Τίτλος – Title
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Οστεονέκρωση των Γνάθων από Διφωσφονικά Bisphosphonates Related Osteonecrosis of the Jaws |
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Συγγραφέας – Author
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Ι. Μελακόπουλος, Χ. Τεσσερομμάτη Eργαστήριο Φαρμακολογίας Ιατρικής Σχολής, Πανεπιστημίου Αθηνών Μικράς Ασίας 75, Αθήνα 11527, Ελλάς I. Melakopoulos, C. Tesseromatis Laboratory of Experimental Pharmacology, Medical School, University of Athens, M. Asias 75, Athens 11527, Hellas |
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Παραπομπή – Citation
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Μελακόπουλος,Ι., Τεσσερομμάτη,Χ. : Οστεονέκρωση των Γνάθων από Διφωσφονικά, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 27: 58-60 (2009)
Melakopoulos,I., Tesseromatis,C. : Bisphosphonates Related Osteonecrosis of the Jaws, Epitheorese Klin. Farmakol. Farmakokinet. 27: 58-60 (2009)
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Ημερομηνία Δημοσιευσης – Publication Date
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8 Μαρτίου 2009 – 2009-03-08
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Γλώσσα Πλήρους Κειμένου –
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Ελληνικά – Greek |
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Λέξεις κλειδιά – Keywords
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Bisphophonates, osteonecrosis, jaws
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Λοιποί Όροι – Other Terms
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Άρθρο Article |
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Περίληψη – Summary
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– Bisphosphonates are well established drugs for the treatment of excessive bone resorption in myeloma, bone metastases and osteoporosis. Bisphosphonates related osteonecrosis of the jaws (BRONJ) is a new situation presented after 2003 due to bisphosphonates. Zolendronate who has a high potency as well a prolonged duration of action seems to be responsible for more than a half of BRONJ cases. Patients scheduled for i.v. bisphosphonates therapy have to be evaluated and dental treated prior to therapy to prevent BRONJ and necrosis when presented should be treated conservatively. BRONJ is rare when oral bisphosphonates are used. |
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Αναφορές – References
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1. Fleisch H.: Bisphosphonates: mechanisms of action. Endocr. Rev. 19: 80-100 (1998)
2. Russell G., Xia Z., Dunford J., Opperman U., et al.: Bisphosphonates an update on mechanisms of action and how these relate to clinical efficacy. Ann. N.Y. Acad. Sci. : 209-257 (2007) 3. Rogers M., Gordon S., Benford H et al.: Cellular and molecular mechanisms of action of bisphosphonates. Cancer Supp. 88(12 Suppl): 2961-2978 (2000) 4. Wang J., Goodger N.M., Pogrel M.A.: Osteonecrosis of the jaws associated with cancer chemotherapy. J. Oral Maxillofac. Surg. 61: 1104-1107 (2003) 5. Marx R.: Pamidronate and zoledronate induced avascular necrosis of the jaws: a growing epidemic (Letter to the editor). J. Oral Maxillofac. Surg. 61: 1115-1117 (2003) 6. Migliorati C.: Bisphosphonates and oral cavity avascular bone necrosis. J. Clin. Oncol. 21: 4253-4254 (2003) 7. Μελακόπουλος Ι., Πατρικίου Α.: Οστεονέκρωση της κάτω γνάθου από χρήση διφωσφονικών. Περιγραφή περίπτωσης. Στοματολογία 62: 31-34 (2005) 8. Ruggierο S., Mehrotra B., Rosenberg T., Engroff S.: Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases. J. Oral Maxillofac. Surg. 62: 527-534 (2004) 9. Marx R., Cillo J., Ulloa J.: Oral bisphosphonate-Induced osteonecrosis: Risk factors, prediction of risk using serum CTX testing, prevention, and treatment. J. Oral Maxillofac. Surg. 65: 2397-2410 (2007) 10. Bamias A., Kastritis E., Bamia C., Moulopoulos .LA., Melakopoulos I., Bozas G., et al.: Osteonecrosis of the jaw in cancer after treatment with bisphosphonates: incidence and risk factors. J. Clin. Oncol. 23: 8580-8587 (2005) 11. Advisory Task Force on Bisphosphonate-Related Ostenonecrosis of the Jaws, American Association of Oral and Maxillofacial Surgeons. American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws. J. Oral Maxillofac. Surg. 65: 369-376 (2007) 12. Marx R.E., Sawatari Y., Fortin M., Broumand V.: Bisphosphonate-induced exposed bone (osteonecrosis/osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment. J. Oral Maxillofac. Surg. 63: 1567-1575 (2005) 13. Migliorati C.A., Schubert M.M., Peterson D.E., Seneda L.M.: Bisphosphonate associated osteonecrosis of mandibular and maxillary bone: an emerging oral complication of supportive cancer therapy. Cancer 104: 83-93 (2005) 14. Dimopoulos M.A., Kastritis E., Anagnostopoulos A., Melakopoulos I., et al.: Osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates: evidence of increased risk after treatment with zoledronic acid. Haemaologica 91: 968-971 (2006) 15. Dimopoulos M.A., Kastritis E., Bamia C., Melakopoulos I., Gika D., Roussou M., Migkou M., Eleftherakis-Papaiakovou E., Christoulas D., Terpos E., Bamias A.: Reduction of osteonecrosis of the jaw (ONJ) after implementation of preventive measures in patients with multiple myeloma treated with zoledronic acid. Ann. Oncol. 20: 117-120 (2009) |
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