the restoration of these defects are not overall sufficient. On the other hand, it is clear that topical statin administration favours bone formation and promotes osteogenesis around titanium implants. Further research is needed in order to establish the effectiveness of statins as well as to examine other ways of administration apart from topical injection, for this purpose.

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