|
Τίτλος – Title
|
Μεταβολές Επιπέδων Κινολονών στον Ορρό και στο Σίαλο Υγιών Εθελοντών υπό την Επίδραση Ακεταζολαμίδης Changes of Quinolone Levels in Serum and Saliva of Normal Volunteers under the Administration Acetazolamide |
|
|
Συγγραφέας – Author
|
Χ. Καραγεωργίου, Μ. Καλαντζή, Ι. Κωσταρά, Μ. Κατραμάδου, Χρ. Τεσσερομμάτη Εργαστήριο Φαρμακολογίας, Ιατρική Σχολή Αθηνών, Πανεπιστήμιο Αθηνών, Αθήνα, Ελλάς H. Carageorgiou ,M. Kalatzi, I. Kostara, M. Katramadou, C. Tesseromatis Department of Pharmacology, Medical School, Athens University, Greece |
|
|
Παραπομπή – Citation
|
Καραγεωργίου,Χ., Καλαντζή,Μ., Κωσταρά,Ι., Κατραμάδου,Μ., Τεσσερομμάτη,Χ. : Μεταβολές Επιπέδων Κινολονών στον Ορρό και στο Σίαλο Υγιών Εθελοντών υπό την Επίδραση Ακεταζολαμίδης, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 27: 40-42 (2009)
Carageorgiou,H., Kalatzi,M., Kostara,I., Katramadou,M., Tesseromatis,C. : Changes of Quinolone Levels in Serum and Saliva of Normal Volunteers under the Administration Acetazolamide, Epitheorese Klin. Farmakol. Farmakokinet. 27: 40-42 (2009)
|
|
|
Ημερομηνία Δημοσιευσης – Publication Date
|
8 Μαρτίου 2009 – 2009-03-08
|
|
|
Γλώσσα Πλήρους Κειμένου –
Full Text Language |
Ελληνικά – Greek |
|
|
Παραγγελία – Αγορά –
Order – Buy |
Ηλεκτρονική Μορφή: pdf (15 €) –
Digital Type: pdf (15 €) pharmakonpress[at]pharmakonpress[.]gr |
|
|
Λέξεις κλειδιά – Keywords
|
–
Quinolones, acetazolamide, human serum, saliva
|
|
|
Λοιποί Όροι – Other Terms
|
Κλινική Μελέτη Clinical Trial |
|
|
Περίληψη – Summary
|
– Quinolones are one of the main antimicrobial groups used for the treatment of different infections. The success of their therapeutic outcome depends οn the wide antimicrobial spectrum, lipophilicity, pKa and penetration in tissues and biological fluids. The aim of the present study was to evaluate and compare the distribution of four quinolones (Norfloxacin, Ofloxacin, Ciprofloxacin, Pefloxacin) in samples of serum and saliva (both mixed and parotid) of 6 normal volunteers, with and without the co-administration of acetazolamide (carbonic anhydrase inhibitor). Drug administration took place in two phases: a) a single dose of each quinolone was administered p.o. between 6.30-8.30 am and b) acetazolamide was administered in 3 doses/6hrs and the last dose was given simultaneously with quinolones, as stated above. Blood and saliva samples were taken at 2 and 5 hours post-drug administration. Mixed saliva samples were obtained from the bottom of the oral cavity while parotid saliva collection was performed by means of the Lasley instrument. Quinolone levels in serum and saliva were measured by biological agar diffusion method with holes. Fluoroquinolones were detected in both saliva and serum with their concentrations peaking in serum and following the order: serum >parotid saliva >mixed saliva. Quinolone concentrations in saliva were proportional to those in serum, with their relevant concentrations following the pattern: Pefloxacin >Ofloxacin>Norfloxacin>Ciprofloxacin.Acetazolamide co-administration resulted in reduction of pefloxacin levels in serum, reduction of pefloxacin levels in parotid saliva and elevation of ciprofloxacin levels in both mixed and parotid saliva. Paired t-test was used for the statistical analysis. |
|
|
Αναφορές – References
|
1. Κatzung G. Bertram (Ed.): Basic and Clinical Pharmacology. 9th ed.. Mc Graw Hill Intern ed., 2004
2. Müller M., Stass H., Brunner M., Möller J.G., Lackner E., Eichler H.G.: Penetration of moxifloxacin into peripheral compartments in humans. Antimicrob. Agents Chemother. 43: 2345-2349 (1999) 3. Li Q., Naora K., Hirano H., Okunishi H., Iwamoto K.: Comparative study on salivary distribution of fluoroquinolones in rats. Biol. Pharm. Bull. 25: 1084-1089 (2002) 4. Beal A.M.: The effect of carbonic anhydrase inhibitors on secretion by the parotid and mandibular glands of red kangaroos Macropus rufus. J. Comp. Physiol. [B]. 161: 611-619 (1991) 5. Sagström S., McMillan E.B., Marijianowski M., Mulders H., Roomans G.M.: Changes in rat and mouse salivary glands and pancreas after chronic treatment with diuretics: a potential animal model for cystic fibrosis. Scanning Microsc. 4: 161-170 (1990) discussion 6. Mullangi R., Agrawal S., Srinivas N.R.: Measurement of xenobiotics in saliva: is saliva an attractive alternative matrix? Case studies and analytical perspectives. Biomed. Chromatogr. 23: 3-25 (2009) 7. Abdollahi M., Isazadeh Z.: Inhibition of rat parotid and submandibular gland functions by ofloxacin, a fluoroquoino-lone antibiotic. Fundam. Clin. Pharmacol. 15: 307-311 (2001) 8. Wood J.H., Flora K.P., Narasimhachari N., Baker C.A.: Dependence of salivary drug concentration on salivary flow rate. Methods Find. Exp. Clin. Pharmacol. 4: 255-260 (1982) 9. Ono K., Morimoto Y., Inoue H., Masuda W., Tanaka T., Inenaga K.: Relationship of the unstimulated whole saliva flow rate and salivary gland size estimated by magnetic resonance image in healthy young humans. Arch. Oral Biol. 51: 345-349 (2006) 10. Sörgel F., Jaehde U., Naber K., Stephan U.: Pharmacokinetic disposition of quinolones in human body fluids and tissues. Clin. Pharmacokinet. 16(Suppl 1): 5-24 (1989) |
|
Online ISSN 1011-6575
• Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE
SCImago Journal and Country Rank Factor
Articles published in this Journal are Indexed or Abstracted in:
• Chemical Abstracts
• Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE
SCImago Journal and Country Rank Factor
Τι είναι η Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση-Οδηγίες προς τους Συγγραφείς
What is Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition-Instrunctions to Authors
Άρθρα Δημοσιευμένα στην Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση
Articles Published in Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition
Συντακτικη Επιτροπή-Editorial Board
|
ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ – ANNUAL SUBSCRIPTION
|
||
|
Γλώσσα Πλήρους Κειμένου –
Full Text Language |
Ελληνικά – Greek
|
|
|
Παραγγελία – Αγορά –
Order – Buy |
pharmakonpress[at]pharmakonpress[.]gr
|
|
|
pharmakonpress[at]pharmakonpress[.]gr
|
||